What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Janumet (Sitagliptin / Metformin)
Prescription Required
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Product Details
Description
What is janumet used for?
Janumet (Sitagliptin/Metformin)
Janumet medication is used to control high blood sugar. This drug is used with a proper diet and exercise plan and mostly by patients with type 2 diabetes.
This medicine contains sitagliptin metformin. Sitagliptin works by increasing the substance called incretins that is naturally present in our body. Incretins help in controlling the level of blood sugar by increasing the release of insulin right after a meal.
Incretins also help to decrease the amount of sugar made by the liver. Metformin helps in restoring the body's proper response to the insulin you produce naturally. It also decreases the amount of sugar made in the liver and absorbed in the stomach and intestines.
Controlling the high blood sugar level prevents the kidney from being damaged, nerve problems, blindness and sexual function problems.
Fact Table
Formula
Sitagliptin: C16H15F6N5O; Metformin: C4H11N5
License
FDA approved
Bioavailability
Sitagliptin: ~87%; Metformin: 50-60%
Legal status
Prescription medicine
Chemical Name
Sitagliptin/Metformin
Elimination half-life
Sitagliptin: ~12.4 hours; Metformin: ~6.2 hours
Dosage (Strength)
Available in combinations of 50mg Sitagliptin/500mg Metformin, 50mg Sitagliptin/1000mg Metformin, and others
Pregnancy advice
Use only if clearly needed and the potential benefits outweigh the risks. Consult a healthcare provider.
Brands
Janumet
Protein binding
Sitagliptin: 38%; Metformin: Not significant
PubChem CID
Sitagliptin: 4369359; Metformin: 4091
MedlinePlus
a606023
ChEBI
Sitagliptin: CHEBI:40237; Metformin: CHEBI:6801
ATC code
A10BD07
DrugBank
Sitagliptin: DB01261; Metformin: DB00331
KEGG
Sitagliptin: D08514; Metformin: D04966
Routes of administration
Oral
Directions
Janumet medication is to be taken orally. It is normally administered twice a day. You must drink plenty of water with this drug unless otherwise directed by your physician. The manufacturer advises not to split tor cut the tablet; however, follow your doctor's direction on how to take this medicine.
The dosage of Janumet medication depends on the severity of your medical condition and how you respond to the treatment. Make sure to take the medicine regularly or as advised by your physician and take it at the same time every day.Ingredients
Ingredients in Janumet include:
- Povidone
- Hypromellose
- Colloidal silicon dioxide
- Sodium stearyl fumarate
- Propyl gallate
- Polyethylene glycol
- Kaolin
Cautions
- Let your physician know about the medical treatments and medicines you are using.
- This medication might increase your blood pressure so check your blood pressure regularly.
- Let your doctor know if you have any allergies before using it.
- Before using this medicine, let your doctor know if you are allergic to sitagliptin metformin.
Side Effects
Some common side effects that you may experience with Janumet medication are:
- Diarrhoea
- Gas
- Headache
- Indigestion
- Nausea
- Sore throat
- Stomach pain
- Upset stomach
- Stuffy or runny nose
- Vomiting
- Weakness
- Chest pain or discomfort
- Dizziness
- Lightheadedness
- Fast or difficult breathing
- Fever
- Chills
- Sore throat
- Feeling of being unusually cold
- General feeling of being unwell
- Muscle pain or weakness
- Slow or irregular heartbeat
- Swelling of your hands, legs, face, lips, eyes, throat, or tongue
- Difficulty swallowing or breathing
- Unusual hoarseness
- Unusual or persistent stomach pain or discomfort
- Unusual drowsiness
- Unusual tiredness or weakness
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10065
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