Description
ENVARSUS XR (tacrolimus) is a medication prescribed for people who have received kidney transplants. It prevents organ rejection by suppressing the immune system.
When people receive kidney transplants, their body does not recognize the foreign organ and tries to attack it. ENVARSUS XR prevents the activation of T-cells, which are cells of the immune system that attack foreign bodies.
ENVARSUS XR requires careful monitoring by the doctor to ensure correct blood levels.
Directions
The prescribing doctor will determine the appropriate dose. Take it exactly as prescribed by the doctor and do not adjust the dose.
Ingredients
The active ingredient in ENVARSUS XR is tacrolimus.
Interactions
ENVARSUS XR and other forms of tacrolimus have many drug-drug interactions. Some of these interactions can be toxic, and some can decrease the drug levels until it is ineffective, which can cause organ rejection. Never start, stop, or change the drugs you are taking without talking with your doctor and pharmacist first.
- Alcohol
- Amiodarone
- Anticonvulsants
- Azole antifungals
- Boceprevir
- Carbamazepine
- Chloramphenicol
- Cimetidine
- Clarithromycin
- Diltiazem
- Ethinyl Estradiol
- Danazol
- Lansoprazole
- Magnesium and aluminum antacids
- Methylprednisolone
- Metoclopramide
- Mycophenolic acid
- Nefazodone
- Nelfinavir
- Nicardipine
- Nifedipine
- Omeprazole
- Phenobarbital
- Prednisone
- Rifabutin
- Rifampin
- Ritonavir
- St. John's Wort
- Telaprevir
- Troleandomycin
- Verapamil
Cautions
ENVARSUS XR is not interchangeable with other tacrolimus products. Never switch products without speaking with your doctor first.
Speak with your doctor if you have a history of these conditions:
- Diabetes
- Hyperkalemia
- Hypertension
- Neurotoxicity
- QT prolongation
Do not get live vaccinations while taking ENVARSUS XR unless directed by your doctor.
Your doctor should monitor you for Pure Red Cell Aplasia while taking ENVARSUS XR
Side Effects
Some of the common ENVARSUS XR side effects may include:
- Anemia
- Constipation
- Diabetes Mellitus
- Diarrhea
- Headache
- Hyperkalemia
- Hypertension
- Increased blood creatinine
- Peripheral edema
- Tremor
- Urinary tract infection
References
- Envarsus XR [package insert]. Cary, NC: Veloxis Pharmaceuticals; 2018.
Fact Table |
Formula |
C44H69NO12 |
License |
AU, EU EMA, US FDA |
Bioavailability |
24% |
Legal status |
RX Only |
Chemical Name |
Tacrolimus |
Elimination half-life |
11.3 h for transplant patients (range 3.5–40.6 h) |
Dosage (Strength) |
0.75mg (30 tablets), 1mg (30 tablets), 4mg (30 tablets) |
Pregnancy |
Consult a doctor |
Brands |
Advagraf, Astagraf, Envarsus, Modigraf, Prograf, Protopic |
Protein binding |
Greater than and equal to 98.8% |
PubChem CID |
445643 |
MedlinePlus |
a601117 |
ChEBI |
61049 |
ATC code |
D11AH01, L04AD02 |
DrugBank |
DB00864 |
KEGG |
D00107, C01375 |
Routes of administration |
By mouth (tablets) |
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13271