Description
Ismo can be prescribed to treat angina. Angina is a heart condition where blood flow to the heart is reduced, usually by blockages in blood vessels. Common symptoms include shortness of breath, weakness, tiredness, and pressing pain in the chest.
Fact Table |
Formula |
C6H9NO6 |
License |
US FDA |
Bioavailability |
More than 95% |
Legal status |
Rx-only |
Chemical Name |
Isosorbide mononitrate |
Elimination half-life |
5 hours |
Dosage (Strength) |
20mg |
Pregnancy |
Not Recommended |
Brands |
Monoket, Imdur |
Protein binding |
Less than 5% |
PubChem CID |
27661 |
MedlinePlus |
a682348 |
ChEBI |
6062 |
ATC code |
C01DA14 |
DrugBank |
DB01020 |
KEGG |
D00630 |
Routes of administration |
By mouth |
Directions
The usual dosage is 20 mg by mouth twice daily. It should be taken seven hours apart, once upon waking and once again seven hours later. It is critical not to take this medication around the clock (every 12 hours) because this will cause tolerance to build and decrease Ismo's effectiveness.
Ingredients
The active ingredient in Ismo is Isosorbide Mononitrate.
Isosorbide is an organic nitrate medication. It works by converting into nitric oxide in the bloodstream, which relaxes the smooth muscle of the blood vessels, causing them to relax. Relaxing the blood vessels increases blood flow and oxygen delivery.
Interactions
The most common drug-drug interactions with Ismo include:
- Alcohol
- Dapoxetine
- Dapsone (Topical)
- Local Anesthetics
- Molsidomine
- Nitric Oxide
- Prilocaine
- Riociguat
- Sildenafil
- Sodium Nitrite
- Tadalafil
- Vardenafil
Tell your doctor and pharmacist if you are taking any of the above medications before starting Ismo.
Cautions
Ismo can cause dizziness and drowsiness. Do not drive or operate machinery until you know how it makes you feel.
Monitor your heart rate and blood pressure while starting this drug.
Use caution if you have a history of traumatic brain injury or intracranial hemorrhage (brain bleed).
Side Effects
The following is a list of potential Ismo side effects:
- Chest pain
- Constipation
- Diarrhea
- Dizziness
- Dry mouth
- Fainting
- Flushing
- Headache
- Irregular heartbeat
- Lightheadedness
- Orthostatic hypotension
- Pain in joints
- Shortness of Breath
- Skin warmth
Tell your doctor and pharmacist about any side effects you experience while starting this drug.
References
- Ismo [package insert]. Reddy; 2007.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 1579