What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Jadenu (Deferasirox)
Prescription Required
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Product Details
Description
If you have experienced high iron in your blood then you may have received a blood transfusion. After receiving the infusion of red blood cells, your healthcare team may prescribe you to buy Jadenu. Jadenu should only be prescribed by healthcare providers specially trained in the management of chelating agents.
Symptoms of iron overload may include:
- Abnormal heart rhythm
- Darkening of the skin
- Fatigue
- Joint pain
- Stomach pain
Iron overload is also called hemochromatosis and is a chronic condition. If left untreated, it can damage several organs.Fact Table
Formula
C21H15N3O4
License
EU EMA, US FDA
Bioavailability
70%
Legal status
Rx Only
Chemical Name
Deferasirox
Elimination half-life
8 to 16 hours
Dosage (Strength)
90mg, 180mg, 360mg
Pregnancy
No known Risks
Brands
Exjade, Jadenu
Protein binding
99%
PubChem CID
214348
MedlinePlus
a606002
ChEBI
49005
ATC code
V03AC03
DrugBank
DB01609
KEGG
D03669
Routes of administration
By mouth
Directions
Take Jadenu exactly as prescribed by your doctor. Do not change the dose without speaking with them first. Your dose may be adjusted every 3-6 months based on lab readings of blood iron content.
Ingredients
The active ingredient in Jadenu is deferasirox, which is an iron-chelating agent.
Interactions
Tell your doctor and pharmacist about all medications you are taking before you buy Jadenu and begin on this medication. It has many potential drug interactions, including:
- Aluminum Hydroxide
- Amodiaquine
- Alosetron
- Bendamustine
- Bile Acid Sequestrants
- Busulfan
- Fosphenytoin
- Phenytoin
- Phenobarbital
- Rasagiline
- Ritonavir
- Rifampin
- Selexipag
- Theophylline
- Tizanidine
Do not start any over-the-counter medications (OTC), herbals, or supplements while on Jadenu without first speaking with your healthcare team.Cautions
Tell your doctor if you have a history of ear or ear disorders since Jadenu can worsen these problems.
Use caution if you have a history of kidney or liver problems. These effects may happen more frequently in older adults.
Stop using Jadenu immediately if a skin rash develops or if you experience breathing difficulties.
Your doctor should monitor your blood cells while taking this drug.
Side Effects
Common Jadenu side effects may include:
- Abdominal pain
- Acute pancreatitis
- Anxiety
- Cholelithiasis
- Diarrhea
- Dizziness
- Duodenal ulcer
- Dyschromia
- Edema
- Fanconi's Syndrome
- Fatigue
- Gastrointestinal hemorrhage
- Gastritis
- Increased liver enzymes
- Nausea
- Proteinuria
- Serum creatinine increase
- Skin rash
- Sleep disorder
- Vomiting
References
Jadenu [package insert]. East Hanover, NJ: Novartis; 2020.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13225
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