What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Intelence (Etravirine)
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Product Details
Description
Intelence is a medication that can be given along with other medications to treat Human Immunodeficiency Virus (HIV) infection. HIV is a long-term condition, and the appropriate treatment can delay Acquired Immunodeficiency Syndrome (AIDS) development.
Intelence is an antiviral medication that works by blocking the enzyme Reverse Transcriptase (RT), which is critical for the replication of HIV viral particles.
Fact Table
Formula
C20H15BrN6O
License
US FDA, EU EMA
Bioavailability
-
Legal status
Rx-only
Chemical Name
Etravirine
Elimination half-life
41± 20 hours
Dosage (Strength)
200mg
Pregnancy
Consult Doctor
Brands
Intelence
Protein binding
99.9%
PubChem CID
193962
MedlinePlus
a608016
ChEBI
63589
ATC code
J05AG04
DrugBank
DB06414
KEGG
D04112
Routes of administration
Oral
Directions
Take Intelence medication exactly as directed by your doctor. Do not abruptly stop taking it.
The standard adult dosage is 200 mg by mouth twice daily after meals.
Ingredients
The active ingredient in Intelence 200 mg, 100 mg, or 25 mg tablets is etravirine.
Interactions
There are many drug interactions that exist for Intelence. Tell your doctor and pharmacist about all the drugs you are taking before starting Intelence.
- Antihepaciviral Combination Products
- Apalutamide
- Avanafil
- Axitinib
- Bosutinib
- Carbamazepine
- Dasabuvir
- Doxorubicin
- Efavirenz
- Elbasvir and Grazoprevir
- Enzalutamide
- Etravirine
- Flibanserin
- Fosamprenavir
- Fosphenytoin
- Ivabradine
- Lumacaftor
- Lumacaftor-ivacaftor
- Mitotane
- Neratinib
- Nevirapine
- Phenobarbital
- Phenytoin
- Pimavanserin
- Primidone
- Ranolazine
- Rifampin (rifampicin)
- Rilpivirine
- St John's Wort
- Venetoclax
- Zanubrutinib
Cautions
Intelence may cause the redistribution of fat tissue around the body.
Intelence may cause immune reconstitution inflammatory syndrome when starting the medication due to reactivation of the immune system.
Tell your doctor immediately if you develop a rash after you start taking Intelence.
Side Effects
Common side effects may include:
- Abdominal distention
- Abnormal dreams
- Amnesia
- Angina pectoris
- Anxiety
- Atrial fibrillation
- Blurred vision
- Bronchospasm
- Confusion
- Decreased white blood cells
- Diabetes mellitus
- Diarrhea
- Disorientation
- Drowsiness
- Facial edema
- Hemolytic anemia
- Hyperhidrosis
- Hypersensitivity reaction
- Immune reconstitution syndrome
- Increased LDL cholesterol
- Increased liver enzymes
- Increased serum glucose
- Increased serum triglycerides
- increased serum cholesterol
- Myocardial infarction
- Nervousness
- Night sweats
- Peripheral neuropathy
- Skin rash
- Syncope
- Tremor
References
- Intelence [package insert]. Titusville NJ: Janssen; 2019
Frequently Asked Questions about Intelence (Etravirine)
What is Intelence (Etravirine)?
Intelence (Etravirine) is a prescription medication used to treat HIV (human immunodeficiency virus) infection. It belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs) and is used in combination with other antiretroviral medications to control HIV.
How does Intelence (Etravirine) work?
Intelence works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of HIV. By doing so, it helps to reduce the viral load in the body and slow down the progression of HIV infection.
What is the recommended dosage of Intelence (Etravirine)?
The recommended dosage of Intelence can vary depending on your individual medical condition and the specific combination of antiretroviral medications prescribed by your healthcare provider. It is crucial to follow your healthcare provider's instructions carefully.
Are there any common side effects associated with Intelence (Etravirine)?
Common side effects of Intelence may include nausea, diarrhea, rash, headache, and changes in liver function. These side effects can vary in intensity and may subside over time. It's essential to report any severe or persistent side effects to your healthcare provider.
Can Intelence (Etravirine) cure HIV?
No, Intelence is not a cure for HIV. It is an antiretroviral medication that helps to control the virus and slow down its progression, but it does not eliminate the virus from the body. HIV remains a chronic condition that requires ongoing treatment.
Is it safe to take Intelence (Etravirine) during pregnancy?
If you are pregnant or planning to become pregnant, it's crucial to discuss your HIV treatment options with your healthcare provider. They can assess the risks and benefits and determine the most appropriate treatment plan for you and your baby.
Can I drink alcohol while taking Intelence?
It's generally recommended to limit alcohol consumption while taking Intelence. Alcohol can interact with certain medications and may affect their effectiveness. Discuss alcohol use with your healthcare provider to ensure it is safe for you.
What should I do if I miss a dose of Intelence?
If you miss a dose of Intelence, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.
Can I switch to Intelence (Etravirine) from another HIV medication?
Switching to Intelence from another HIV medication should only be done under the guidance of a healthcare provider. They will assess your specific situation and ensure a safe transition to Intelence while maintaining effective HIV treatment.
Is it possible to develop resistance to Intelence (Etravirine)?
Yes, like many antiretroviral medications, it is possible to develop resistance to Intelence if it is not taken consistently and as prescribed. To minimize the risk of resistance, it is essential to adhere to your treatment regimen and take the medication as directed.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12624
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