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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details


    Duavee contains conjugated estrogens and an estrogen agonist/antagonist, bazedoxifene. The medication is used in women with a uterus to treat menopausal symptoms and to prevent postmenopausal osteroporosis, or loss of bone mass that results in weak bones.

    Duavee is available in an oral tablet containing 0.45 mg of conjugated estrogens and 20 mg of bazedoxifene.

    Fact Table


    C30H34N2O3 · C2H4O2


    US DailyMed



    Legal status


    Chemical Name

    Bazedoxifene/conjugated estrogens

    Elimination half-life

    17 hours

    Dosage (Strength)

    0.45mg/20 mg


    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By Mouth


    Duavee should be taken as your doctor has prescribed. If you have any questions or concerns, talk to your doctor or pharmacist.

    Duavee is recommended to be taken by mouth once a day, at the same time each day. The tablet should be swallowed whole. You may take it with or without food.


    Each Duavee tablet contains conjugated estrogens and bazedoxifene. 

    Inactive ingredients include calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, ascorbic acid, sucrose palmitic acid ester, hydroxyethylcellulose, titanium dioxide, red iron oxide, yellow iron oxide, black iron oxide, povidone, polydextrose, maltitol, poloxamer 188, propylene glycol, and isopropyl alcohol.


    You should not take Duavee if you have any of the following conditions:

    • Abnormal vaginal bleeding that's undiagnosed 
    • Current, suspected, or a history of breast cancer 
    • Current or suspected estrogen-dependent neoplasia 
    • Current or a history of blood clots in the veins
    • Current or a history of blood clots in the arteries
    • Allergy to estrogens, bazedoxifene, or any of its other ingredients
    • Liver problems 
    • Protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders 
    • Currently pregnant or suspect pregnancy


    Duavee contains FDA Boxed Warnings regarding the following:

    • Additional estrogens should be avoided in women who are taking Duavee 
    • Women who have a uterus and take unopposed estrogens are at an increased risk of endometrial cancer 
    • Estrogens should not be used to prevent cardiovascular disease or dementia 
    • The Women's Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) 
    • The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women who were at least 65 years old
    • Before you start treatment with Duavee, talk to your doctor about the following:
      • All the prescription and nonprescription medications you take
      • Your allergies
      • Your medical history and current health conditions
      • Your pregnancy or breastfeeding status
    • Do not take progestins or extra estrogens or estrogen-agonists/antagonists while you are taking Duavee. Duavee contains estrogens, which can increase the risk of certain conditions.
    • Duavee can increase the risk of serious cardiovascular problems, including stroke and blood clots in the legs, lungs, or retinal vessels of the eye.
    • Estrogens can increase the risk of endometrial cancer, breast cancer, and ovarian cancer. The effect of Duavee on the risk of breast and ovarian cancers is not known. Women should receive recommended examinations and checkups.
    • Estrogens can increase the risk of gallbladder problems.
    • Estrogens can cause a blood clot in the retinal vessels of the eye. Seek emergency care right away if you experience vision problems such as loss of vision, bulging of the eyes, double vision, or migraine. Your doctor may decide to stop Duavee depending on the results of your eye examination.
    • Estrogens may cause high blood pressure.
    • Estrogens may increase triglyceride levels that can lead to pancreatitis.
    • Estrogens may worsen liver problems in women with impaired liver function or a history of cholestatic jaundice. Duavee should not be used in women with liver problems.
    • Estrogens may worsen hypothyroidism. Women who are taking thyroid hormone replacement may need a dose increase in their thyroid hormone replacement while they are taking Duavee. 
    • Estrogens may cause fluid retention. Caution should be used in women with heart problems. Duavee is not recommended in women with kidney problems.
    • Estrogens may worsen symptoms of angioedema (swelling beneath the skin) in women who have hereditary angioedema.
    • Estrogens may worsen asthma, diabetes, seizures, migraine, porphyria, lupus, or benign liver tumors. Caution should be used in women with any of these conditions.
    • Duavee should not be used in premenopausal women.

    Side Effects

    Like all drugs, Duavee has the potential to cause side effects. Duavee side effects include muscle spasms, nausea, diarrhea, indigestion, stomach pain, pain in the mouth, pain in the neck, and dizziness. These may not be all the side effects that can occur, however.

    Tell your doctor right away if you have side effects that are bothersome or persistent.


    1. Duavee (conjugated estrogens/bazedoxifene). Philadelphia, PA: Wyeth Pharmaceuticals LLC; 2022.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13222

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