Description
LEXIVA is a prescription medication used to treat HIV infection. Left untreated, HIV infection can lead to acquired immunodeficiency syndrome (AIDS).
HIV is a long-term infection that weakens the immune system and leaves a person susceptible to opportunistic infections.
LEXIVA is an antiviral HIV protease inhibitor. It works by shutting down a protein critical for HIV virus replication. LEXIVA slows down replication and prevents infections from worsening.
Directions
LEXIVA must be taken every day exactly as prescribed by the doctor.
It can be taken with or without food.
Your doctor will determine the best LEXIVA dosage. Some example regimens include:
- Hepatic impairment: Adjusted based on directions from the prescriber
- Treatment-naive: LEXIVA 1400 mg by mouth twice daily plus ritonavir
- Pediatric (2 to 18 years old): Calculate based on body weight
Protease Inhibitor-experienced adults: LEXIVA 700 mg twice daily plus ritonavir 100 mg twice daily
Ingredients
The active ingredient in LEXIVA is fosamprenavir.
Fact Table |
Formula |
C25H36N3O9PS |
License |
AU, EU EMA |
Bioavailability |
- |
Legal status |
RX Only |
Chemical Name |
Fosamprenavir |
Elimination half-life |
7.7 hours |
Dosage (Strength) |
700mg (60 tablets) |
Pregnancy |
Consult a doctor |
Brands |
Lexiva, Telzir |
Protein binding |
90% |
PubChem CID |
131536 |
MedlinePlus |
a604012 |
ChEBI |
82941 |
ATC code |
J05AE07 |
DrugBank |
DB01319 |
KEGG |
D02497 |
Routes of administration |
Oral |
Interactions
LEXIVA is contraindicated when the following medications:
- Cisapride
- Delavirdine
- Dihydroergotamine
- Ergonovine
- Ergotamine
- Flecainide
- Lovastatin
- Methylergonovine
- Midazolam
- Pimozide
- Propafenone
- Rifampin
- Simvastatin
- St. John's Wort
- Triazolam
Use caution if you are taking any of the following medications. Tell your doctor and pharmacist your full list of drugs before you start taking LEXIVA. Common drug interactions include:
- Alprazolam
- Amiodarone
- Atazanavir
- Atorvastatin
- Bepridil
- Calcium Channel Blockers
- Carbamazepine
- Clorazepate
- Cyclosporine
- Dexamethasone
- Diazepam
- Efavirenz
- Flurazepam
- Fluticasone
- H2 receptor antagonists
- Indinavir
- Itraconazole
- Ketoconazole
- Lidocaine
- Lopinavir/ritonavir
- Methadone
- Nelfinavir
- Nevirapine
- Oral contraceptives
- Paroxetine
- PDE5 Inhibitors
- Phenobarbital
- Phenytoin
- Proton pump inhibitors
- Quinidine
- Rapamycin
- Rifabutin
- Rosuvastatin
- Saquinavir
- Tacrolimus
- Trazodone
- Tricyclic antidepressants
- Warfarin
Cautions
Tell your doctor if you have a history of nephrolithiasis, diabetes, anemia, hemophilia, high cholesterol, hepatitis B or C, or a sulfonamide allergy.
LEXIVA may cause fat redistribution and immune reconstitution syndrome.
If a skin reaction happens while taking LEXIVA, stop taking the drug, and call your doctor's office.
Side Effects
Adverse reactions from LEXIVA may include:
- Diarrhea
- Headache
- Nausea
- Rash
- Vomiting
For a full list of side effects, speak with your pharmacist.
References
Lexiva [package insert]. Research Triangle Park, NJ: GlaxoSmithKline; 2009.
Product Code : 12590