Forteo (Teriparatide)

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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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    Description

    Forteo (teriparatide) is a recombinant form of parathyroid hormone (PTH 1-34) indicated for the treatment of osteoporosis in adults at high risk for fracture. It stimulates new bone formation by activating osteoblasts, increasing bone mineral density and reducing the incidence of vertebral and non-vertebral fractures. Forteo is commonly prescribed for postmenopausal women with osteoporosis, men with primary or hypogonadal osteoporosis, and patients with osteoporosis associated with long-term systemic glucocorticoid therapy. It is administered as a once-daily subcutaneous injection.

    Directions

    Forteo should be administered by subcutaneous injection into the thigh or abdominal wall once daily at a dose of 20 micrograms. Patients should be instructed in proper injection technique and advised to take the injection at the same time each day. The treatment duration should not exceed 24 months over a patient’s lifetime. Forteo should be stored in a refrigerator at 2°C to 8°C and discarded 28 days after first use, even if the pen is not empty.

    Ingredients

    Each dose of Forteo contains:

    • Teriparatide (rDNA origin) 20 micrograms per 80 microliter dose
    • Other ingredients: glacial acetic acid, sodium acetate (anhydrous), mannitol, metacresol, and water for injection

    Contraindications

    Forteo is contraindicated in patients with:

    • Hypersensitivity to teriparatide or any component of the formulation
    • Hypercalcemia or metabolic bone diseases other than osteoporosis
    • A history of skeletal malignancies or bone metastases
    • Paget’s disease of bone
    • Unexplained elevations of alkaline phosphatase
    • Prior external beam or implant radiation therapy involving the skeleton

    Cautions

    Forteo should be used with caution in patients with a history of urolithiasis due to the potential for transient hypercalciuria. Baseline and periodic monitoring of serum calcium, uric acid, and urinary calcium may be warranted. The product has been associated with an increased incidence of osteosarcoma in animal studies, although this has not been confirmed in humans. Forteo is not recommended for use in pediatric patients or young adults with open epiphyses.

    Side Effects

    Common and potential side effects include:

    • Nausea
    • Dizziness or orthostatic hypotension shortly after injection
    • Arthralgia or muscle cramps
    • Hypercalcemia
    • Injection site reactions such as pain, redness, or swelling
    • Headache

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 6662

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