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Kazano (Alogliptin/Metformin)
(Known as Nesina Met in the UK)
Prescription Required
Ingredients:
Indication for NESINA (alogliptin) 6.25 mg, 12.5 mg, and 25 mg Tablets; OSENI (alogliptin and pioglitazone) 25 mg/15 mg, 25 mg/30 mg, 25 mg/45 mg, 12.5 mg/15 mg, 12.5 mg/30 mg, and 12.5 mg/45 mg Tablets; and KAZANO (alogliptin and metformin HCl) 12.5 mg/500 mg and 12.5 mg/1000 mg Tablets
Cautions:
WARNING for OSENI (alogliptin and pioglitazone): RISK OF HEART FAILURE OSENI can cause heart failure and cause your body to keep extra fluid (fluid retention), which leads to swelling (edema) and weight gain. Extra body fluid can make some heart problems worse or lead to heart failure. Before you start taking OSENI, tell your doctor if you have ever had heart failure or have problems with your kidneys. Call your doctor right away if you experience shortness of breath or trouble breathing (especially when you lie down), an unusually fast increase in weight or swelling or fluid retention (especially in the feet, ankles or legs). These may be symptoms of heart failure. WARNING for KAZANO (alogliptin and metformin HCl): RISK OF LACTIC ACIDOSIS Metformin, one of the medicines in KAZANO, can cause a rare but serious condition called lactic acidosis (a buildup of an acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital. Stop taking KAZANO and call your doctor right away if you feel very weak or tired, have unusual (not normal) muscle pain, have trouble breathing, feel sleepy or drowsy, have stomach pains, nausea or vomiting, feel cold in your hands or feet, feel dizzy or lightheaded, or have a slow or irregular heartbeat, as these could be symptoms of lactic acidosis. You have a higher chance of getting lactic acidosis if you have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye, have liver problems, have congestive heart failure that requires treatment with medicines, drink a lot of alcohol (very often or short-term “binge” drinking), get dehydrated (lose a large amount of body fluids, which can happen if you are sick with a fever, vomiting, or diarrhea, or when you sweat a lot with activity or exercise and do not drink enough fluids), have surgery, have a heart attack, severe infection, or stroke. The best way to keep from having a problem with lactic acidosis from metformin is to tell your doctor if you have any of the problems listed above. Your doctor may decide to stop KAZANO for a while if you have any of these things.
Side Effects:
Side Effects The most common side effects of NESINA were stuffy or runny nose and sore throat (4.8%), cold-like symptoms (upper respiratory tract infection; 4.5%), and headache (4.3%). The most common side effects of KAZANO were cold-like symptoms (upper respiratory tract infection) (8.0%), stuffy or runny nose and sore throat (6.8%), diarrhea (5.5%), increase in blood pressure (5.5%), headache (5.3%), back pain (4.3%), and urinary tract infection (4.2%). The most common side effects of OSENI were stuffy or runny nose and sore throat (4.9%), back pain (4.2%), and cold-like symptoms (upper respiratory tract infection; 4.1%).
Product Code: 13227
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
