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Foundayo (Orforglipron)

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  • Product Details

    Description

    Foundayo (orforglipron) is an oral prescription tablet used with a reduced-calorie diet and increased physical activity for chronic weight management in adults. It is prescribed for adults with obesity, or for adults who are overweight and have at least one weight-related health condition such as high blood pressure, high cholesterol, or type 2 diabetes.

    Foundayo belongs to a class of medications called GLP-1 receptor agonists. It works by mimicking a natural hormone that regulates appetite and digestion, reducing hunger, increasing feelings of fullness, and slowing the rate at which the stomach empties. Together, these effects help patients eat less and maintain weight loss over time.

    Unlike some other oral weight loss medications, Foundayo can be taken at any time of day, with or without food, and without any water restrictions.

    Fact Table

    Formula

    C48H48F2N10O5

    License

    FDA approved (U.S., April 1, 2026)

    Bioavailability

    77% absolute oral bioavailability (0.8 mg dose); no clinically relevant food effect

    Legal status

    Prescription only (Rx-only, U.S.)

    Chemical Name

    Orforglipron

    Elimination half-life

    29–49 hours

    Dosage (Strength)

    0.8 mg, 2.5 mg, 5.5 mg, 9 mg, 14.5 mg, and 17.2 mg oral tablets; start 0.8 mg once daily, titrate at ≥30-day intervals; max 17.2 mg once daily

    Pregnancy

    Not recommended during pregnancy; discontinue upon confirmed pregnancy.

    Brands

    Foundayo

    Protein binding

    >99%

    PubChem CID

    137319706

    MedlinePlus

    Not assigned

    ChEBI

    Not publicly specified

    ATC code

    None assigned

    DrugBank

    DB18964

    KEGG

    D12536

    Routes of administration

    Oral

    Directions

    The recommended starting dose of Foundayo is 0.8 mg taken orally once daily. The dose is increased gradually over time to improve tolerability. Doses may be increased in steps no sooner than every 30 days, up to a maximum of 17.2 mg once daily based on individual response.

    Swallow tablets whole. Do not break, crush, or chew them. Foundayo may be taken at any time of day, with or without food.

    If a dose is missed, take it as soon as possible. Do not take two doses on the same day. If treatment is interrupted for 7 or more consecutive days, contact your healthcare provider before restarting.

    Ingredients

    The active ingredient of Foundayo is orforglipron.

    Inactive ingredients include copovidone, crospovidone, magnesium stearate, microcrystalline cellulose, and sodium carbonate anhydrous. The film coating contains polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.

    Cautions

    Foundayo should not be used by patients with a personal or family history of medullary thyroid carcinoma (MTC), or by patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

    Do not take Foundayo if you have a known hypersensitivity to orforglipron or any of its inactive ingredients.

    Inform your healthcare provider if you have a history of pancreatitis, kidney problems, severe liver impairment, severe stomach problems such as gastroparesis, or diabetic retinopathy.

    Foundayo may reduce the effectiveness of oral birth control pills. An alternative method of contraception may be recommended for 30 days after starting treatment and for 30 days after each dose increase.

    Foundayo is not recommended during pregnancy or while breastfeeding. Discuss all medications, allergies, and medical conditions with your doctor before beginning treatment.

    Side Effects

    The most common side effects of Foundayo include nausea, abdominal pain, heartburn, constipation, diarrhea, bloating, gas, vomiting, indigestion, belching, headache, fatigue, and temporary hair loss.

    Serious side effects may include inflammation of the pancreas (pancreatitis), gallbladder problems, acute kidney injury, low blood sugar when used alongside other blood sugar–lowering medications, severe allergic reactions, and changes in vision in patients with type 2 diabetes.

    Stop taking Foundayo and contact your healthcare provider right away if you experience severe or persistent abdominal pain, signs of an allergic reaction, or any symptoms that concern you. This is not a complete list of all possible side effects.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 15540

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