Description
If you have experienced high iron in your blood then you may have received a blood transfusion. After receiving the infusion of red blood cells, your healthcare team may prescribe you to buy Jadenu. Jadenu should only be prescribed by healthcare providers specially trained in the management of chelating agents.
Symptoms of iron overload may include:
- Abnormal heart rhythm
- Darkening of the skin
- Fatigue
- Joint pain
- Stomach pain
Iron overload is also called hemochromatosis and is a chronic condition. If left untreated, it can damage several organs.
Fact Table |
Formula |
C21H15N3O4 |
License |
EU EMA, US FDA |
Bioavailability |
70% |
Legal status |
Rx Only |
Chemical Name |
Deferasirox |
Elimination half-life |
8 to 16 hours
|
Dosage (Strength) |
90mg, 180mg, 360mg |
Pregnancy |
No known Risks |
Brands |
Exjade, Jadenu |
Protein binding |
99% |
PubChem CID |
214348 |
MedlinePlus |
a606002 |
ChEBI |
49005 |
ATC code |
V03AC03 |
DrugBank |
DB01609 |
KEGG |
D03669
|
Routes of administration |
By mouth
|
Directions
Take Jadenu exactly as prescribed by your doctor. Do not change the dose without speaking with them first. Your dose may be adjusted every 3-6 months based on lab readings of blood iron content.
Ingredients
The active ingredient in Jadenu is deferasirox, which is an iron-chelating agent.
Interactions
Tell your doctor and pharmacist about all medications you are taking before you buy Jadenu and begin on this medication. It has many potential drug interactions, including:
- Aluminum Hydroxide
- Amodiaquine
- Alosetron
- Bendamustine
- Bile Acid Sequestrants
- Busulfan
- Fosphenytoin
- Phenytoin
- Phenobarbital
- Rasagiline
- Ritonavir
- Rifampin
- Selexipag
- Theophylline
- Tizanidine
Do not start any over-the-counter medications (OTC), herbals, or supplements while on Jadenu without first speaking with your healthcare team.
Cautions
Tell your doctor if you have a history of ear or ear disorders since Jadenu can worsen these problems.
Use caution if you have a history of kidney or liver problems. These effects may happen more frequently in older adults.
Stop using Jadenu immediately if a skin rash develops or if you experience breathing difficulties.
Your doctor should monitor your blood cells while taking this drug.
Side Effects
Common Jadenu side effects may include:
- Abdominal pain
- Acute pancreatitis
- Anxiety
- Cholelithiasis
- Diarrhea
- Dizziness
- Duodenal ulcer
- Dyschromia
- Edema
- Fanconi's Syndrome
- Fatigue
- Gastrointestinal hemorrhage
- Gastritis
- Increased liver enzymes
- Nausea
- Proteinuria
- Serum creatinine increase
- Skin rash
- Sleep disorder
- Vomiting
References
Jadenu [package insert]. East Hanover, NJ: Novartis; 2020.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13225