What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.



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Generic Equivalent - Harvoni (Ledipasvir/Sofosbuvir)

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  • Product Details


    HARVONI (ledipasvir/sofosbuvir) is a medication prescribed to treat chronic hepatitis C (HCV) infection. It may be prescribed with or without the antiviral ribavirin. HARVONI generic is not available at this time.


    Take 1 tablet (ledipasvir 90 mg/sofosbuvir 400 mg) by mouth once daily with or without food.

    The length of treatment will depend on the genetic makeup of the hepatitis C virus causing the infection. The genetic type will also determine if HARVONI should be used in combination with ribavirin. Do not take HARVONI in a way different than prescribed by your doctor.

    The recommended treatment regimens and durations include:

    • Genotype 1, treatment-naive: HARVONI alone for 12 weeks
    • Genotype 1, treatment-experienced without cirrhosis: HARVONI alone for 12 weeks
    • Genotype 1, treatment-experienced with compensated cirrhosis: HARVONI alone for 24 weeks
    • Genotype 1, treatment-naive or treatment-experienced with decompensated cirrhosis: HARVONI with ribavirin for 12 weeks
    • Genotype 1 or 4: treatment-naive or treatment-experienced liver transplant recipients without cirrhosis or with compensated cirrhosis: HARVONI with ribavirin for 12 weeks
    • Genotype 4, 5, 6: Treatment-naive and treatment-experienced without cirrhosis or with compensated cirrhosis: HARVONI alone for 12 weeks

    Your specific directions may be different than the regimens listed above based on the recommendation from your physician.


    HARVONI is a combination of two different antiviral medications, ledipasvir, and sofosbuvir. Together, the drugs use two different pathways to stop the hepatitis C virus from copying itself.


    The hepatitis C virus is made up of genetic material and a protective protein coat. The virus uses the protein NS5A to replicate its genetic material and create more virus particles. Ledipasvir inhibits NS5A, preventing viral replication.


    Hepatitis C viruses also use the protein NS5B RNA-dependent RNA polymerase to replicate its genetic code. Sofosbuvir binds to this protein and stops it from functions.

    Fact Table
    Formula C71H83F3N11O15P
    License US: FDA
    Routes of administration By mouth
    Legal status Rx Only
    Chemical Name Ledipasvir/Sofosbuvir
    Elimination half-life 47 hours, 0.4 hours
    Dosage (Strength) 90mg/400mg, 45mg/200mg
    Pregnancy Not classified yet
    Brands Harvoni
    Protein binding >99.8%, 61-65%
    PubChem CID 72734365
    MedlinePlus a614051
    ChEBI 85089, 85083
    ATC code J05AP51
    DrugBank DB09027, DB08934
    KEGG D10578
    Bioavailability -


    Tell your doctor if you had ever tested positive for the hepatitis B virus. In people with both hepatitis B and hepatitis C infections, hepatitis B virus may reactivate, leading to hepatitis, liver failure, or death.

    Tell your doctor if you are taking the heart rhythm drug amiodarone. People who take both medications may cause the heart to slow (bradycardia). Taking both medications at the same time is not recommended.

    If you have diabetes, the treatment of hepatitis C may improve your blood glucose control. If you are taking medications for diabetes, they may cause hypoglycemia and need to be adjusted.

    Side Effects

    The most common adverse reactions when taking HARVONI include:

    • Asthenia
    • Decreases in hemoglobin
    • Diarrhea
    • Dizziness
    • Fatigue
    • Headache
    • Insomnia
    • Irritability
    • MyalgiaDyspnea
    • Nausea

    The side effects each person experiences will be different based on their disease and other medications they are taking for treatment.

    If you buy HARVONI online from Canada Pharmacy, be sure to tell your plans to your doctor. The HARVONI price may be cheaper when buying online.


    1. Harvoni [package insert]. Foster City, CA: Gilead; 2014.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13249

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