Humira (Adalimumab)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details

    Description

    Humira is a type of medication called a monoclonal antibody. It is a prescription drug that can target specific proteins in the body that lead to autoimmune disease. The following conditions can be treated with Humira:

    • Ankylosing spondylitis
    • Crohn disease
    • Hidradenitis suppurativa
    • Plaque psoriasis
    • Psoriatic arthritis
    • Rheumatoid arthritis
    • Ulcerative colitis
    • Uveitis

    Humira works by binding to TNF-alpha, a protein free-floating in the blood. Normally, TNF-alpha activates many different immune system cells. For people with the above conditions, they have too much activity in their immune system. Humira helps to lower that activity back to normal.

    Fact Table

    Formula

    C6428H9912N1694O1987S46

    License

    US FDA, EU EMA

    Bioavailability

    64%

    Legal status

    Rx-Only

    Chemical Name

    Adalimumab

    Elimination half-life

    3 hour

    Dosage (Strength)

    -

    Pregnancy

    not recommended

    Brands

    Humira

    Protein binding

    Not Available

    PubChem CID

    Not Available

    MedlinePlus

    a603010

    ChEBI

    Not Available

    ATC code

    L04AB04

    DrugBank

    DB00051

    KEGG

    D02597

    Routes of administration

    Subcutaneous

    Directions

    The directions for Humira are determined by your healthcare provider. The Humira dosage varies based on what condition is being treated.

    Use Humira exactly as prescribed by your healthcare provider.

    Humira should be stored in the refrigerator at 36°F to 46°F (2°C to 8°C), and not in the freezer. If brought to room temperature, Humira will last for 14 days.

    Ingredients

    Adalimumab is the active ingredient in Humira.

    Interactions

    Serious drug-drug interactions with Humira include:

    • Abatacept
    • Anakinra
    • BCG
    • Certolizumab
    • Echinacea
    • Fingolimod
    • Inactivated vaccines
    • Leflunomide
    • Live vaccines
    • Natalizumab
    • Pimecrolimus
    • Sipuleucel-T
    • Tacrolimus
    • Tocilizumab
    • Vedolizumab

    Cautions

    Tell your doctor if you have a history of cardiovascular disease or heart failure before taking Humira.

    Tell your doctor if you have a latent infection like hepatitis B or tuberculosis. Humira can reactivate these infections.

    Humira may increase the risk of certain cancers.

    This list is not a full list of the possible precautions while taking Humira. Ask your doctor or pharmacist for precautions that are applicable to you.

    Side Effects

    Common Humira side effects may include:

    • Antibody development
    • Headache
    • Increase creatinine phosphokinase
    • Infections
    • Injection site reaction
    • Positive autoantibody titer
    • Sinusitis
    • Skin rash
    • Upper respiratory tract infection

    References

    1. Humira [package insert].Chicago, IL: Abbvie; 2020.


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 2593

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