Description
Duavee (Conjugated Estrogens / Bazedoxifene) is a prescription medication used in postmenopausal women who still have a uterus.
Conjugated estrogens replace declining estrogen levels after menopause, therefore relieving menopausal symptoms like hot flashes and supporting bone health (preventing postmenopausal osteoporosis).
Meanwhile, bazedoxifene is a selective estrogen agonist/antagonist that blocks estrogen’s effects in the uterus, to prevent its potential adverse side effects, such as an unwanted thickening of the uterine lining (endometrial hyperplasia).
This helps reduce the need for a progestin in female postmenopausal women with a uterus.
| Fact Table |
| Formula |
Conjugated estrogens: mixture; Bazedoxifene: C30H34N2O3; Bazedoxifene acetate: C32H38N2O5 |
| License |
US FDA, EMA, Health Canada, TGA |
| Bioavailability |
Conjugated estrogens: well absorbed; Bazedoxifene: approximately 6% |
| Legal status |
Rx-only |
| Chemical Name |
Conjugated estrogens: mixture of sodium salts of water-soluble estrogen sulfates; Bazedoxifene acetate: 1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, monoacetate |
| Elimination half-life |
Total estrone: approximately 17 hours; Bazedoxifene: approximately 30 hours |
| Dosage (Strength) |
Conjugated estrogens 0.45 mg/bazedoxifene 20 mg tablet once daily; 20 mg bazedoxifene is equivalent to 22.6 mg bazedoxifene acetate |
| Pregnancy |
Contraindicated in pregnancy; may cause fetal harm |
| Brands |
Duavee, Duavive |
| Protein binding |
Conjugated estrogens: bound to SHBG and albumin; Bazedoxifene: 98%–99% |
| PubChem CID |
Duavee: 85364158; Conjugated estrogens: 656613; Bazedoxifene: 154257 |
| MedlinePlus |
a614004 |
| ChEBI |
Conjugated estrogens: 8389; Bazedoxifene: 135947 |
| ATC code |
G03CC07 |
| DrugBank |
Conjugated estrogens: DB00286; Bazedoxifene: DB06401 |
| KEGG |
D10579; Conjugated estrogens: D04070; Bazedoxifene acetate: D03062 |
| Routes of administration |
Oral |
Directions
You can buy Duavee medication at a low cost here at Canada Pharmacy. All you need is a valid prescription from your healthcare provider. Duavee is available as film-coated tablets, each containing 0.45 mg of conjugated estrogens and 20 mg of bazedoxifene.
You should take this medication exactly as advised by your healthcare provider, and for the shortest time needed. Your doctor will assess your symptoms, risk, and other factors to determine how long you should take Duavee.
Your provider will typically prescribe one tablet daily that should be taken on approximately the same time each day. Swallow whole, with water, with or without food.
Ingredients
The active ingredients in Duavee are 0.45 mg of conjugated estrogens and 20 mg of bazedoxifene.
Cautions
Before starting Duavee medication, be sure you report any existing health conditions, medications you use, allergies, and whether you are pregnant or breastfeeding to your healthcare provider. This helps them determine whether the medication is suitable for you and enables them to monitor you adequately during treatment.
For example, they may routinely check your blood pressure, breast and uterine health, lipids like cholesterol and triglycerides, and thyroid hormone levels. While taking Duavee, ensure you report any new or concerning symptoms.
Duavee medication may cause, worsen, or increase your risk of the following:
- Gallbladder disease (e.g. gallstones)
- Increased triglyceride levels (especially in patients with a history of high triglycerides)
- Reduced blood calcium levels (especially in women with hypoparathyroidism)
- Fluid retention (may worsen heart or kidney disorders and other conditions)
- Vision changes (e.g. retinal vein thrombosis)
- Stroke
- Deep vein thrombosis
- Pulmonary embolism
- Probable dementia (in women 65 and older)
- Hereditary angioedema
Immediately report any signs of the above conditions to your healthcare provider.
Notify your doctor if you notice any unusual vaginal bleeding, since this may signal serious conditions, such as endometrial cancer or other uterine problems.
Your doctor may monitor you for symptoms of ovarian cancer, since some estrogen therapies have been associated with this condition. However, the exact risk with Duavee is unknown.
If you take thyroid hormone replacement, you may need a dose adjustment while on Duavee, since estrogens may increase the levels of thyroid-binding proteins.
You should not take Duavee with additional estrogens, progestins, or other estrogen agonist/antagonists, unless specifically prescribed by your healthcare provider.
Contraindications
There are some medical conditions or situations that make Duavee unsuitable for you. These include the following:
- Undiagnosed abnormal uterine bleeding.
- Known, suspected, or a history of breast cancer.
- Estrogen-dependent cancers, e.g. uterine cancer.
- Active or past deep vein thrombosis or pulmonary embolism.
- Current or a history of arterial thromboembolic disease, e.g. stroke or heart attack.
- Active liver disease or dysfunction.
- Blood-clotting disorders, including protein C, protein S, or antithrombin deficiency.
- Pregnancy (Duavee can cause fetal harm).
- Allergies to any active or inactive ingredient in Duavee.
Side Effects
Some of the most frequently observed and clinically relevant side effects include muscle spasms, nausea, diarrhea, indigestion, upper abdominal pain, and dizziness.
Serious side effects needing urgent medical attention include blood clots, stroke, heart attack, abnormal vaginal bleeding that may indicate endometrial cancer, breast or ovarian cancer (reported with some estrogen therapies), gallbladder disease, liver problems, jaundice, vision loss or changes.
Rare, but severe side effects include severe allergic reactions, and very high triglycerides that may result in pancreatitis.
This is not a complete list of Duavee side effects. Consult your healthcare provider if you notice any persistent or concerning side effects of Duavee medication.
Buy Duavee medication here at Canada Pharmacy at a low cost!
References
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About DUAVEE® (conjugated estrogens/bazedoxifene) | Safety Info.
Safety Info
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IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 15351
Prescription Required
