What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Kerendia (Finerenone)
Prescription Required
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Product Details
Description
Kerendia (finerenone) is used to decrease the risk of worsening of kidney failure, kidney disease, cardiovascular death, heart attack, and heart failure hospitalization in adults who have chronic kidney disease and type 2 diabetes.
Fact Table
Formula
C21H22N4O3
License
US DailyMed
Bioavailability
43.5%
Legal status
Rx-Only
Chemical Name
Finerenone
Elimination half-life
17.4 hours
Dosage (Strength)
10mg, 20mg
Pregnancy
Consult Doctor
Brands
Kerendia
Protein binding
92%
PubChem CID
60150535
MedlinePlus
a621038
ChEBI
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ATC code
C03DA05
DrugBank
DB16165
KEGG
D10633
Routes of administration
By mouth
Directions
Kerendia is available in 10 mg and 20 mg oral tablets.
Follow the instructions that come with your Kerendia prescription. If you have any questions or concerns about your prescription, talk to your doctor or pharmacist.
Your starting dose will depend on your kidney function and potassium levels in your blood. The typical starting dosage is to take 10 mg or 20 mg by mouth once daily with or without food. After 4 weeks, your doctor may increase your dose to 20 mg once daily depending on your kidney function and blood potassium levels.
Ingredients
Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, is the active ingredient contained in Kerendia.
Contraindications
Do not take Kerendia with other CYP3A4 inhibitors. Ask your doctor if you are unsure whether or not you are taking other CYP3A4 inhibitors.
Do not take Kerendia if you have a condition in which your adrenal glands do not make enough hormones.
Cautions
- Before you start treatment with Kerendia, it's important to discuss the following with your doctor:
- All the medications you take. These include prescription and over-the-counter medications, as well as vitamins and herbal supplements.
- Your allergies.
- Your health conditions, including liver problems.
- Your pregnancy status.
- Your breastfeeding status. Breastfeeding should be avoided during Kerendia treatment and for one day after treatment.
- Kerendia can cause elevated potassium levels in the blood. Seek emergency care right away if you experience muscle weakness, rapid heartbeats, trouble breathing, chest pain, nausea, or vomiting.
- Do not consume grapefruit or grapefruit juice during treatment with Kerendia.
Side Effects
The most common side effects of Kerendia include elevated potassium levels in the blood, low blood pressure, and low sodium levels in the blood; however, these are not all the possible side effects of Kerendia. Contact your doctor right away if you have side effects that concern you or won't go away.
References:
- Kerendia (finerenone) tablets, for oral use. Whippany, NJ: Bayer HealthCare Pharmaceuticals, Inc.; 2021.
- Kerendia (finerenone) tablets. Important Safety Information. Accessed March 25, 2022.
- Adrenal Insufficiency. Endocrine Society. January 23, 2022. Accessed March 25, 2022.
- What is Hyperkalemia? National Kidney Foundation. Accessed March 25, 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13658
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