What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Durolane (Sodium Hyaluronate)


Durolane (Sodium Hyaluronate)

Prescription Required

60mg 3ml

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  • Product Details


    Durolane is an injectable medication used to relieve pain due to osteoarthritis of the knee in patients who did not experience improvement with non-pharmacological therapies or simple pain relievers such as acetaminophen.

    Durolane injection contains sodium hyaluronate that helps lubricate and cushion the knee joints, providing pain relief.

    Fact Table




    US FDA



    Legal status


    Chemical Name

    Sodium Hyaluronate

    Elimination half-life

    17 hours to 1.5 days

    Dosage (Strength)

    24 mg/3ml 6 ml 2x3ml


    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration



    Talk to your doctor about any questions or concerns you have about Durolane injection. Discuss your treatment schedule with your doctor.

    Durolane 60 mg/3 mL is available in 3 mL pre-filled syringes. Each mL contains 20 mg of stabilized sodium hyaluronate. One syringe of Durolane is injected into the knee joint. 


    Each pre-filled syringe contains 20 mg of stabilized sodium hyaluronate per mL. Other ingredients include sodium chloride, potassium dihydrogen phosphate, disodium hydrogen phosphate dihydrate, and water for injection.


    Durolane injections should not be used if you have infections in the knee joint or infections or diseases of the skin where Durolane is injected.

    Durolane injections should not be used if you are allergic to sodium hyaluronate or any of the other ingredients contained in the medication.


    • Before starting treatment for your knee osteoarthritis with Durolane, be sure to discuss the following with your doctor:
      • Your allergies
      • All the medications take 
      • Your health problems 
      • If you are pregnant or breastfeeding
    • Strict aseptic administration technique is recommended when using Durolane.
    • Each Durolane injection is for single use only and must be used once the package is opened. Durolane injections should not be re-used. The syringes and any unused Durolane should be disposed of.
    • Avoid using Durolane if the syringe blister package is opened or damaged.
    • Avoid using skin disinfectants that contain quaternary ammonium salts.
    • Durolane should not be injected into blood vessels, outside of the joint, or into the synovial tissue or capsule. 
    • Caution with Durolane should be used if you have pre-existing chondrocalcinosis as the injection could cause an attack.
    • You should not participate in strenuous or prolonged weight-bearing activities within 48 hours of receiving a Durolane injection.
    • You may experience pain or swelling of the affected knee joint after receiving a Durolane injection.
    • Durolane should be stored at temperatures between 32°F-86° F (0°C-30° C).

    Side Effects

    If you develop side effects that bother you or won't resolve, contact your doctor immediately. Durolane is associated with side effects that include pain at the injection site and swelling and pain at the joint. 


    Durolane Instructions for Use. Durham, NC: Bioventus LLC.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 9306

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