What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Glumetza (Metformin Extended Release)


Glumetza (Metformin Extended Release)

Prescription Required


You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

Generic Equivalent - Glumetza (Metformin Extended Release)

Prescription Required


You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

  • Product Details


    Glumetza 500 & 1000mg Glumetza (metformin extended release)

    If you have type 2 diabetes mellitus, your doctor may have prescribed Glumetza. In people with type 2 diabetes mellitus, their bodies are less sensitive to the insulin made by their pancreas. Insulin is responsible for moving glucose into cells and providing them with energy. When insulin isn't working, the cells don't get the energy they need. Also, extra glucose in the blood damages blood vessels.

    Glumetza works by making cells more sensitive to the insulin already there.

    Fact Table







    Legal status


    Chemical Name


    Elimination half-life

    4–8.7 hours

    Dosage (Strength)

    500mg, 1000mg


    No Known Risk


    Glucophage, Glumetza

    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth


    The usual dosage is 500-2000 mg per day. Dosages can be divided once or twice a day.

    Take Glumetza with food to lessen the side effects.


    The active ingredient in Glumetza is metformin.


    The most common drug-drug interactions may include:

    • Abemaciclib
    • Alcohol
    • Alpha-Lipoic Acid
    • Androgens
    • Beta-Blockers
    • Bortezomib
    • Carbonic Anhydrase Inhibitors
    • Cephalexin
    • Cimetidine
    • Dalfampridine
    • Direct Acting Antiviral Agents
    • Dofetilide
    • Dolutegravir
    • Erdafitinib
    • Etilefrine
    • Fexinidazole
    • Fludeoxyglucose F 18
    • Gilteritinib
    • Glycopyrrolate
    • Guanethidine
    • Guar Gum
    • Hyperglycemia-Associated Agents
    • Hypoglycemia-Associated Agents
    • Iodinated Contrast Agents
    • LamoTRIgine
    • Maitake
    • MATE1/2-K Inhibitors
    • Monoamine Oxidase Inhibitors
    • Nonsteroidal Anti-Inflammatory Agents
    • Ombitasvir, Paritaprevir, and Ritonavir
    • Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir
    • Ondansetron
    • Pacritinib
    • Patiromer
    • Pegvisomant
    • Prothionamide
    • Quinolones
    • Ranolazine
    • Risdiplam
    • Ritodrine
    • Salicylates
    • Selective Serotonin Reuptake Inhibitors
    • Tafenoquine
    • Thiazide and Thiazide-Like Diuretics
    • Topiramate
    • Verapamil
    • Vitamin K Antagonists


    Glumetza may need to be paused during surgery.

    Extended-release metformin may remain intact and visible in the stool.

    Tell your doctor if you have a history of kidney or liver problems. 

    Side Effects

    If you are experiencing any of the following, it may be a side effect of metformin:

    • Abdominal distension
    • Abdominal distress
    • Abdominal pain
    • Abnormal stools
    • Asthenia
    • Chest discomfort
    • Chills
    • Diaphoresis
    • Diarrhea 
    • Dizziness
    • Dyspepsia 
    • Dyspnea
    • Encephalopathy
    • Fixed drug eruption 
    • Flatulence 
    • Flu-like symptoms
    • Flushing
    • Headache
    • Heartburn
    • Hemolytic anemia
    • Hepatic injury
    • Hypoglycemia
    • Lactic acidosis
    • Lichen planus
    • Myalgia
    • Nail disease
    • Nausea and vomiting 
    • Palpitations
    • Upper respiratory tract infection
    • Vitamin B12 deficiency


    Glumetza [package insert]. Menlo Park, CA: Depomed, Inc; 2009.

    Frequently Asked Questions about Glumetza (Metformin Extended Release)

    What is Glumetza used for?

    Glumetza is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It's sometimes used with insulin or other medications.

    How should Glumetza be taken?

    Swallow the extended-release tablet whole. Do not crush, break, or chew it. Inform your doctor if you have trouble swallowing the tablets whole.

    What is the drug class of Glumetza?

    Glumetza belongs to the drug class Biguanide, and it's a form of Metformin Extended Release.

    What are some common brand names for Metformin Extended Release?

    Glumetza, Glucophage XR, and Fortamet are common brand names for Metformin Extended Release.

    What should I do if I have an allergic reaction to Glumetza?

    If you have an allergic reaction to Glumetza, discontinue use and seek medical attention.

    Is Glumetza suitable for treating type 1 diabetes?

    No, Glumetza is not for treating type 1 diabetes.

    What are the forms of Glumetza available?

    Glumetza is available in the form of tablets, including extended-release tablets, and an extended-release suspension.

    What is the generic name for Glumetza?

    The generic name for Glumetza is Metformin Hydrochloride.

    What are the contraindications for Glumetza?

    Do not use Glumetza if you've had an allergic reaction to Metformin. It's important to keep all medicine out of the reach of children.

    Where should Glumetza be stored?

    Keep Glumetza out of the reach of children, and store it in a safe place to prevent misuse.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 11509

  • Product Reviews


Please wait while the page is loading. Do not hit refresh or the browser back button to avoid any loss of information.

If you have any questions or concerns, please contact our Customer Service team via the chat option on our website or calling us toll free at: 1-800-891-0844