A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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EVOTAZ is a prescription medicine used to treat HIV-1 (Human Immunodeficiency Virus) infection in adults. A complete treatment regimen of EVOTAZ in combination with other antiretroviral drugs is important to properly treat HIV:
The following medicines and herbals may cause serious, life-threatening side effects if taken with EVOTAZ: Prescription medicines alfuzosin (Uroxatral®) carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®) cisapride (Propulsid®, Propulsid® Quicksolv®) colchicine (Mitigare®, Colcrys®) if you have liver or kidney problems dronedarone hydrochloride (Multaq®) drospirenone/ethinyl estradiol (Beyaz®, Safyral®, Yasmin®, Yaz®) elbasvir/grazoprevir (Zepatier®) glecaprevir/pibrentasvir (Mavyret®) indinavir (Crixivan®) irinotecan (Camptosar®) lovastatin (Advicor®, Altoprev®, Mevacor®) lurasidone (Latuda®) midazolam (Versed®) when taken by mouth for sedation nevirapine (Viramune®, Viramune XR®) phenobarbital (Luminal®) phenytoin (Dilantin®, Phenytek®) pimozide (Orap®) ranolazine (Ranexa®) rifampin (Rimactane®, Rifadin®, Rifater®, Rifamate®) sildenafil (Revatio®) when used for lung problems simvastatin (Zocor®, Vytorin®, Simcor®) triazolam (Halcion®) Herbals St. John’s Wort (Hypericum perforatum) Prescription medicines containing ergot Cafergot® D.H.E. 45® Embolex® Ergomar® Ergostat® Medihaler® Methergine® Migergot® Migranal® Wigraine® Wigrettes
The common moderate-to-severe side effects of EVOTAZ seen in a clinical study are: 6% or 21 of 344 patients experienced yellowing of the skin 5% or 17 of 344 patients experienced a skin rash 4% or 14 of 344 patients experienced yellowing of the white parts of the eyes 2% or 7 of 344 patients experienced nausea 2% or 7 of 344 patients experienced diarrhea 2% or 7 of 344 patients experienced headache EVOTAZ can cause serious side effects, including: EVOTAZ If you develop any of these symptoms call a healthcare provider right away: EVOTAZ A change in the way your heart beats (Arrhythmia) Symptoms of heart rhythm change may include: dizziness or light headedness. EVOTAZ Skin rash Skin rashes are common with EVOTAZ and can be severe. Skin rashes often go away within two weeks without any change in treatment. Severe rash may develop with other symptoms which could be serious. If you develop a severe rash with any of the following symptoms, call your healthcare provider or go to the nearest hospital emergency room right away: general feeling of discomfort or “flu-like” symptoms; fever; muscle or joint aches; red or inflamed eyes; blisters; mouth sores; swelling of your face; or a painful, warm, or red lump under your skin. EVOTAZ Kidney problems Taking EVOTAZ with certain drugs can cause kidney problems, including kidney failure, to appear or get worse. Kidney stones have also happened in people taking atazanavir, which is a part of EVOTAZ. Symptoms of kidney problems may include: pain in your low back or low stomach area, blood in your urine, or pain when you urinate. EVOTAZ Chronic kidney disease EVOTAZ may affect how well your kidneys work. Your healthcare provider will do blood and urine tests to check your kidneys before you start EVOTAZ and during treatment. EVOTAZ Gallbladder problems Gallbladder problems have appeared in people taking atazanavir. Noticeable symptoms may include: Yellowing of the skin or the white part of your eyes, pain in the right or middle upper stomach area, fever, nausea and vomiting. EVOTAZ Liver problems Liver problems, such as hepatitis B or C may get worse. Noticeable symptoms may include: Yellowing of the skin or the white part of your eyes, dark (“tea colored”) urine, light colored stools, itching, pain in the stomach area, and nausea. Your prescribing physician will do blood tests before and during your treatment on EVOTAZ to check liver function. EVOTAZ Yellowing of the skin or the white part of your eyes This may happen due to increases in bilirubin levels (a byproduct of the liver). EVOTAZ Changes in your immune system (Immune Reconstitution Syndrome) General inflammatory responses and other autoimmune responses can appear when you start taking HIV medicines. EVOTAZ Diabetes and high blood sugar (hyperglycemia) Diabetes and high blood sugar have appeared, or gotten worse, in some people who take protease inhibitor drugs like atazanavir in EVOTAZ. You may need to start using a diabetes drug or change diabetes drugs that you are already on. EVOTAZ Changes in body fat Changes in the amount and distribution of body fat may appear in people taking HIV drugs. The exact cause and long-term health effects are still unknown. EVOTAZ If you have hemophilia Protease inhibitors, such as atazanavir in EVOTAZ, have been known to cause increased bleeding in hemophilia patients.