Description
Femseven is a hormone replacement therapy (HRT) patch containing estradiol hemihydrate, a form of the natural human estrogen estradiol. It is indicated for the treatment of estrogen deficiency symptoms in postmenopausal women, including hot flushes, night sweats, sleep disturbances, and vaginal atrophy. By delivering estradiol transdermally, Femseven provides a steady and controlled release of hormone into the bloodstream, bypassing hepatic metabolism and minimizing fluctuations in hormone levels. It is also used as part of osteoporosis prevention in postmenopausal women who are at high risk of fractures and unable to use other osteoporosis medications.
| Fact Table |
| Formula | C18H24O2·½H2O |
| License | EMA, MHRA |
| Bioavailability | ~50% (transdermal) |
| Legal status | Prescription only |
| Chemical Name | Estradiol hemihydrate |
| Elimination half-life | 13–20 hours (transdermal) |
| Dosage (Strength) | 25 mcg, 37.5 mcg, 50 mcg, 75 mcg, 100 mcg per day (transdermal patch) |
| Pregnancy | Contraindicated |
| Brands | Femseven Mono, Femseven Sequi, Estraderm MX |
| Protein binding | 98% |
| PubChem CID | 5757 |
| MedlinePlus | a605042 |
| ChEBI | 16469 |
| ATC code | G03CA03 |
| DrugBank | DB00783 |
| KEGG | D00196 |
| Routes of administration | Transdermal |
Directions
Femseven patches should be applied once weekly to a clean, dry, and hairless area of the lower abdomen or buttocks, rotating application sites to prevent skin irritation. The patch should be pressed firmly in place for at least 10 seconds to ensure adhesion. It should not be applied to the breasts or broken skin. Continuous or cyclic administration may be used depending on the presence or absence of a uterus and the patient's treatment goals, as directed by a healthcare provider.
Ingredients
The active ingredient in Femseven is estradiol hemihydrate. Each transdermal patch delivers a specified dose of estradiol over 24 hours. Inactive components include the adhesive matrix, backing film, and protective liner designed to ensure proper adhesion and hormone release.
Contraindications
Femseven is contraindicated in women with current or past breast cancer, known or suspected estrogen-dependent malignant tumors, untreated endometrial hyperplasia, active or previous venous thromboembolism, arterial thromboembolic disease (e.g., angina, myocardial infarction), severe liver disease, or porphyria. It must not be used during pregnancy or lactation.
Cautions
Femseven should be used with caution in patients with a history of or risk factors for cardiovascular disease, cerebrovascular conditions, hypertriglyceridemia, liver disorders, gallbladder disease, or endometriosis. Women with a history of depression should be closely monitored. Smoking increases the risk of adverse cardiovascular events and should be avoided. Periodic re-evaluation of the need for continued therapy is essential, with consideration of the lowest effective dose for the shortest duration consistent with treatment goals.
Side Effects
Possible side effects include:
- Application site reactions (e.g., redness, itching, irritation)
- Breast tenderness or pain
- Nausea and abdominal discomfort
- Mood swings or depressive symptoms
- Irregular uterine bleeding or spotting
Serious side effects may include venous thromboembolism, stroke, myocardial infarction, and an increased risk of hormone-sensitive cancers.
Frequently Asked Questions about Femseven (Estradiol Hemihydrate)
How quickly does Femseven start working?
Relief from menopausal symptoms such as hot flashes and night sweats may begin within a few days to a few weeks after starting Femseven, although full benefits can take up to several weeks. Response time can vary depending on individual hormone levels and symptom severity.
Can Femseven help with mood swings or depression?
Femseven may help stabilize mood in some women by addressing hormone-related emotional changes during menopause. However, it is not a primary treatment for clinical depression, and any persistent mood issues should be evaluated by a healthcare provider.
Is weight gain a side effect of Femseven?
While some women report weight changes during hormone therapy, studies do not conclusively link Femseven to significant weight gain. Weight fluctuations may result from hormonal shifts, aging, or lifestyle changes rather than the medication itself.
Can Femseven be used after a hysterectomy?
Yes, Femseven can be used by women who have had a hysterectomy, and in such cases, it is typically prescribed without a progestogen since there is no risk of endometrial buildup in the absence of a uterus.
What should I do if I forget to change my Femseven patch?
If you forget to change your patch, apply a new one as soon as you remember. Resume your regular schedule from that day. Do not use two patches at once to make up for a missed dose.
How long can I stay on Femseven?
The duration of Femseven use depends on the individual's needs, symptom control, and health risks. It should be reviewed regularly with a healthcare provider, with the goal of using the lowest effective dose for the shortest duration necessary.
Can Femseven be used during perimenopause?
Femseven is generally prescribed for postmenopausal women, but in some cases, it may be used during late perimenopause if symptoms are severe and confirmed by hormonal testing, under close medical supervision.
Does Femseven affect menstrual bleeding?
Femseven may cause irregular bleeding or spotting, especially during the first few months of use or when combined with a progestogen. Any unusual or persistent bleeding should be evaluated by a healthcare provider.
Can I bathe or swim while wearing the Femseven patch?
Yes, Femseven is designed to be water-resistant and should remain in place during bathing, swimming, or showering. However, it is recommended to check that the patch is still securely attached afterward.
What lifestyle habits support Femseven therapy?
A healthy lifestyle—including regular exercise, a balanced diet rich in calcium and vitamin D, no smoking, and limiting alcohol—can enhance the benefits of Femseven, particularly for bone and cardiovascular health.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 15341
Prescription Required
