What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Inspra (Eplerenone)


Inspra (Eplerenone)

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  • Product Details


    INSPRA (Eplerenone) is a prescription medication used to two different types of cardiovascular issues:

    • Hypertension
    • Patients with heart failure and left ventricular systolic dysfunction to improve survival

    INSPRA works by blocking a hormone that increases blood pressure called aldosterone. Normally, aldosterone increases blood pressure by increases how much sodium the kidneys retain when they make urine. By blocking this hormone, the blood pressure is decreased.

    INSPRA works for hypertension by lowering blood pressure. In people with heart failure, it decreases the workload on the heart when blood pressure is lowered.


    Take INSPRA exactly as prescribed by the doctor.

    The dosage of INSPRA depends on the condition being treated:

    • Heart failure: Start with 25 mg by mouth once daily. The dose can be increased to 50 mg by mouth once daily after four weeks.
    • Hypertension: Start with 50 mg by mouth once daily. The dose can be increased to a maximum of 50 mg by mouth twice daily.


    The active ingredient in INSPIRA is eplerenone.

    Fact Table







    Legal status

    RX Only

    Chemical Name


    Elimination half-life

    4-6 hours

    Dosage (Strength)

    25mg (30 tablets), 50mg (30 tablets)


    Consult a doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration



    Some common drug interactions that may happen with INSPRA include:

    • ACE inhibitors
    • Angiotensin Receptor Blockers
    • Erythromycin
    • Fluconazole
    • Lithium
    • NSAIDs
    • Saquinavir
    • Verapamil


    INSPRA can cause high blood potassium (hyperkalemia), especially when taken with other medications that lower blood pressure. Your healthcare provider should check your potassium when starting the medication and periodically to ensure your potassium is a safe level. High potassium can cause heart problems if left untreated.

    Side Effects

    Common INSPRA side effects include:

    • Coughing
    • Diarrhea
    • Dizziness
    • Fatigue
    • Flu-like symptoms
    • Hyperkalemia (high blood potassium)
    • Increased creatinine


    Inspra [package insert].New York, NY: Pfizer; 2002.

    Frequently Asked Questions about Inspra (Eplerenone)

    What is Inspra (Eplerenone)?

    Inspra (Eplerenone) is a medication used to treat heart failure and high blood pressure. It belongs to a class of drugs known as aldosterone antagonists, which work by blocking the action of the hormone aldosterone in the body.

    How should I take Inspra?

    Inspra should be taken as directed by your doctor, usually once or twice a day with or without food. It's important to follow your doctor's dosing instructions carefully and to continue taking the medication even if you feel well.

    What are the potential side effects of Inspra?

    Common side effects may include headache, dizziness, fatigue, and stomach pain. Serious side effects can include hyperkalemia (high potassium levels), dehydration, and kidney problems. Contact your healthcare provider if you experience any unusual or severe side effects.

    Can I take Inspra if I am pregnant or breastfeeding?

    You should consult with your healthcare provider before taking Inspra if you are pregnant, planning to become pregnant, or breastfeeding. The medication may pose risks to the fetus or nursing infant.

    What should I do if I miss a dose?

    If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

    Can I drink alcohol while taking Inspra?

    It's advisable to discuss with your healthcare provider before consuming alcohol while on Inspra, as it may interfere with the effectiveness of the medication or worsen side effects.

    What other medications may interact with Inspra?

    Certain medications, including other blood pressure drugs, potassium supplements, and nonsteroidal anti-inflammatory drugs (NSAIDs), may interact with Inspra. It's important to inform your healthcare provider of all the medications and supplements you are taking.

    How should I store Inspra?

    Inspra should be stored at room temperature, away from light and moisture. Keep the medication in its original packaging and out of reach of children.

    Is there a generic version of Inspra available?

    Yes, a generic version of Inspra (Eplerenone) is available. If you are interested in the generic version, discuss with your healthcare provider to determine if it's a suitable option for you.

    Who should I contact in case of an emergency or overdose?

    In case of an emergency or suspected overdose, contact your local poison control center or seek emergency medical attention immediately.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 5519

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