What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Intelence (Etravirine)
Prescription Required
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Product Details
Description
Intelence is a medication that can be given along with other medications to treat Human Immunodeficiency Virus (HIV) infection. HIV is a long-term condition, and the appropriate treatment can delay Acquired Immunodeficiency Syndrome (AIDS) development.
Intelence is an antiviral medication that works by blocking the enzyme Reverse Transcriptase (RT), which is critical for the replication of HIV viral particles.
Fact Table
Formula
C20H15BrN6O
License
US FDA, EU EMA
Bioavailability
-
Legal status
Rx-only
Chemical Name
Etravirine
Elimination half-life
41± 20 hours
Dosage (Strength)
200mg
Pregnancy
Consult Doctor
Brands
Intelence
Protein binding
99.9%
PubChem CID
193962
MedlinePlus
a608016
ChEBI
63589
ATC code
J05AG04
DrugBank
DB06414
KEGG
D04112
Routes of administration
Oral
Directions
Take Intelence medication exactly as directed by your doctor. Do not abruptly stop taking it.
The standard adult dosage is 200 mg by mouth twice daily after meals.
Ingredients
The active ingredient in Intelence 200 mg, 100 mg, or 25 mg tablets is etravirine.
Interactions
There are many drug interactions that exist for Intelence. Tell your doctor and pharmacist about all the drugs you are taking before starting Intelence.
- Antihepaciviral Combination Products
- Apalutamide
- Avanafil
- Axitinib
- Bosutinib
- Carbamazepine
- Dasabuvir
- Doxorubicin
- Efavirenz
- Elbasvir and Grazoprevir
- Enzalutamide
- Etravirine
- Flibanserin
- Fosamprenavir
- Fosphenytoin
- Ivabradine
- Lumacaftor
- Lumacaftor-ivacaftor
- Mitotane
- Neratinib
- Nevirapine
- Phenobarbital
- Phenytoin
- Pimavanserin
- Primidone
- Ranolazine
- Rifampin (rifampicin)
- Rilpivirine
- St John's Wort
- Venetoclax
- Zanubrutinib
Cautions
Intelence may cause the redistribution of fat tissue around the body.
Intelence may cause immune reconstitution inflammatory syndrome when starting the medication due to reactivation of the immune system.
Tell your doctor immediately if you develop a rash after you start taking Intelence.
Side Effects
Common side effects may include:
- Abdominal distention
- Abnormal dreams
- Amnesia
- Angina pectoris
- Anxiety
- Atrial fibrillation
- Blurred vision
- Bronchospasm
- Confusion
- Decreased white blood cells
- Diabetes mellitus
- Diarrhea
- Disorientation
- Drowsiness
- Facial edema
- Hemolytic anemia
- Hyperhidrosis
- Hypersensitivity reaction
- Immune reconstitution syndrome
- Increased LDL cholesterol
- Increased liver enzymes
- Increased serum glucose
- Increased serum triglycerides
- increased serum cholesterol
- Myocardial infarction
- Nervousness
- Night sweats
- Peripheral neuropathy
- Skin rash
- Syncope
- Tremor
References
- Intelence [package insert]. Titusville NJ: Janssen; 2019
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12624
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