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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Gleostine (Lomustine)

Also Known as Ceenu

Brand

Gleostine (Lomustine)

Prescription Required

Strength
Qty
10mg
40mg

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  • Product Details

    Description

    GLEOSTINE (lomustine) is prescribed to treat certain types of cancers. It is a chemotherapy agent, and should only be used under the close supervision of a physician.

    GLEOSTINE can be prescribed for the following types of cancers:

    • Brain tumors; primary and metastatic tumors.
    • Hodgkin's lymphoma, following disease progression with initial chemotherapy.


    GLEOSTINE attaches to DNA and RNA, preventing the replication of cancerous cells. GLEOSTINE also attaches to specific proteins, making them inactive.

    Directions

    The normal dose of GLEOSTINE is 130 mg per meter-squared, rounded to the nearest 5 mg.

    GLEOSTINE is available in the following capsule sizes:

    • 5 mg
    • 10 mg
    • 40 mg
    • 100 mg


    One single dose of GLEOSTINE is administered every six weeks.

    Ingredients

    The active ingredient in GLEOSTINE is lomustine.


    Fact Table

    Formula

    C9H16ClN3O2

    License

    -

    Bioavailability

    100%

    Legal status

    RX Only

    Chemical Name

    Lomustine

    Elimination half-life

    Approximately 94 minutes, Metabolites have a serum half-life of 16 to 48 hours

    Dosage (Strength)

    10mg (20 tablets), 40mg (20 tablets)

    Pregnancy

    Consult a doctor

    Brands

    Ceenu, Gleostine

    Protein binding

    50%

    PubChem CID

    3950

    MedlinePlus

    a682207

    ChEBI

    6520

    ATC code

    L01AD02

    DrugBank

    DB01206

    KEGG

    D00363

    Routes of administration

    By mouth (tablets)

    Interactions

    Speak with your healthcare provider if you are taking any of the following:

    • Baracitinib
    • BCG (Bacillus Calmette-Guerin)
    • Chloramphenicol
    • Cladribine
    • Clozapine
    • Coccidiodes immitis Skin Test
    • Deferiprone
    • Denosumab
    • Dipyrone
    • Echinacea
    • Fingolimod
    • Inebilizumab
    • Leflunomide
    • Lenograstim
    • Lipegfilgrastim
    • Mesalamine
    • Natalizumab
    • Nivolumab
    • Ocrelizumab
    • Ozanimod
    • Palifermin
    • Pidotimod
    • Pimecrolimus
    • Promazine
    • Roflumilast
    • Siponimod
    • Sipuleucel-T
    • Tacrolimus
    • Tertomotide
    • Tofacitinib
    • Trastuzumab
    • Upadacitinib
    • Vaccines

    Cautions

    An overdose of GLEOSTINE can be fatal. Take GLEOSTINE exactly as directly once every six weeks.

    GLEOSTINE can cause myelosuppression (bone marrow suppression), which is a decrease in the activity of bone marrow cells. Complete blood counts need to be monitored regularly while taking GLEOSTINE.

    GLEOSTINE should not be used by women who are pregnant or breastfeeding.

    GLEOSTINE can cause lung toxicity. Lung function should be monitored while taking this medication.

    Long-term use can cause secondary malignancies.

    Monitor liver function and kidney function while taking GLEOSTINE.

    Side Effects

    Common adverse reactions to GLEOSTINE may include:

    • Alopecia
    • Ataxia
    • Blindness
    • Disorientation
    • Dysarthria
    • Lethargy
    • Nausea
    • Optic atrophy
    • Stomatitis
    • Visual disturbances
    • Vomiting

    References

    Gleostine [package insert].Miami, FL: NextSource Biotechnology; 2016.


    Frequently Asked Questions about Gleostine

    What is Gleostine?

    Gleostine, also known as Lomustine, is an oral chemotherapy drug used to treat certain types of cancer, including brain tumors and Hodgkin's disease.

    How does Gleostine work?

    Gleostine works by interfering with the growth and spread of cancer cells in the body. It belongs to a class of drugs known as alkylating agents.

    How is Gleostine taken?

    Gleostine is taken orally in capsule form. The dosage and frequency will be determined by your doctor based on your medical condition and response to treatment.

    What are the side effects of Gleostine?

    Common side effects may include nausea, vomiting, loss of appetite, and decreased blood cell counts. It's essential to report any unusual or severe side effects to your doctor immediately.

    Can I take other medications while on Gleostine?

    Always inform your doctor of all the medications you are taking, including over-the-counter drugs and supplements. Some drugs may interact with Gleostine, affecting its efficacy or increasing side effects.

    What precautions should I take while on Gleostine?

    Due to the potential for decreased blood cell counts, it's essential to avoid contact with sick individuals and practice good hygiene. Regular blood tests may be required to monitor your health.

    Is Gleostine safe during pregnancy?

    Gleostine can harm an unborn baby. It's crucial to use effective birth control while taking this medication and for a certain period after the last dose. Consult your doctor for specific recommendations.

    Can I drink alcohol while taking Gleostine?

    It's best to discuss this with your doctor. Alcohol may exacerbate some side effects of Gleostine.

    How should I store Gleostine?

    Store Gleostine at room temperature, away from moisture and heat. Keep it out of reach of children and pets.

    What should I do if I miss a dose?

    If you miss a dose, contact your doctor for guidance. Do not double up on doses to make up for a missed one.


    Dr Conor Sheehy
    About Dr. Conor Sheehy (Page Author)

    Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13265

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