What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Invega Sustenna Injection (Paliperidone Palmitate)

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Brand

Invega Sustenna Injection (Paliperidone Palmitate)

Prescription Required

Strength
Qty
39mg / 0.25ml
78mg / 0.5ml (50mg / 0.5ml paliperidone base)
117mg / 0.75ml (75mg / 0.75ml paliperidone base)
156mg / 1ml (100mg / 1ml paliperidone base)
234mg / 1.5ml (150mg / 1.5ml paliperidone base)

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  • Product Details

    Description

    Invega Sustenna is a prescription medication for treating psychiatric disorders, specifically schizophrenia, bipolar disorder, and schizoaffective disorder. It is a long-acting injectable (LAI) antipsychotic that works for 28 days. 

    Invega Sustenna works by alleviating symptoms and improving the overall quality of life for individuals affected by these conditions.


    Fact Table

    Formula

    C23H27FN4O3

    License

    EU EMA, US FDA

    Bioavailability

    28%

    Legal status

    Rx-only

    Chemical Name

    Paliperidone

    Elimination half-life

    23 hours

    Dosage (Strength)

    3mg, 6mg, 9mg

    Pregnancy

    Consult Doctor

    Brands

    Invega

    Protein binding

    74%

    PubChem CID

    115237

    MedlinePlus

    a607005

    ChEBI

    82978

    ATC code

    N05AX13

    DrugBank

    DB01267

    KEGG

    D05339

    Routes of administration

    By mouth

    Directions

    Invega Sustenna is administered through a once-monthly injection given by a healthcare provider.

    The injection is given into the deltoid or gluteal muscle.

    The usual monthly dosage is 39-234 mg once monthly.

    Ingredients

    The active ingredient is paliperidone. 

    During the first month, an injection is given on day 1, day 8, and then on day 29.

    Interactions

    Common drug-drug interactions with Invega Sustenna may include the following:

    • Amobarbital
    • Bosentan
    • Butalbital
    • Carbamazepine
    • Carbamazepine
    • Cimetidine
    • Clarithromycin
    • Diltiazem
    • Domperidone
    • Donepezil
    • Efavirenz
    • Erythromycin
    • Ethallobarbital
    • Fluconazole
    • Grapefruit juice
    • Griseofulvin
    • Itraconazole
    • Ketoconazole
    • Mephobarbital
    • Methadone
    • Methohexital
    • Modafinil
    • Nevirapine
    • Ondansetron
    • Pentobarbital
    • Phenobarbital
    • Phenytoin
    • QT-prolonging drugs
    • Quinine
    • Rifampicin
    • Ritonavir
    • Secobarbital
    • St. John's wort
    • Talbutal
    • Thiopental
    • Tramadol
    • Verapamil

    Cautions

    Before starting Invega Sustenna, tell your doctor about any kidney or liver problems. 

    Your doctor should regularly monitor the levels of blood cells during the course of this medication. 

    Tell your doctor if you have a history of seizures.

    This drug may cause hyperprolactinemia which can lead to gynecomastia or the painful enlargement of breasts.

    Tell your doctor if you have a history of heart problems, diabetes, or any other chronic medical conditions.

    Use caution if you are taking other drugs that treat mental health disorders.

    Side Effects

    The most common side effects of this drug are:

    • Akathisia (restlessness)
    • Anxiety
    • Constipation
    • Dizziness
    • Drowsiness
    • Dry mouth
    • Extrapyramidal symptoms (movement disorders)
    • Headache
    • Increased heart rate
    • Insomnia
    • Nausea
    • Orthostatic hypotension (low blood pressure upon standing)
    • Rash or skin reactions
    • Weight gain

    References

    1. Invega Sustenna [package insert]. Titusville, NJ: Janssen; 2017.


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 11338

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