What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Gleostine (Lomustine)
Prescription Required
We don't have this generic product yet!
Sign up to get exclusive coupon discounts and be the first to be notified when we have this product available.
-
Product Details
Description
GLEOSTINE (lomustine) is prescribed to treat certain types of cancers. It is a chemotherapy agent, and should only be used under the close supervision of a physician.
GLEOSTINE can be prescribed for the following types of cancers:
- Brain tumors; primary and metastatic tumors.
- Hodgkin's lymphoma, following disease progression with initial chemotherapy.
GLEOSTINE attaches to DNA and RNA, preventing the replication of cancerous cells. GLEOSTINE also attaches to specific proteins, making them inactive.Directions
The normal dose of GLEOSTINE is 130 mg per meter-squared, rounded to the nearest 5 mg.
GLEOSTINE is available in the following capsule sizes:
- 5 mg
- 10 mg
- 40 mg
- 100 mg
One single dose of GLEOSTINE is administered every six weeks.Ingredients
The active ingredient in GLEOSTINE is lomustine.
Fact Table
Formula
C9H16ClN3O2
License
-
Bioavailability
100%
Legal status
RX Only
Chemical Name
Lomustine
Elimination half-life
Approximately 94 minutes, Metabolites have a serum half-life of 16 to 48 hours
Dosage (Strength)
10mg (20 tablets), 40mg (20 tablets)
Pregnancy
Consult a doctor
Brands
Ceenu, Gleostine
Protein binding
50%
PubChem CID
3950
MedlinePlus
a682207
ChEBI
6520
ATC code
L01AD02
DrugBank
DB01206
KEGG
D00363
Routes of administration
By mouth (tablets)
Interactions
Speak with your healthcare provider if you are taking any of the following:
- Baracitinib
- BCG (Bacillus Calmette-Guerin)
- Chloramphenicol
- Cladribine
- Clozapine
- Coccidiodes immitis Skin Test
- Deferiprone
- Denosumab
- Dipyrone
- Echinacea
- Fingolimod
- Inebilizumab
- Leflunomide
- Lenograstim
- Lipegfilgrastim
- Mesalamine
- Natalizumab
- Nivolumab
- Ocrelizumab
- Ozanimod
- Palifermin
- Pidotimod
- Pimecrolimus
- Promazine
- Roflumilast
- Siponimod
- Sipuleucel-T
- Tacrolimus
- Tertomotide
- Tofacitinib
- Trastuzumab
- Upadacitinib
- Vaccines
Cautions
An overdose of GLEOSTINE can be fatal. Take GLEOSTINE exactly as directly once every six weeks.
GLEOSTINE can cause myelosuppression (bone marrow suppression), which is a decrease in the activity of bone marrow cells. Complete blood counts need to be monitored regularly while taking GLEOSTINE.
GLEOSTINE should not be used by women who are pregnant or breastfeeding.
GLEOSTINE can cause lung toxicity. Lung function should be monitored while taking this medication.
Long-term use can cause secondary malignancies.
Monitor liver function and kidney function while taking GLEOSTINE.
Side Effects
Common adverse reactions to GLEOSTINE may include:
- Alopecia
- Ataxia
- Blindness
- Disorientation
- Dysarthria
- Lethargy
- Nausea
- Optic atrophy
- Stomatitis
- Visual disturbances
- Vomiting
References
Gleostine [package insert].Miami, FL: NextSource Biotechnology; 2016.
Frequently Asked Questions about Gleostine
What is Gleostine?
Gleostine, also known as Lomustine, is an oral chemotherapy drug used to treat certain types of cancer, including brain tumors and Hodgkin's disease.
How does Gleostine work?
Gleostine works by interfering with the growth and spread of cancer cells in the body. It belongs to a class of drugs known as alkylating agents.
How is Gleostine taken?
Gleostine is taken orally in capsule form. The dosage and frequency will be determined by your doctor based on your medical condition and response to treatment.
What are the side effects of Gleostine?
Common side effects may include nausea, vomiting, loss of appetite, and decreased blood cell counts. It's essential to report any unusual or severe side effects to your doctor immediately.
Can I take other medications while on Gleostine?
Always inform your doctor of all the medications you are taking, including over-the-counter drugs and supplements. Some drugs may interact with Gleostine, affecting its efficacy or increasing side effects.
What precautions should I take while on Gleostine?
Due to the potential for decreased blood cell counts, it's essential to avoid contact with sick individuals and practice good hygiene. Regular blood tests may be required to monitor your health.
Is Gleostine safe during pregnancy?
Gleostine can harm an unborn baby. It's crucial to use effective birth control while taking this medication and for a certain period after the last dose. Consult your doctor for specific recommendations.
Can I drink alcohol while taking Gleostine?
It's best to discuss this with your doctor. Alcohol may exacerbate some side effects of Gleostine.
How should I store Gleostine?
Store Gleostine at room temperature, away from moisture and heat. Keep it out of reach of children and pets.
What should I do if I miss a dose?
If you miss a dose, contact your doctor for guidance. Do not double up on doses to make up for a missed one.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13265
-
Product Reviews
