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Fruzaqla (Fruquintinib)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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    Description

    Fruzaqla (fruquintinib) is an oral, selective inhibitor of vascular endothelial growth factor receptors (VEGFR-1, -2, and -3). It works by blocking angiogenesis, a process essential for tumor growth and metastasis. Approved by the U.S. FDA in 2023, Fruzaqla is intended for adult patients with metastatic colorectal cancer (mCRC) who have previously received standard treatments including fluoropyrimidine, oxaliplatin, irinotecan, anti-VEGF therapy, and, if RAS wild-type, anti-EGFR therapy. It provides a targeted treatment option with a manageable safety profile for patients who have progressed on multiple lines of therapy.

    Directions

    The recommended dose of Fruzaqla is 5 mg taken orally once daily, with or without food, for the first 21 days of each 28-day cycle. Treatment should continue until disease progression or unacceptable toxicity. Tablets must be swallowed whole—do not crush or chew. Dose modifications may be necessary based on side effects, lab results, or patient tolerance. Monitoring of blood pressure, liver function, and protein levels in urine is recommended throughout treatment.

    Ingredients

    Each Fruzaqla tablet contains:

    • Fruquintinib 5 mg

    Inactive ingredients include:

    • Microcrystalline cellulose
    • Croscarmellose sodium
    • Magnesium stearate
    • Film-coating agents to support stability and bioavailability

    Contraindications

    Fruzaqla is contraindicated in patients with:

    • Known hypersensitivity to fruquintinib or any component of the formulation
    • Severe hepatic impairment without appropriate assessment
    • Recent major surgery, due to risk of impaired wound healing

    Cautions

    Fruzaqla may increase the risk of hypertension, bleeding, thromboembolic events, gastrointestinal perforation, and liver toxicity. Baseline liver function and blood pressure should be evaluated before starting treatment and monitored regularly. Caution is advised in patients with cardiovascular conditions, gastrointestinal issues, or bleeding disorders. Effective contraception should be used during treatment and for at least two weeks after the last dose. Fruzaqla is not recommended during pregnancy or breastfeeding due to potential risks to the fetus or infant.

    Side Effects

    Common and potential side effects include:

    • Hypertension
    • Palmar-plantar erythrodysesthesia (hand-foot syndrome)
    • Proteinuria
    • Diarrhea
    • Fatigue
    • Decreased appetite
    • Nausea and vomiting
    • Elevated liver enzymes
    • Rare: Hemorrhage, gastrointestinal perforation, thromboembolism

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 14893

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