What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Envarsus XR (Tacrolimus)


Envarsus XR (Tacrolimus)

Prescription Required


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  • Product Details


    ENVARSUS XR (tacrolimus) is a medication prescribed for people who have received kidney transplants. It prevents organ rejection by suppressing the immune system.

    When people receive kidney transplants, their body does not recognize the foreign organ and tries to attack it. ENVARSUS XR prevents the activation of T-cells, which are cells of the immune system that attack foreign bodies.

    ENVARSUS XR requires careful monitoring by the doctor to ensure correct blood levels.


    The prescribing doctor will determine the appropriate dose. Take it exactly as prescribed by the doctor and do not adjust the dose.


    The active ingredient in ENVARSUS XR is tacrolimus.


    ENVARSUS XR and other forms of tacrolimus have many drug-drug interactions. Some of these interactions can be toxic, and some can decrease the drug levels until it is ineffective, which can cause organ rejection. Never start, stop, or change the drugs you are taking without talking with your doctor and pharmacist first.

    • Alcohol
    • Amiodarone
    • Anticonvulsants
    • Azole antifungals
    • Boceprevir
    • Carbamazepine
    • Chloramphenicol
    • Cimetidine
    • Clarithromycin
    • Diltiazem
    • Ethinyl Estradiol
    • Danazol
    • Lansoprazole
    • Magnesium and aluminum antacids
    • Methylprednisolone
    • Metoclopramide
    • Mycophenolic acid
    • Nefazodone
    • Nelfinavir
    • Nicardipine
    • Nifedipine
    • Omeprazole
    • Phenobarbital
    • Prednisone
    • Rifabutin
    • Rifampin
    • Ritonavir
    • St. John's Wort
    • Telaprevir
    • Troleandomycin
    • Verapamil


    ENVARSUS XR is not interchangeable with other tacrolimus products. Never switch products without speaking with your doctor first.

    Speak with your doctor if you have a history of these conditions:

    • Diabetes
    • Hyperkalemia
    • Hypertension
    • Neurotoxicity
    • QT prolongation

    Do not get live vaccinations while taking ENVARSUS XR unless directed by your doctor.

    Your doctor should monitor you for Pure Red Cell Aplasia while taking ENVARSUS XR

    Side Effects

    Some of the common ENVARSUS XR side effects may include:

    • Anemia
    • Constipation
    • Diabetes Mellitus
    • Diarrhea
    • Headache
    • Hyperkalemia
    • Hypertension
    • Increased blood creatinine
    • Peripheral edema
    • Tremor
    • Urinary tract infection


    1. Envarsus XR [package insert]. Cary, NC: Veloxis Pharmaceuticals; 2018.

    Fact Table







    Legal status

    RX Only

    Chemical Name


    Elimination half-life

    11.3 h for transplant patients (range 3.5–40.6 h)

    Dosage (Strength)

    0.75mg (30 tablets), 1mg (30 tablets), 4mg (30 tablets)


    Consult a doctor


    Advagraf, Astagraf, Envarsus, Modigraf, Prograf, Protopic

    Protein binding

    Greater than and equal to 98.8%

    PubChem CID






    ATC code

    D11AH01, L04AD02




    D00107, C01375

    Routes of administration

    By mouth (tablets)

    Frequently Asked Questions about Envarsus XR (Tacrolimus)

    What is Envarsus XR (Tacrolimus)?

    Envarsus XR (Tacrolimus) is a prescription medication used to prevent organ rejection in people who have received a kidney transplant. It belongs to a class of drugs known as immunosuppressants.

    How does Envarsus XR work to prevent organ rejection?

    Envarsus XR works by suppressing the immune system's response to prevent it from attacking the transplanted organ. This helps prevent rejection and allows the transplanted organ to function effectively.

    When should I take Envarsus XR?

    Envarsus XR is usually taken once daily, in the morning or evening, consistently at the same time each day. Your healthcare provider will prescribe the appropriate dose and schedule for you.

    Are there any common side effects of Envarsus XR?

    Common side effects of Envarsus XR may include headache, diarrhea, high blood pressure, and tremors. It's essential to report any unusual or severe side effects to your healthcare provider.

    Can I take other medications along with Envarsus XR?

    Envarsus XR may interact with certain medications, including over-the-counter drugs and supplements. Inform your healthcare provider about all the medications you are taking to avoid potential interactions.

    How should I store Envarsus XR?

    Envarsus XR should be stored at room temperature, away from moisture and heat. Keep it out of reach of children.

    What should I do if I miss a dose of Envarsus XR?

    If you miss a dose of Envarsus XR, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

    Can I drink alcohol while taking Envarsus XR?

    It's advisable to limit alcohol consumption while taking Envarsus XR, as excessive alcohol use may interact with the medication and affect your liver function.

    How long should I continue taking Envarsus XR after my kidney transplant?

    The duration of Envarsus XR treatment will be determined by your healthcare provider based on your individual health and the success of your kidney transplant. Follow their recommendations for the full course of treatment.

    Is Envarsus XR safe during pregnancy or breastfeeding?

    Envarsus XR may harm an unborn baby. If you are pregnant or planning to become pregnant, discuss the risks and benefits of continuing the medication with your healthcare provider. It is not recommended during breastfeeding.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13271

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