What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lampit (Nifurtimox)
Prescription Required
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Product Details
Description
Lampit (nifurtimox) is used to treat Chagas disease (American trypanosomiasis), caused by Trypanosoma cruzi, in patients from birth to less than 18 years old who weigh 2.5 kg or more.
Fact Table
Formula
C10H13N3O5S
License
US DailyMed
Bioavailability
Low
Legal status
Rx-only
Chemical Name
Nifurtimox
Elimination half-life
2.95 ± 1.19 hours
Dosage (Strength)
30mg, 60mg
Pregnancy
Not recommended
Brands
Vermox
Protein binding
42%
PubChem CID
6842999
MedlinePlus
a620061
ChEBI
7566
ATC code
P01CC01
DrugBank
DB11820
KEGG
D00833
Routes of administration
By mouth
Directions
The instructions on the prescription should be followed. Talk to your doctor or pharmacist about any questions or concerns you may have.
Lampit is available in 30 mg and 120 mg tablets that are scored.
Dosing:
Patients who weigh at least 41 kg: 8-10 mg/kg total per day.
Patients who weigh less than 41 kg: 10 to 20 mg/kg total per day.
Lampit should be taken by mouth three times a day with food for 60 days.
A pregnancy test should be taken in women who are of childbearing age before starting treatment with Lampit.
Ingredients
The active ingredient in Lampit is nifurtimox, a nitrofuran antiprotozoal.
Contraindications
Lampit should not be taken in patients who are allergic to nifurtimox or any of its other ingredients or excipients.
Patients should not consume alcohol during treatment with Lampit.
Cautions
- Before starting treatment with Lampit, patients should tell their doctor:
- About all the medications they take, including prescription and over-the-counter, vitamins, and herbal supplements
- About their allergies
- About their health conditions
- If they are pregnant or plan to become pregnant
- If they are breastfeeding or plan to breastfeed
- Genotoxicity and carcinogenicity may potentially occur with the use of Lampit.
- Lampit may cause harm to an unborn baby. A pregnancy test should be taken in women of childbearing age before starting treatment with Lampit. Birth control methods should be used. Males should use condoms.
- Lampit may worsen neurological and psychiatric conditions, especially in patients who have or have had a brain injury, seizures, psychiatric disease, and serious behavioral changes.
- Lampit may cause severe allergic reactions such as low blood pressure, swelling under the skin, shortness of breath, itching, rash, or other skin reactions. Patients should seek medical care right away if any of these occur.
- Lampit may cause a decrease in appetite and weight. Patients should monitor their weight every 2 weeks. The dose may be adjusted based on weight.
- Lampit may cause porphyria, which is an excess of chemicals in the body that make porphyrin.
Side Effects
The side effects caused by Lampit include, but are not limited to, stomach pain, nausea, vomiting, headache, decreased appetite, fever, and rash. Call your doctor right away if you develop side effects that bother you or won't go away.
References:
- Lampit (nifurtimox) tablets, for oral use. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc.; 2020.
- Porphyria. Mayo Clinic. June 3, 2020. Accessed March 22, 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13653
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