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The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Gelnique (Oxybutynin Chloride)

Also Known as Topical Gel


Gelnique (Oxybutynin Chloride)

Prescription Required

10% 30 Gel Packets

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  • Product Details


    Gelnique 10 Gel Sachets

    Gelnique is a topical prescription used to treat overactive bladder. It is an anti-muscarinic agent that relaxes the bladder's smooth muscle.

    Fact Table







    Legal status

    US: Rx-only and OTC

    Chemical Name

    Oxybutynin Chloride

    Elimination half-life

    12.4–13.2 hours

    Dosage (Strength)



    No Known Risk



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    Transdermal gel


    Apply three pumps of Gelnique once daily to clean and dry skin of the abdomen, thighs, or shoulders.


    The active ingredient in Gelnique is oxybutynin chloride.


    Common interactions may include:

    • Acetylcholinesterase Inhibitors
    • Aclidinium
    • Alcohol (Ethyl)
    • Amantadine
    • Anticholinergic Agents
    • Botulinum Toxin-Containing Products
    • Cannabinoid-Containing Products
    • Chloral Betaine
    • Cimetropium
    • CloZAPine
    • CYP3A4 Inhibitors
    • Eluxadoline
    • Erythromycin
    • Gastrointestinal Agents
    • Glucagon
    • Glycopyrrolate
    • Glycopyrronium
    • Ipratropium
    • Itopride
    • Levosulpiride
    • Mianserin
    • Mirabegron
    • Nitroglycerin
    • Opioid Agonists
    • Oxatomide
    • Potassium Chloride
    • Potassium Citrate
    • Pramlintide
    • Ramosetron
    • Revefenacin
    • Secretin
    • Thiazide and Thiazide-Like Diuretics
    • Tiotropium
    • Topiramate
    • Umeclidinium


    Be careful to avoid skin-to-skin contact with others at the site of application.

    The gel is alcohol-based and flammable. Avoid open flames until the gel has dried.

    Ask your doctor or pharmacist about other precautions.

    Side Effects

    Adverse effects may include:

    • Abdominal pain
    • Agitation
    • Anaphylaxis
    • Angioedema
    • Anorexia
    • Application site dermatitis
    • Application site erythema
    • Application site pruritus
    • Application site rash
    • Application site reaction
    • Application site vesicles
    • Arthralgia
    • Asthenia
    • Asthma
    • Back pain
    • Blurred vision
    • Bronchitis
    • Cardiac arrhythmia
    • Chest discomfort
    • Coated tongue
    • Confusion
    • Constipation
    • Cough
    • Cystitis
    • Decreased blood pressure
    • Decreased gastrointestinal motility
    • Delirium
    • Diarrhea
    • Dizziness
    • Drowsiness 
    • Dry eye syndrome
    • Dry nose
    • Dry throat
    • Dysgeusia
    • Dyspepsia
    • Dysphagia
    • Dysuria
    • Edema
    • Eructation
    • Eye irritation
    • Falling
    • Fatigue
    • Fixed drug eruption
    • Flank pain 
    • Flatulence
    • Fluid retention
    • Flushing
    • Fungal infection 
    • Gastroesophageal reflux disease
    • Glaucoma
    • Hallucination
    • Headache
    • Heatstroke
    • Hoarseness
    • Hot flash
    • Hypertension
    • Hypertonia
    • Hypohidrosis
    • Increased blood pressure
    • Increased liver enzymes
    • Increased post-void residual urine volume
    • Increased serum glucose
    • Increased thirst 
    • Insomnia
    • Limb pain 
    • Macular eruption
    • Memory impairment
    • Mydriasis
    • Nasal congestion
    • Nasopharyngitis
    • Nausea
    • Nervousness
    • Oropharyngeal pain
    • Pain 
    • Palpitations
    • Paranasal sinus congestion
    • Peripheral edema
    • Pharyngolaryngeal pain
    • Pollakiuria
    • Prolonged QT interval on ECG
    • Pruritus
    • Psychotic reaction
    • Seizure
    • Sinoatrial nodal rhythm disorder 
    • Sinus headache
    • Tachycardia
    • Upper abdominal pain
    • Upper respiratory tract infection
    • Urinary hesitancy
    • Urinary retention
    • Urinary tract infection 
    • Viral gastroenteritis
    • Visual disturbance
    • Voice disorder
    • Vomiting
    • Xeroderma
    • Xerostomia 


    Gelnique [package insert]. Parsippany, NJ: Watson Pharma, Inc.; 2013.

    Frequently Asked Questions about Gelnique (Oxybutynin Chloride)

    What is Gelnique used for?

    Gelnique is used to treat symptoms of an overactive bladder such as loss of bladder control, frequent need to urinate, and urge urinary incontinence.

    How does Gelnique work?

    Gelnique works by relaxing muscles in the bladder, acting as a muscarinic antagonist and antispasmodic drug.

    How is Gelnique administered?

    Gelnique is a quick-drying, colorless topical gel that should be applied to the skin, but not on recently shaved skin surfaces.

    What are the common side effects of Gelnique?

    Common side effects include skin irritation where the gel was applied, dry mouth, constipation, itching, and tiredness.

    Are there any serious side effects associated with Gelnique?

    Some serious side effects have been seen with drugs containing oxybutynin, like Gelnique, including dizziness, blurred vision, and drowsiness, which may be increased with alcohol consumption, and decreased sweating that may lead to overheating.

    Can Gelnique be used with other medications?

    Glenique can interact with drugs that make you sleepy, drugs that irritate the stomach, antihistamines, and antifungals

    Is Gelnique available over the counter or does it require a prescription?

    Gelnique requires a prescription to be bought

    What should I do if I miss a dose?

    If you miss a dose, use it as soon as you can, otherwise if it's time for your next dose, then apply it only once. Do not use double or extra doses.

    What should I do in case of an overdose?

    Though you can't overdose on a topical gel, it's still harmful if swallowed. Call 911 or a local poison center if you happen to have swalled some and have trouble breathing.

    Can pregnant or breastfeeding women use Gelnique?

    There aren't enough studies to conclude if Gelnique will have an effect on a pregnant or breastfeeding woman. Talk to your doctor, and they may recommend a separate, safer approach.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 11602

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