What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Envarsus XR (Tacrolimus)

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Brand

Envarsus XR (Tacrolimus)

Prescription Required

Strength
Qty
0.75mg
1mg
4mg

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  • Product Details

    Description

    ENVARSUS XR (tacrolimus) is a medication prescribed for people who have received kidney transplants. It prevents organ rejection by suppressing the immune system.

    When people receive kidney transplants, their body does not recognize the foreign organ and tries to attack it. ENVARSUS XR prevents the activation of T-cells, which are cells of the immune system that attack foreign bodies.

    ENVARSUS XR requires careful monitoring by the doctor to ensure correct blood levels.

    Directions

    The prescribing doctor will determine the appropriate dose. Take it exactly as prescribed by the doctor and do not adjust the dose.

    Ingredients

    The active ingredient in ENVARSUS XR is tacrolimus.

    Interactions

    ENVARSUS XR and other forms of tacrolimus have many drug-drug interactions. Some of these interactions can be toxic, and some can decrease the drug levels until it is ineffective, which can cause organ rejection. Never start, stop, or change the drugs you are taking without talking with your doctor and pharmacist first.

    • Alcohol
    • Amiodarone
    • Anticonvulsants
    • Azole antifungals
    • Boceprevir
    • Carbamazepine
    • Chloramphenicol
    • Cimetidine
    • Clarithromycin
    • Diltiazem
    • Ethinyl Estradiol
    • Danazol
    • Lansoprazole
    • Magnesium and aluminum antacids
    • Methylprednisolone
    • Metoclopramide
    • Mycophenolic acid
    • Nefazodone
    • Nelfinavir
    • Nicardipine
    • Nifedipine
    • Omeprazole
    • Phenobarbital
    • Prednisone
    • Rifabutin
    • Rifampin
    • Ritonavir
    • St. John's Wort
    • Telaprevir
    • Troleandomycin
    • Verapamil

    Cautions

    ENVARSUS XR is not interchangeable with other tacrolimus products. Never switch products without speaking with your doctor first.

    Speak with your doctor if you have a history of these conditions:

    • Diabetes
    • Hyperkalemia
    • Hypertension
    • Neurotoxicity
    • QT prolongation

    Do not get live vaccinations while taking ENVARSUS XR unless directed by your doctor.

    Your doctor should monitor you for Pure Red Cell Aplasia while taking ENVARSUS XR

    Side Effects

    Some of the common ENVARSUS XR side effects may include:

    • Anemia
    • Constipation
    • Diabetes Mellitus
    • Diarrhea
    • Headache
    • Hyperkalemia
    • Hypertension
    • Increased blood creatinine
    • Peripheral edema
    • Tremor
    • Urinary tract infection

    References

    1. Envarsus XR [package insert]. Cary, NC: Veloxis Pharmaceuticals; 2018.


    Fact Table

    Formula

    C44H69NO12

    License

    AU, EU EMA, US FDA

    Bioavailability

    24%

    Legal status

    RX Only

    Chemical Name

    Tacrolimus

    Elimination half-life

    11.3 h for transplant patients (range 3.5–40.6 h)

    Dosage (Strength)

    0.75mg (30 tablets), 1mg (30 tablets), 4mg (30 tablets)

    Pregnancy

    Consult a doctor

    Brands

    Advagraf, Astagraf, Envarsus, Modigraf, Prograf, Protopic

    Protein binding

    Greater than and equal to 98.8%

    PubChem CID

    445643

    MedlinePlus

    a601117

    ChEBI

    61049

    ATC code

    D11AH01, L04AD02

    DrugBank

    DB00864

    KEGG

    D00107, C01375

    Routes of administration

    By mouth (tablets)
    Dr Conor Sheehy
    About Dr. Conor Sheehy (Page Author)

    Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13271

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