What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Gabitril (Tiagabinet)
Prescription Required
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Product Details
Description
Gabitril is a medication prescribed to treat focal seizure disorders.
Focal seizures are seizures that start in one part of the brain and spread to other regions. Some people experience "fully aware focal seizures" and are still conscious and aware of having a seizure while it's happening (simple partial seizure). Others may lose consciousness or not be aware of the seizure, called a complex partial seizure.
Symptoms may include muscle contractions, eye movements, stomach pain, numbness, or contractions on one side of the body.
Gabitril works by enhancing the activity of the neurotransmitter gamma-aminobutyric acid (GABA). GABA suppresses signals in nerve cells, including the type of signals that cause seizures.
Fact Table
Formula
C20H25NO2S2
License
US FDA
Bioavailability
90–95%
Legal status
Rx only
Chemical Name
Tiagabine
Elimination half-life
5–8 hours
Dosage (Strength)
5mg,10mg
Pregnancy
Consult Doctor
Brands
Gabitril
Protein binding
96%
PubChem CID
60648
MedlinePlus
a698014
ChEBI
9586
ATC code
N03AG06
DrugBank
DB00906
KEGG
D08588
Routes of administration
Oral (tablets)
Directions
Take Gabitril exactly as directed by your doctor.
The starting Gabitril dosage is typically 4 mg by mouth once daily. Your doctor may increase the dosage by 4-8 mg each week. The maximum daily dosage is 56 mg divided two to four times throughout the day.
Ingredients
The active ingredient in Gabitril is tiagabine.
Interactions
Tell your doctor if you are taking any of the following:
- Alcohol
- Apalutamide
- Azelastine
- Brimonidine
- Bromperidol
- Buprenorphine
- Cannabinoid-Containing Products
- Carbamazepine
- Chlormethiazole
- CNS Depressants
- Codeine
- Doxylamine
- Enzalutamide
- Erdafitinib
- Fentanyl
- Flunitrazepam
- Fosphenytoin
- Hydrocodone
- Hydromorphone
- Hydroxyzine
- Kava kava
- Lumacaftor
- Lumacaftor-ivacaftor
- Magnesium Sulfate
- Mefloquine
- Metoclopramide
- Mitotane
- Morphine
- Orlistat
- Orphenadrine
- Oxomemazine
- Oxycodone
- Oxymorphone
- Phenobarbital
- Phenytoin
- Primidone
- Rifampin (rifampicin)
- Suvorexant
- Thalidomide
- Tocilizumab
The above medications have the potential to interact with Gabitril.Cautions
Gabitril can cause CNS depression, so use caution if you are mixing with other CNS depressants.
Do not stop Gabitril without talking with your doctor. Doing so can increase the risk of seizures.
Ask your doctor or pharmacist for a complete list of precautions that apply to you.
Side Effects
Common adverse reactions to Gabitril medication may include:
- Accidental injury
- Dizziness
- Drowsiness
- Infection
- Lack of concentration
- Nausea
- Nervousness
- Tremor
- Weakness
References
- Gabitril [package insert]. Frazer, PA: Cephalon; 2009.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 5481
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