What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Ismo (Isosorbide Mononitrate)


Ismo (Isosorbide Mononitrate)

Prescription Required


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  • Product Details


    Ismo can be prescribed to treat angina. Angina is a heart condition where blood flow to the heart is reduced, usually by blockages in blood vessels. Common symptoms include shortness of breath, weakness, tiredness, and pressing pain in the chest.

    Fact Table




    US FDA


    More than 95%

    Legal status


    Chemical Name

    Isosorbide mononitrate

    Elimination half-life

    5 hours

    Dosage (Strength)



    Not Recommended


    Monoket, Imdur

    Protein binding

    Less than 5%

    PubChem CID






    ATC code






    Routes of administration

    By mouth


    The usual dosage is 20 mg by mouth twice daily. It should be taken seven hours apart, once upon waking and once again seven hours later. It is critical not to take this medication around the clock (every 12 hours) because this will cause tolerance to build and decrease Ismo's effectiveness.


    The active ingredient in Ismo is Isosorbide Mononitrate.

    Isosorbide is an organic nitrate medication. It works by converting into nitric oxide in the bloodstream, which relaxes the smooth muscle of the blood vessels, causing them to relax. Relaxing the blood vessels increases blood flow and oxygen delivery.


    The most common drug-drug interactions with Ismo include:

    • Alcohol 
    • Dapoxetine
    • Dapsone (Topical)
    • Local Anesthetics
    • Molsidomine
    • Nitric Oxide
    • Prilocaine
    • Riociguat
    • Sildenafil
    • Sodium Nitrite
    • Tadalafil
    • Vardenafil

    Tell your doctor and pharmacist if you are taking any of the above medications before starting Ismo.


    Ismo can cause dizziness and drowsiness. Do not drive or operate machinery until you know how it makes you feel.

    Monitor your heart rate and blood pressure while starting this drug.

    Use caution if you have a history of traumatic brain injury or intracranial hemorrhage (brain bleed).

    Side Effects

    The following is a list of potential Ismo side effects:

    • Chest pain
    • Constipation
    • Diarrhea
    • Dizziness
    • Dry mouth
    • Fainting
    • Flushing
    • Headache
    • Irregular heartbeat
    • Lightheadedness
    • Orthostatic hypotension
    • Pain in joints
    • Shortness of Breath
    • Skin warmth

    Tell your doctor and pharmacist about any side effects you experience while starting this drug.


    1. Ismo [package insert]. Reddy; 2007.

    Frequently Asked Questions about Ismo (Isosorbide Mononitrate)

    What is Ismo (Isosorbide Mononitrate)?

    Ismo is a medication that contains the active ingredient Isosorbide Mononitrate. It belongs to a class of drugs known as nitrates and is commonly used to treat chest pain or angina.

    How does Ismo work?

    Ismo works by relaxing and dilating the blood vessels in the body, which helps to increase blood flow and reduce the workload on the heart. This, in turn, can relieve chest pain (angina) and improve blood flow to the heart.

    What is Ismo used for?

    Ismo is primarily used to prevent and treat angina pectoris, a type of chest pain or discomfort caused by a reduced blood flow to the heart muscles. It can also be prescribed to manage chronic stable angina.

    Can Ismo be used for acute chest pain (heart attack)?

    No, Ismo is not intended for the treatment of acute chest pain or heart attacks. It is used for the prevention and long-term management of stable angina.

    How should I take Ismo?

    Ismo is typically taken orally as directed by a healthcare provider. It is essential to follow the prescribed dosing schedule and not crush or chew the extended-release tablets.

    Are there any common side effects of Ismo?

    Common side effects of Ismo may include headache, dizziness, lightheadedness, nausea, and flushing. These side effects are usually temporary and may improve with continued use.

    Is Ismo safe to take during pregnancy or while breastfeeding?

    Pregnant or breastfeeding individuals should consult with their healthcare provider before taking Ismo, as the potential risks and benefits need to be carefully considered.

    Can I suddenly stop taking Ismo?

    No, it's important not to stop taking Ismo suddenly without consulting your healthcare provider. Abruptly discontinuing Ismo can lead to rebound chest pain or worsened angina symptoms.

    Can I drink alcohol while taking Ismo?

    Alcohol may interact with Ismo and cause a drop in blood pressure, leading to dizziness or fainting. It's advisable to limit or avoid alcohol consumption while taking this medication.

    What should I do if I miss a dose of Ismo?

    If you miss a dose of Ismo, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 1579

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