A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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The recommended starting dose of Entresto is one tablet of 49 mg/51 mg twice daily, except in certain situations. The dose should be doubled at 2-4 weeks to the target dose of one tablet of 97 mg/103 mg twice daily, as tolerated by the patient. Entresto may be administered with or without food. The tablets must be swallowed with a glass of water.
Each film-coated tablet contains sacubitril and valsartan (as sacubitril valsartan sodium salt complex) as active ingredients.
Do not take ENTRESTO if you: 1)are allergic to sacubitril or valsartan or any of the ingredients in ENTRESTO 2)have had an allergic reaction including swelling of your face, lips, tongue, throat (angioedema) or trouble breathing while taking a type of medicine called an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) 3)take an ACE inhibitor medicine. Do not take ENTRESTO for at least 36 hours before or after you take an ACE inhibitor medicine. Talk with your doctor or pharmacist before taking ENTRESTO if you are not sure if you take an ACE inhibitor medicine have diabetes and take a medicine that contains aliskiren
ENTRESTO may cause serious side effects including:
angioedema that may cause trouble breathing and death. Get emergency medical help right away if you have symptoms of angioedema or trouble breathing. Do not take ENTRESTO again if you have had angioedema while taking ENTRESTO. People who are Black or who have had angioedema and take ENTRESTO may have a higher risk of having angioedema
low blood pressure (hypotension). Call your doctor if you become dizzy or lightheaded, or you develop extreme fatigue
increased amount of potassium in your blood
The most common side effects were low blood pressure, high potassium, cough, dizziness, and kidney problems.