What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Invokamet (Canagliflozin/metformin)

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Brand

Invokamet (Canagliflozin/metformin)

Prescription Required

Strength
Qty
50/1000mg
50/500mg
150/1000mg
150/500mg

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  • Product Details

    Description

    Invokamet is made up of two medications, canagliflozin and metformin hydrochloride. It's used with diet and exercise to treat adults with type 2 diabetes. Canagliflozin is used to decrease the risk of serious cardiovascular events in adults with type 2 diabetes and heart disease and the risk of end-stage kidney disease, doubling serum creatinine levels, death caused by cardiovascular reasons, and hospitalization for adults with type 2 diabetes, heart failure, and diabetic kidney disease with the presence of albumin in the urine.

    Invokamet should not be used to treat adults with type 1 diabetes as this may increase their risk for a serious condition called diabetic ketoacidosis.

    Directions

    Follow your doctor's instructions and read the information that comes with your Invokamet prescription. Don't hesitate to reach out to your doctor or pharmacist with any questions or concerns you have.

    Invokamet oral tablets are available in the following strengths:

    • Canagliflozin 50 mg and metformin HCl 500 mg
    • Canagliflozin 50 mg and metformin HCl 1,000 mg
    • Canagliflozin 150 mg and metformin HCl 500 mg
    • Canagliflozin 150 mg and metformin HCl 1,000 mg

    The recommended starting dose is Invokamet (canagliflozin 50 mg and metformin 500 mg) by mouth two times a day with meals. The dose may be adjusted based on kidney function and response to the medication.

    Ingredients

    Each Invokamet tablet contains canagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, and metformin, a biguanide. Inactive ingredients include croscarmellose sodium, hypromellose, magnesium stearate, and microcrystalline cellulose. The film-coating is made of macrogol/PEG3350, polyvinyl alcohol (hydrolyzed partially), talc, titanium dioxide, iron oxide yellow (50 mg/1,000 mg and 150 mg/500 mg tablets), iron oxide red (50 mg/1,000 mg, 150 mg/500 mg, and 150 mg/1,000 mg tablets), and iron oxide black (150 mg/1,000 mg tablets).

    Contraindications

    Do not take Invokamet if you have severe kidney problems or if you are on dialysis.

    Do not take Invokamet if you have metabolic acidosis such as diabetic ketoacidosis.

    Do not take Invokamet if you are allergic to canagliflozin, metformin, or any of the other ingredients or excipients contained in Invokamet.

    Cautions

    WARNING: LACTIC ACIDOSIS

    See full prescribing information for complete boxed warning.

    • Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. Symptoms included malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Laboratory abnormalities included elevated blood lactate levels, anion gap acidosis, increased lactate/pyruvate ratio; and metformin plasma levels generally greater than 5 mcg/mL. 
    • Risk factors include renal impairment, concomitant use of certain drugs, age greater than 65 years old, radiological studies with contrast, surgery and other procedures, hypoxic states, excessive alcohol intake, and hepatic impairment. Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided in the Full Prescribing Information.
    • If lactic acidosis is suspected, discontinue INVOKAMET/INVOKAMET XR and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended. 
    • Before you start treatment with Invokamet, be sure to discuss the following with your doctor:
      • All the medications you take, including prescription and over-counter-medications as well as vitamins and herbal supplements.
      • Your allergies
      • Your medical history and current health problems
      • If you are pregnant or have plans to become pregnant
      • If you are breastfeeding or have plans to breastfeed
      • If you have any upcoming imaging procedures
    • Risk of lower limb amputations has been associated with canagliflozin. Talk to your doctor about your risk factors for lower limb amputations before you start taking Invokamet. Call your doctor right away if you have pain, tenderness, sores, or ulcers on your feet.
    • Volume depletion can occur during treatment with Invokamet. Your risk may be greater if you have kidney problems, are elderly, or if you take certain fluid pills. 
    • Ketoacidosis, a severe condition that can be fatal, can occur with the use of Invokamet. Seek emergency care right away if you have nausea, vomiting, stomach pain, general discomfort, and trouble breathing.
    • Urinary tract infections and kidney infections that may require hospitalization can occur with the use of Invokamet. Contact your doctor right away if you have burning upon urination, frequent urination, urination that looks cloudy, bright pink, or red, urine with a strong odor, pelvic pain, fever, nausea, or back pain.
    • Low blood sugar can occur with the use of Invokamet, especially if taken with insulin or other medications that can lower blood sugar. Monitor your blood sugar and treat low blood sugar as your doctor has instructed. 
    • Although rare, necrotizing fasciitis of the perineum (Fournier's gangrene), a severe and potentially fatal necrotizing infection that warrants surgery, can occur during treatment with Invokamet. Seek emergency care right away if you have fever or discomfort and pain, tenderness, redness, or swelling in the general or perineal area. 
    • Genital fungal infections can occur during treatment with Invokamet.
    • Serious allergic reactions can occur with the use of Invokamet. Seek emergency care right away if you have a rash, rapid heart rate, trouble breathing, or swelling of your face, lips, tongue, or throat.
    • Treatment with Invokamet can increase your risk of bone fractures.
    • Treatment with Invokamet can decrease your vitamin B12 levels. 

    Side Effects

    Like with any medication, Invokamet can cause side effects. Although the most common Invokamet side effects are genital fungal infections in women, urinary tract infections, frequent urination, diarrhea, nausea, vomiting, gas, weakness, indigestion, stomach discomfort, and headache, they are not all the possible side effects that can occur during treatment.

    Call your doctor right away if you have side effects that bother you or won't go away. 

    Curious about the Invokamet cost? With a valid prescription, you can buy Invokamet at a competitive cost online at Canada Pharmacy.

    Reference:

    1. Invokamet (canagliflozin and metformin hydrochloride tablets), for oral use. Titusville, NJ: Janssen Pharmaceuticals, Inc.; 2020.



    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13242

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