Grastofil (Filgrastim)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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Prescription Required

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    Your doctor may prescribe Grastofil to reduce the risk of infections in individuals undergoing immune-suppressive therapies for various cancer types. Grastofil is indicated for patients with non-myeloid malignancies at significant risk of febrile neutropenia but can also be used to treat acute myeloid leukemia (AML), post-bone marrow transplantation, peripheral blood progenitor cell (PBPC) collection and therapy, severe chronic neutropenia, and HIV infection.

    Grastofil shares structural similarities with granulocyte colony-stimulating factor (G-CSF), a naturally occurring hormone. Its mechanism involves boosting the production of white blood cells within the bone marrow.


    Grasteofil is available in prefilled syringes that are injected under the skin.

    Grastofil is dosed based on the diagnosis and individual patient characteristics. It should be taken exactly as prescribed. Do not stop or adjust treatment without speaking with your healthcare team.


    The active ingredient in Grastofil is filgrastim.


    • Grastofil has no known drug-drug interactions


    To your doctor right away if you experience abdominal or shoulder pain because it could indicate a potential enlarged spleen and the impending risk of splenic rupture—an emergent medical situation.

    Tell your doctor if you have a family or personal history of sickle cell disease.

    Grastofil usage should be avoided 24 hours before or after receiving chemotherapy.

    Tell your doctor if you have a history of latex allergies because the prefilled syringe contains natural latex. In such cases, alternative treatment options should be considered.

    Side Effects

    Common adverse reactions to this drug include:

    • Alopecia
    • Anemia
    • Anaphylaxis
    • Bleeding from nose
    • Blood transfusion reaction
    • Bone pain
    • Capillary leak syndrome
    • Cough
    • Diarrhea
    • Dyspnea
    • Fever
    • Glomerulonephritis
    • Headache
    • Hepatosplenomegaly
    • Hypersensitivity reaction
    • Hypoesthesia
    • Leukocytosis
    • Myelodysplastic syndrome
    • Nausea
    • Pain
    • Pain in limb
    • Pulmonary hemorrhage
    • Rash
    • Rupture of spleen
    • Sepsis
    • Sickle cell anemia with crisis
    • Splenomegaly
    • Thrombocytopenia
    • Vasculitis of the skin


    Grastofil [package insert]. Toronto, ON: Apotex; February 2018.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 14436

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