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Januvia (Sitagliptin Phosphate)
(Known as Istavel in the UK)
How Does Januvia Work
JANUVIA belongs to a new breakthrough class of prescription medications called dipeptidyl peptidase-4 (DPP-4) inhibitors that improves blood sugar control in patients with type 2 diabetes. JANUVIA enhances a natural body system called the incretin system, which helps to regulate glucose by affecting the beta cells and alpha cells in the pancreas. Through DPP-4 inhibition, JANUVIA works only when blood sugar is elevated to address diminished insulin due to beta-cell dysfunction and uncontrolled production of glucose by the liver due to alpha-cell and beta-cell dysfunction.
JANUVIA is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medication regularly to get the most benefit.JANUVIA is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medication regularly to get the most benefit.
Take JANUVIA as exactly as prescribed by your doctor. Your doctor may occasionally change your dose to make sure you get the best results. Patients can take JANUVIA with or without food.
Ask your doctor how to adjust your JANUVIA dose if needed. Do not change your medication dose or schedule without your doctor's advice.
JANUVIA is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. Before taking JANUVIA, tell your doctor if you have:
- kidney disease
- are on dialysis
- have a history of pancreatitis
- are pregnant or planning on becoming pregnant
- breastfeeding a newborn
- are allergic to JANUVIA
- are in a state of diabetic ketoacidosis
JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA.
Talk with your doctor about additional risks and benefits of using JANUVIA.
Serious side effects can occur in patients taking JANUVIA, including inflammation of the pancreas (pancreatitis) which may be severe and lead to death or serious allergic reactions. Contact your doctor immediately.
The most common side effects of JANUVIA include:
- upper respiratory infection
- stuffy or runny nose and sore throat
- stomach upset and diarrhea
- swelling of the hands or legs, when JANUVIA is used with the combination of metformin & rosiglitazone (other types of diabetes medicines)
- elevated liver enzymes
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about additional side effects or any side effect that bothers you or that do not go away.
Product Code: 9461
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.