What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Glyxambi (Empagliflozin/Linagliptin)
Prescription Required
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Product Details
Description
Your doctor may prescribe Glyxambi if you have type 2 diabetes mellitus. Glyxambi should not be prescribed for people with type 1 diabetes mellitus.
Type 2 diabetes is a chronic condition where a person does not have enough insulin to meet their metabolic needs. This can happen through a combination of insulin resistance and decreased pancreatic function.
Fact Table
Formula
Empagliflozin: C23H27ClO7 Linagliptin: C25H28N8O2
License
US DailyMed
Bioavailability
Empagliflozin: Approximately 78% Linagliptin: Approximately 30%
Legal status
Rx-Only
Chemical Name
Empagliflozin/Linagliptin
Elimination half-life
Empagliflozin: Approximately 12.4 hours Linagliptin: Approximately 12 hours
Dosage (Strength)
10mg / 5mg, 25mg / 5mg
Pregnancy
Consult Doctor
Brands
Glyxambi
Protein binding
Empagliflozin: Approximately 86% Linagliptin: Approximately 99%
PubChem CID
Empagliflozin: 11949646 Linagliptin: 10096344
MedlinePlus
Not listed
ChEBI
Empagliflozin: 82795 Linagliptin: 65369
ATC code
A10BD19
DrugBank
Empagliflozin: DB09038 Linagliptin: DB08882
KEGG
Empagliflozin: D10459 Linagliptin: D09566
Routes of administration
Oral
Directions
Take one tablet by mouth once daily. Glyxambi is available in 10/5 mg and 25/5 mg formulations.
Glyxambi can be taken with or without food. It should be taken at the same time every day.
Ingredients
The active ingredients in Glyxambi are empagliflozin and linagliptin.
Empagliflozin works by increasing the amount of glucose excreted through the urine.
Linagliptin works by causing the body to release more insulin and decreasing the amount of glucose that the liver makes.
Interactions
Potential drug-drug interactions with this medication can include:
- Apalutamide
- Carbamazepine
- Enzalutamide
- Fosphenytoin
- Lumacaftor
- Lumacaftor-ivacaftor
- Mitotane
- Phenobarbital
- Phenytoin
- Primidone
- Rifampin (rifampicin)
- Insulins
- Carbamazepine
- Clotrimazole
- Dexamethasone
- Fosamprenavir
- Indinavir
- Morphine
- Nelfinavir
- Phenobarbital
- Phenothiazines
- Phenytoin
- Prazosin
- Retinoic acid
- Rifampin
- Ritonavir
- Saquinavir
- St. John's Wort
- Spironolactone
- Tipranavir
- Sulfonylureas
Tell your doctor and pharmacist if you are taking any of the above medications before starting Glyxambi.Cautions
Use caution if you have a history of pancreatitis.
Tell your doctor if you have a history of kidney or liver problems.
Tell your doctor if you have a history of low blood pressure before starting this medication.
This drug can increase the risk of urinary tract infections and yeast infections.
Side Effects
Common Glyxambi side effects may include:
- Acute kidney injury
- Bullous pemphigoid
- Fournier's gangrene
- Hypoglycemia
- Increased hematocrit
- Increased serum cholesterol
- Nasopharyngitis
- Rhabdomyolysis
- Severe arthralgia
- Skin rash
- Upper respiratory tract infection
- Urinary tract infection
References
- Glyxambi [package insert]. Indianapolis, IN: Eli Lilly and Company; 2015.
Frequently Asked Questions about Glyxambi (Empagliflozin/Linagliptin)
What is Glyxambi (Empagliflozin/Linagliptin)?
Glyxambi is a prescription medication that combines two active ingredients, Empagliflozin and Linagliptin. It is used to treat type 2 diabetes in adults by helping to lower blood sugar levels.
How does Glyxambi work to control blood sugar?
Glyxambi works in two ways. Empagliflozin helps the kidneys remove excess glucose from the bloodstream through urine, while Linagliptin increases the release of insulin and reduces the production of glucose in the liver.
Is Glyxambi suitable for all individuals with type 2 diabetes?
Glyxambi may not be suitable for everyone with type 2 diabetes. Your healthcare provider will assess your specific condition and medical history to determine if Glyxambi is the right treatment for you.
How should I take Glyxambi?
Glyxambi is typically taken orally once a day, with or without food. It's essential to follow your healthcare provider's instructions and take the medication as prescribed.
What are the potential side effects of Glyxambi?
Common side effects of Glyxambi can include urinary tract infections, increased urination, genital yeast infections, and upper respiratory tract infections. It's crucial to report any unusual or severe side effects to your doctor.
Can I take other medications along with Glyxambi?
Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Glyxambi. Your doctor can determine the safest treatment regimen for you.
Is Glyxambi a cure for type 2 diabetes?
No, Glyxambi is not a cure for type 2 diabetes. It is a medication used to help manage and control blood sugar levels. Type 2 diabetes is a chronic condition that typically requires ongoing treatment and lifestyle modifications.
Can I consume alcohol while taking Glyxambi?
It is generally safe to consume alcohol in moderation while taking Glyxambi. However, discuss alcohol use with your healthcare provider, as excessive alcohol intake can affect blood sugar levels.
How long will I need to take Glyxambi?
The duration of Glyxambi treatment will be determined by your healthcare provider based on your response to the medication and the management of your diabetes. It may be a long-term treatment.
Is Glyxambi safe to use during pregnancy or while breastfeeding?
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using Glyxambi. They can assess the potential risks and benefits and provide guidance on the best course of action.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13224
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