What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Glumetza (Metformin Extended Release)
Generic Equivalent - Glumetza (Metformin Extended Release)
Prescription Required
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Product Details
Description
Glumetza (metformin extended release)
If you have type 2 diabetes mellitus, your doctor may have prescribed Glumetza. In people with type 2 diabetes mellitus, their bodies are less sensitive to the insulin made by their pancreas. Insulin is responsible for moving glucose into cells and providing them with energy. When insulin isn't working, the cells don't get the energy they need. Also, extra glucose in the blood damages blood vessels.
Glumetza works by making cells more sensitive to the insulin already there.
Fact Table
Formula
C4H11N5
License
US FDA, EU EMA
Bioavailability
50–60%
Legal status
Rx-only
Chemical Name
Metformin
Elimination half-life
4–8.7 hours
Dosage (Strength)
500mg, 1000mg
Pregnancy
No Known Risk
Brands
Glucophage, Glumetza
Protein binding
Minimal
PubChem CID
4091
MedlinePlus
a696005
ChEBI
6801
ATC code
A10BA02
DrugBank
DB00331
KEGG
D04966
Routes of administration
By mouth
Directions
The usual dosage is 500-2000 mg per day. Dosages can be divided once or twice a day.
Take Glumetza with food to lessen the side effects.
Ingredients
The active ingredient in Glumetza is metformin.
Interactions
The most common drug-drug interactions may include:
- Abemaciclib
- Alcohol
- Alpha-Lipoic Acid
- Androgens
- Beta-Blockers
- Bortezomib
- Carbonic Anhydrase Inhibitors
- Cephalexin
- Cimetidine
- Dalfampridine
- Direct Acting Antiviral Agents
- Dofetilide
- Dolutegravir
- Erdafitinib
- Etilefrine
- Fexinidazole
- Fludeoxyglucose F 18
- Gilteritinib
- Glycopyrrolate
- Guanethidine
- Guar Gum
- Hyperglycemia-Associated Agents
- Hypoglycemia-Associated Agents
- Iodinated Contrast Agents
- LamoTRIgine
- Maitake
- MATE1/2-K Inhibitors
- Monoamine Oxidase Inhibitors
- Nonsteroidal Anti-Inflammatory Agents
- Ombitasvir, Paritaprevir, and Ritonavir
- Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir
- Ondansetron
- Pacritinib
- Patiromer
- Pegvisomant
- Prothionamide
- Quinolones
- Ranolazine
- Risdiplam
- Ritodrine
- Salicylates
- Selective Serotonin Reuptake Inhibitors
- Tafenoquine
- Thiazide and Thiazide-Like Diuretics
- Topiramate
- Verapamil
- Vitamin K Antagonists
Cautions
Glumetza may need to be paused during surgery.
Extended-release metformin may remain intact and visible in the stool.
Tell your doctor if you have a history of kidney or liver problems.
Side Effects
If you are experiencing any of the following, it may be a side effect of metformin:
- Abdominal distension
- Abdominal distress
- Abdominal pain
- Abnormal stools
- Asthenia
- Chest discomfort
- Chills
- Diaphoresis
- Diarrhea
- Dizziness
- Dyspepsia
- Dyspnea
- Encephalopathy
- Fixed drug eruption
- Flatulence
- Flu-like symptoms
- Flushing
- Headache
- Heartburn
- Hemolytic anemia
- Hepatic injury
- Hypoglycemia
- Lactic acidosis
- Lichen planus
- Myalgia
- Nail disease
- Nausea and vomiting
- Palpitations
- Upper respiratory tract infection
- Vitamin B12 deficiency
References
Glumetza [package insert]. Menlo Park, CA: Depomed, Inc; 2009.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11509
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