What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Estrofem (Estradiol)


Estrofem (Estradiol)

Prescription Required


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  • Product Details


    Estrofem is a prescription medication used for hormone replacement therapy (HRT) in women experiencing menopause and for preventing osteoporosis. It contains estradiol, a synthetic version of the hormone estrogen, which plays a vital role in various physiological processes.

    Your doctor may prescribe Estrofem to alleviate menopausal symptoms such as hot flashes, night sweats, vaginal dryness, and mood swings. By replenishing estrogen levels, Estrofem helps restore hormonal balance and improve the quality of life for women going through this transitional phase.


    The usual dosage is 0.5-2 mg, taken by mouth once daily. It can be taken with or without food.

    Do not stop taking this drug without speaking with your healthcare provider.


    The active ingredient in Estrofem is estradiol.


    There are many possible drug-drug interactions, including:

    • Amobarbital
    • Amprenavir
    • Anastrozole
    • Atazanavir
    • Butalbital
    • Carbamazepine
    • Darunavir
    • Exemestane
    • Fosamprenavir
    • Grapefruit juice
    • HIV protease inhibitors (e.g., ritonavir)
    • Indinavir
    • Letrozole
    • Lopinavir
    • Nelfinavir
    • Pentobarbital
    • Phenobarbital
    • Phenytoin
    • Rifampicin
    • Ritonavir
    • Saquinavir
    • Secobarbital
    • St. John's wort
    • Tamoxifen
    • Tipranavir


    Before starting Estrofem, discuss the risks and benefits of hormone therapy with your doctor.

    Certain medical conditions, such as a history of blood clots, liver disease, or breast cancer, may contraindicate the use of Estrofem.

    Also, inform your healthcare provider about any medications or supplements you are taking, as they may interact with Estrofem.

    You should have regular check-ups and monitoring of HRT to ensure its continued safety and effectiveness.

    The risk of blood clots, strokes, breast cancer, and ovarian cancer may be increased in some women that take estrogen for the treatment of menopause symptoms.

    Side Effects

    Common adverse effects can include:

    • Abdominal pain
    • Breast tenderness or enlargement
    • Dizziness
    • Headache
    • Nausea
    • Vaginal bleeding or spotting
    • Vaginal discharge
    • Vaginal itching or irritation
    • Weight changes


    Estrofem [package insert]. City, ST: Novo Nordisk; 2016.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13839

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