What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Ismo (Isosorbide Mononitrate)
Prescription Required
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Product Details
Description
Ismo can be prescribed to treat angina. Angina is a heart condition where blood flow to the heart is reduced, usually by blockages in blood vessels. Common symptoms include shortness of breath, weakness, tiredness, and pressing pain in the chest.
Fact Table
Formula
C6H9NO6
License
US FDA
Bioavailability
More than 95%
Legal status
Rx-only
Chemical Name
Isosorbide mononitrate
Elimination half-life
5 hours
Dosage (Strength)
20mg
Pregnancy
Not Recommended
Brands
Monoket, Imdur
Protein binding
Less than 5%
PubChem CID
27661
MedlinePlus
a682348
ChEBI
6062
ATC code
C01DA14
DrugBank
DB01020
KEGG
D00630
Routes of administration
By mouth
Directions
The usual dosage is 20 mg by mouth twice daily. It should be taken seven hours apart, once upon waking and once again seven hours later. It is critical not to take this medication around the clock (every 12 hours) because this will cause tolerance to build and decrease Ismo's effectiveness.
Ingredients
The active ingredient in Ismo is Isosorbide Mononitrate.
Isosorbide is an organic nitrate medication. It works by converting into nitric oxide in the bloodstream, which relaxes the smooth muscle of the blood vessels, causing them to relax. Relaxing the blood vessels increases blood flow and oxygen delivery.
Interactions
The most common drug-drug interactions with Ismo include:
- Alcohol
- Dapoxetine
- Dapsone (Topical)
- Local Anesthetics
- Molsidomine
- Nitric Oxide
- Prilocaine
- Riociguat
- Sildenafil
- Sodium Nitrite
- Tadalafil
- Vardenafil
Tell your doctor and pharmacist if you are taking any of the above medications before starting Ismo.Cautions
Ismo can cause dizziness and drowsiness. Do not drive or operate machinery until you know how it makes you feel.
Monitor your heart rate and blood pressure while starting this drug.
Use caution if you have a history of traumatic brain injury or intracranial hemorrhage (brain bleed).
Side Effects
The following is a list of potential Ismo side effects:
- Chest pain
- Constipation
- Diarrhea
- Dizziness
- Dry mouth
- Fainting
- Flushing
- Headache
- Irregular heartbeat
- Lightheadedness
- Orthostatic hypotension
- Pain in joints
- Shortness of Breath
- Skin warmth
Tell your doctor and pharmacist about any side effects you experience while starting this drug.References
- Ismo [package insert]. Reddy; 2007.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1579
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