Description
Incruse Ellipta is an inhaled medication that is used to treat Chronic Obstructive Pulmonary Disease (COPD). COPD is a group of chronic diseases that includes chronic bronchitis and emphysema.
The symptoms of COPD are progressive and can include shortness of breath, chronic cough, and wheezing.
Incruse Ellipta works by stopping acetylcholine, a neurotransmitter, from activating muscarinic receptors in the smooth muscle of the lungs. This effect causes bronchodilation, which is the relaxation of the airways, and makes it easier to breathe.
Fact Table |
Formula |
C29H34BrNO2 |
License |
EU EMA |
Bioavailability |
13% |
Legal status |
Rx-only |
Chemical Name |
Umeclidinium |
Elimination half-life |
11 hours |
Dosage (Strength) |
55mcg |
Pregnancy |
Consult Doctor |
Brands |
Incruse Ellipta |
Protein binding |
~89% |
PubChem CID |
11519069 |
MedlinePlus |
a614024 |
ChEBI |
79040 |
ATC code |
R03BB07 |
DrugBank |
DB09076 |
KEGG |
D10181 |
Routes of administration |
Inhalation |
Directions
The standard dosage of Incruse Ellipta inhaler is one inhalation once daily.
Incruse Ellipta is a maintenance medication, meaning it must be taken every day to be effective.
Ingredients
The active ingredient in Incruse Ellipta is called umeclidinium.
Interactions
- Aclidinium
- Amantadine
- Atropine
- Benztropine
- Botulinum Toxin-Containing Products
- Chloral Betaine
- Chlorthalidone
- Darifenacin
- Dicyclomine
- Fesoterodine
- Gastrointestinal Agents
- Glucagon
- Glycopyrrolate
- Hydrochlorothiazide
- Hyoscyamine
- Ipratropium
- Mirabegron
- Nitroglycerin
- Oxybutynin
- Potassium Chloride
- Scopolamine
- Solifenacin
- Tiotropium
- Tolterodine
- Topiramate
- Trihexyphenidyl
- Trospium
Cautions
Do not use Incruse Ellipta if you have an allergy to milk proteins.
Incruse Ellipta cannot be used to treat acute symptoms of COPD or for acutely worsening patients. Acute symptoms should be treated with a rescue inhaler like albuterol.
Tell your doctor if you have a history of narrow-angle glaucoma before starting this medication.
Incruse Ellipta can worsen urinary retention in some people.
Side Effects
Every medication has a list of potential side effects. Common Incruse Ellipta side effects can include:
- Arthralgia
- Blurred vision
- Bruise
- Cough
- Dysgeusia
- Dysuria
- Eye pain
- Glaucoma
- Myalgia
- Nasopharyngitis
- Pharyngitis
- Tachycardia
- Toothache
- Upper abdominal pain
- Upper respiratory infection
- Urinary retention
- Viral upper respiratory tract infection
Speak with your doctor and pharmacist about any side effects you experience while using this inhaler.
References
- Incruse Ellipta [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2016.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13204