What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Drizalma Sprinkle (Duloxetine)


Drizalma Sprinkle (Duloxetine)

Prescription Required


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  • Product Details


    Drizalma Sprinkle (duloxetine delayed-release) is classified as a serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depressive disorder (MDD) in adults, generalized anxiety disorder (GAD) in adults and pediatric patients between 7 years old and 17 years old, diabetic peripheral neuropathic pain (DPNP) in adults, and chronic musculoskeletal pain in adults.

    Fact Table




    US FDA, US DailyMed, EU EMA


    32% to 80%

    Legal status


    Chemical Name


    Elimination half-life

    12 hours

    Dosage (Strength)

    20mg, 30mg, 40mg, 60mg


    Consult Doctor


    Drizalma Sprinkle

    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth (tablets)


    Drizalma Sprinkle is available in 20 mg, 30 mg, 40 mg, and 60 mg delayed-release capsules. The capsules can be taken with or without food. Do not crush or chew the capsule. You may swallow the capsule whole or open it to sprinkle over applesauce or administered by nasogastric tube.

    If you miss a dose, take it as soon as you remember. Do not take two doses at the same time.

    Drizalma Sprinkle Dosing


    Starting Dose

    Target Dose

    Maximum Dose

    40 mg/day to 60 mg/day

    Acute treatment: 40 mg/day (20 mg twice daily) to 60 mg/day (60 mg once daily or 30 mg twice daily)

    Maintenance treatment: 60 mg/day

    120 mg/day


    Starting Dose

    Target Dose

    Maximum Dose


    60 mg/day

    60 mg once daily

    120 mg/day


    30 mg/day

    60 mg once daily

    120 mg/day

    Children and Adolescents (7 to 17 years of age)

    30 mg/day

    30 mg to 60 mg once daily

    120 mg/day


    Starting Dose

    Target Dose

    Maximum Dose

    60 mg/day

    60 mg once daily

    60 mg/day

    Chronic Musculoskeletal Pain

    Starting Dose

    Target Dose

    Maximum Dose

    30 mg/day

    60 mg once daily

    60 mg/day


    Duloxetine hydrochloride is the active ingredient contained in Drizalma Sprinkle capsules.


    Do not take monoamine oxidase inhibitors (MAOIs) for treating psychiatric disorders with Drizalma Sprinkle or within 5 days of stopping Drizalma Sprinkle. 

    Do not take Drizalma Sprinkle within 2 weeks of stopping an MAOI for the treatment of psychiatric disorders. 

    Do not start taking Drizalma Sprinkle if you are taking linezolid or intravenous methylene blue.



    See full prescribing information for complete boxed warning.

    • Increased risk of suicidal thinking and behavior in pediatric and young adult patients taking antidepressants 
    • Closely monitor all antidepressant-treated patients for clinical worsening and emergence of suicidal thoughts and behaviors 
    • Talk to your doctor about your allergies.
    • Tell your doctor about all the medications you take, including prescription, over-the-counter, vitamins, and supplements.
    • Tell your doctor if you have liver problems. Drizalma Sprinkle may cause liver failure or death. Tell your doctor right away if you develop yellowing of your eyes or skin or any other symptoms.
    • Tell your doctor if you drink alcohol or have chronic liver disease.
    • Tell your doctor if you have blood pressure problems. Drizalma Sprinkle may cause your blood pressure to suddenly drop upon standing from sitting or lying down.
    • Your risk for serotonin syndrome is increased if you take Drizalma Sprinkle by itself or with other serotonergic medications (SSRI, SNRI, triptans). Stop taking Drizalma Sprinkle and seek medical care right away if you experience agitation, restlessness, trouble sleeping, confusion, fast heart rate, blood pressure problems, dilated pupils, muscle twitches, muscle rigidity, sweating, diarrhea, headache, or shivering. 
    • Drizalma Sprinkle may increase your risk for bleeding, especially if you are taking NSAIDs, aspirin, warfarin, or other antiplatelets or anticoagulants. Tell your doctor right away if you notice signs of bleeding, including bleeding from your gums, bleeding from your nose, or blood in your stool.
    • Drizalma Sprinkle can cause severe skin reactions. Stop taking Drizalma Sprinkle if you develop blisters, peeling rash, or mucosal erosions.
    • Do not stop taking Drizalma Sprinkle suddenly due to the risk of discontinuation syndrome. You should gradually be tapered off.
    • Caution should be used if you have bipolar disorder.
    • Tell your doctor if you have eye problems such as glaucoma.
    • Tell your doctor if you have seizures.
    • Tell your doctor if you have blood pressure problems.
    • Drizalma Sprinkle can cause low sodium levels. Tell your doctor right away if you experience nausea, vomiting, headache, confusion, drowsiness, weakness, tiredness, muscle weakness, muscle spasms or cramps, restlessness, irritability, or seizures. 
    • Tell your doctor if you have diabetes.

    Side Effects

    Tell your doctor if you develop side effects that are bothersome or won't go away. The most common side effects of Drizalma Sprinkle include dry mouth, nausea, drowsiness, constipation, decreased appetite, and excessive sweating. 


    1. Drizalma Sprinkle Prescribing Information. Cranbury, NJ: Sun Pharmaceutical Industries, Inc.; 2019.
    2. Serotonin syndrome. Mayo Clinic. January 22, 2022. Accessed January 27, 2022.
    3. Hyponatremia. Mayo Clinic. May 23, 2020. Accessed January 27, 2022.

    Frequently Asked Questions about Drizalma Sprinkle

    What is Drizalma Sprinkle used for?

    Drizalma Sprinkle treats two main conditions: major depressive disorder and chronic pain from nerve damage (neuropathic pain) or fibromyalgia.

    How does it work?

    Drizalma Sprinkle affects brain chemicals called serotonin and norepinephrine, which help regulate mood and pain signals.

    What is the dosage?

    Dosage varies depending on the condition treated. It usually starts at 30mg once daily and may be adjusted by your doctor.

    How long does it take to work?

    It can take 2-4 weeks to see full benefits for depression and 2 weeks for pain relief.

    What are common side effects?

    Nausea, dizziness, fatigue, dry mouth, and headache are common but usually temporary. Tell your doctor if they become bothersome.

    Can I take Drizalma Sprinkle with other medications?

    Some medications can interact with Drizalma Sprinkle, so tell your doctor about all your medications and supplements.

    Can I drink alcohol while taking Drizalma Sprinkle?

    It's best to avoid alcohol as it can increase the risk of side effects like drowsiness and dizziness.

    Can I breastfeed while taking Drizalma Sprinkle?

    Talk to your doctor about the risks and benefits before breastfeeding while taking this medication.

    What should I do if I miss a dose?

    Take it as soon as you remember, but skip the missed dose if it's near time for your next one. Never take a double dose.

    Is there anything else I should know?

    Drizalma Sprinkle can increase the risk of falls, especially in older adults. Be cautious when getting up from sitting or lying down.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13575

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