Description
Intelence is a medication that can be given along with other medications to treat Human Immunodeficiency Virus (HIV) infection. HIV is a long-term condition, and the appropriate treatment can delay Acquired Immunodeficiency Syndrome (AIDS) development.
Intelence is an antiviral medication that works by blocking the enzyme Reverse Transcriptase (RT), which is critical for the replication of HIV viral particles.
Fact Table |
Formula |
C20H15BrN6O |
License |
US FDA, EU EMA |
Bioavailability |
- |
Legal status |
Rx-only |
Chemical Name |
Etravirine |
Elimination half-life |
41± 20 hours |
Dosage (Strength) |
200mg |
Pregnancy |
Consult Doctor |
Brands |
Intelence |
Protein binding |
99.9% |
PubChem CID |
193962 |
MedlinePlus |
a608016 |
ChEBI |
63589 |
ATC code |
J05AG04 |
DrugBank |
DB06414 |
KEGG |
D04112 |
Routes of administration |
Oral |
Directions
Take Intelence medication exactly as directed by your doctor. Do not abruptly stop taking it.
The standard adult dosage is 200 mg by mouth twice daily after meals.
Ingredients
The active ingredient in Intelence 200 mg, 100 mg, or 25 mg tablets is etravirine.
Interactions
There are many drug interactions that exist for Intelence. Tell your doctor and pharmacist about all the drugs you are taking before starting Intelence.
- Antihepaciviral Combination Products
- Apalutamide
- Avanafil
- Axitinib
- Bosutinib
- Carbamazepine
- Dasabuvir
- Doxorubicin
- Efavirenz
- Elbasvir and Grazoprevir
- Enzalutamide
- Etravirine
- Flibanserin
- Fosamprenavir
- Fosphenytoin
- Ivabradine
- Lumacaftor
- Lumacaftor-ivacaftor
- Mitotane
- Neratinib
- Nevirapine
- Phenobarbital
- Phenytoin
- Pimavanserin
- Primidone
- Ranolazine
- Rifampin (rifampicin)
- Rilpivirine
- St John's Wort
- Venetoclax
- Zanubrutinib
Cautions
Intelence may cause the redistribution of fat tissue around the body.
Intelence may cause immune reconstitution inflammatory syndrome when starting the medication due to reactivation of the immune system.
Tell your doctor immediately if you develop a rash after you start taking Intelence.
Side Effects
Common side effects may include:
- Abdominal distention
- Abnormal dreams
- Amnesia
- Angina pectoris
- Anxiety
- Atrial fibrillation
- Blurred vision
- Bronchospasm
- Confusion
- Decreased white blood cells
- Diabetes mellitus
- Diarrhea
- Disorientation
- Drowsiness
- Facial edema
- Hemolytic anemia
- Hyperhidrosis
- Hypersensitivity reaction
- Immune reconstitution syndrome
- Increased LDL cholesterol
- Increased liver enzymes
- Increased serum glucose
- Increased serum triglycerides
- increased serum cholesterol
- Myocardial infarction
- Nervousness
- Night sweats
- Peripheral neuropathy
- Skin rash
- Syncope
- Tremor
References
- Intelence [package insert]. Titusville NJ: Janssen; 2019
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 12624