What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Inspra (Eplerenone)
Prescription Required
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Product Details
Description
INSPRA (Eplerenone) is a prescription medication used to two different types of cardiovascular issues:
- Hypertension
- Patients with heart failure and left ventricular systolic dysfunction to improve survival
INSPRA works by blocking a hormone that increases blood pressure called aldosterone. Normally, aldosterone increases blood pressure by increases how much sodium the kidneys retain when they make urine. By blocking this hormone, the blood pressure is decreased.INSPRA works for hypertension by lowering blood pressure. In people with heart failure, it decreases the workload on the heart when blood pressure is lowered.
Directions
Take INSPRA exactly as prescribed by the doctor.
The dosage of INSPRA depends on the condition being treated:
- Heart failure: Start with 25 mg by mouth once daily. The dose can be increased to 50 mg by mouth once daily after four weeks.
- Hypertension: Start with 50 mg by mouth once daily. The dose can be increased to a maximum of 50 mg by mouth twice daily.
Ingredients
The active ingredient in INSPIRA is eplerenone.
Fact Table
Formula
C24H30O6
License
AU
Bioavailability
70%
Legal status
RX Only
Chemical Name
Eplerenone
Elimination half-life
4-6 hours
Dosage (Strength)
25mg (30 tablets), 50mg (30 tablets)
Pregnancy
Consult a doctor
Brands
Inspra
Protein binding
33-60%
PubChem CID
5282131
MedlinePlus
a603004
ChEBI
31547
ATC code
C03DA04
DrugBank
DB00700
KEGG
D01115
Routes of administration
Oral
Interactions
Some common drug interactions that may happen with INSPRA include:
- ACE inhibitors
- Angiotensin Receptor Blockers
- Erythromycin
- Fluconazole
- Lithium
- NSAIDs
- Saquinavir
- Verapamil
Cautions
INSPRA can cause high blood potassium (hyperkalemia), especially when taken with other medications that lower blood pressure. Your healthcare provider should check your potassium when starting the medication and periodically to ensure your potassium is a safe level. High potassium can cause heart problems if left untreated.
Side Effects
Common INSPRA side effects include:
- Coughing
- Diarrhea
- Dizziness
- Fatigue
- Flu-like symptoms
- Hyperkalemia (high blood potassium)
- Increased creatinine
References
Inspra [package insert].New York, NY: Pfizer; 2002.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 5519
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