What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Emend (Aprepitant)
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Product Details
Description
EMEND (aprepitant) is a medication prescribed to treat chemotherapy-induced nausea and vomiting (CINV). EMEND should only be used under the close supervision of a doctor that treats cancer (oncologist).
EMEND is approved to treat CINV in patients who are being treated with moderate or highly emetogenic chemotherapy. It can also be used to prevent postoperative nausea and vomiting (PONV).
EMEND works by blocking NK1 receptors. NK1 receptors are involved in causing nausea and vomiting, so blocking these receptors helps to prevent this response.
Directions
Take EMEND exactly as prescribed by the oncologist. EMEND capsules should only be used by adults and pediatric patients that are 12 years or older.
The normal dose is 125 mg by mouth one hour before chemotherapy on day 1, and 80 mg by mouth one hour before chemotherapy on days 2 and 3.
EMEND can be taken with or without food.
Swallow EMEND capsules whole without opening or chewing.
Ingredients
The active ingredient in EMEND is aprepitant.
Interactions
EMEND has the potential to cause many different drug-drug interactions. Speak with your oncologist about all medications that you are taking.
- Benzodiazepines
- Carbamazepine
- Clarithromycin
- Dexamethasone
- Diltiazem
- Dolasetron
- Granisetron
- Hormonal contraceptives
- Itraconazole
- Ketoconazole
- Methylprednisolone
- Nefazodone
- Nelfinavir
- Ondansetron
- Phenytoin
- Pimozide
- Rifampin
- Ritonavir
- Troleandomycin
- Warfarin
Cautions
EMEND should not be used as a long-term medication to treat nausea and vomiting.
Side Effects
The list of EMEND side effects includes:
- Abdominal pain
- Asthenia
- Constipation
- Cough
- Decreased appetite
- Decreased white blood cells
- Dehydration
- Diarrhea
- Dizziness
- Dyspepsia
- Fatigue
- Headache
- Hiccups
- Hypotension
- Increased liver enzymes
- Neutropenia
Speak with your oncologist to review the full list of adverse reactions that may apply to your specific situation.References
- Emend [package insert]. Whitehouse Station, NC: Merck; 2015.
Fact Table
Formula
C23H21F7N4O3
License
AU, EU EMA, US FDA
Bioavailability
60-65%
Legal status
RX Only
Chemical Name
Aprepitant
Elimination half-life
9-13 hours
Dosage (Strength)
80mg (2 tablets), 1x125+2x80mg (3 capsules)
Pregnancy
Consult a doctor
Brands
Cinvanti, Emend
Protein binding
less than 95%
PubChem CID
6918365
MedlinePlus
a604003
ChEBI
499361
ATC code
A04AD12
DrugBank
DB00673
KEGG
D02968
Routes of administration
By mouth
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10098
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