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Leukeran (Chlorambucil)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details

    Description

    Leukeran (chlorambucil) is prescribed to treat certain types of cancers, including chronic lymphocytic leukemia and Hodgkin’s lymphoma. It works by slowing down or stopping cancer cell growth.

    Leukeran is available in 2 mg oral tablets.

    Fact Table

    Formula

    C14H19Cl2NO2

    License

    US FDA, EMA

    Bioavailability

    70-100% (oral)

    Legal status

    Prescription only (Rx)

    Chemical Name

    Chlorambucil

    Elimination half-life

    1.5 hours

    Dosage (Strength)

    2 mg tablets

    Pregnancy

    Contraindicated

    Brands

    Leukeran

    Protein binding

    >99%

    PubChem CID

    2708

    MedlinePlus

    a682899

    ChEBI

    CHEBI:28915

    ATC code

    L01AA02

    DrugBank

    DB00577

    KEGG

    D07500

    Routes of administration

    Oral

    Directions

    Take Leukeran exactly as prescribed by your doctor. For additional instructions for use, read the medication guide that accompanies your prescription.

    Your doctor will determine an appropriate treatment regimen for you based on the condition being treated, your weight, and your response to the medication. Leukeran is generally taken by mouth once daily.

    Keep Leukeran stored in the refrigerator and avoid freezing. Keep the medication away from children and pets.

    If you have any questions or concerns about Leukeran, talk to your doctor or pharmacist.

    Ingredients

    The active ingredient in Leukeran is chlorambucil.

    Contraindications

    Patients with an allergy or resistance to Leukeran medication should not take it.

    Cautions

    • Leukeran contains the following FDA Boxed Warning:
      • Severe suppression of the bone marrow may occur.
      • Long-term therapy with Leukeran may cause myelocytic leukemia and secondary cancers.
      • Infertility and fetal abnormalities can occur with Leukeran.
    • Before you begin treatment with Leukeran, tell your doctor about:
      • All the prescription and over-the-counter medications you take
      • Your allergies
      • Your current health problems and past medical history
      • Your pregnancy or breastfeeding status
    • Leukeran is associated with the following cautions:
      • Seizure history, head trauma, or those taking medications that can cause epilepsy
      • Potentially cancer-causing
      • Potentially harmful to an unborn baby; Leukeran should not be taken while pregnant. Effective birth control methods should be used while receiving Leukeran
      • Infertility can occur
      • Severe bone marrow suppression can occur
      • Lower doses may be required in patients with liver failure or preexisting situations of bone marrow suppression or if white blood cell counts or platelets drop below normal
      • If taken within 4 weeks of radiation or chemotherapy
      • Be cautious of cross-hypersensitivity with other medications that are in the same drug class as Leukeran

    Side Effects

    Low blood cell counts, seizures, nausea, and vomiting are possible Leukeran side effects; however, other side effects may also occur. Immediately tell your doctor if you have side effects that bother you or won’t go away.

    Looking for a competitive Leukeran 2 mg price? You can buy Leukeran tablets right here.

    References

    1. Leukeran. Medscape.
    2. Leukeran. New Zealand: Pharmacy Retailing Pty Ltd; 2012.


    Dr Savannah Muncy
    About Dr. Savannah Muncy (Page Author)


    Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 2445

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