What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Linzess (Linaclotide)

Also Known as Constella

Sezzle
Brand

Linzess (Linaclotide)

Prescription Required

Strength
Qty
72mcg
145mcg
290mcg

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  • Product Details

    Description

    LINZESS (Linaclotide) is a medication prescribed to either irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC). Patients with IBS-C and CIC have chronic symptoms of constipation and reduced passage of stool.

    LINZESS works by attaching to guanylate cyclase-C (GC-C) on the surface of intestinal epithelium cells. The activation of GC-C receptors increases the compound cyclic guanosine monophosphate, which causes intestinal cells to excrete chloride and bicarbonate and pull fluid into the intestinal space. LINZESS may also help to stop muscle contractions of the abdomen that cause pain.

    How long does it take LINZESS to work? Most patients have maximum relief of constipation by the second week of treatment.

    Directions

    Your doctor will prescribe a LINZESS dosage based on which condition is being treated. The usual dosages are:

    • IBC-C: 290 micrograms (mcg) by mouth once daily
    • CIC: 72 to 145 mcg by mouth once daily

    Take LINZESS on an empty stomach at least 30 minutes before the first meal of the day. Do not crush, chew, or open LINZESS capsules; swallow whole.

    Ingredients

    The active ingredient in LINZESS is linaclotide.


    Fact Table

    Formula

    C18H24O2

    License

    EU EMA, US FDA

    Bioavailability

    0.1%

    Legal status

    RX Only

    Chemical Name

    Linaclotide

    Elimination half-life

    13-20 hours

    Dosage (Strength)

    72mcg (30 or 90 capsules), 145mcg (30 or 90 capsules), 290mcg (28 or 84 capsules)

    Pregnancy

    Consult a doctor

    Brands

    Linzess

    Protein binding

    -

    PubChem CID

    16158208

    MedlinePlus

    a613007

    ChEBI

    68551

    ATC code

    A06AX04

    DrugBank

    DB08890

    KEGG

    D09355

    Routes of administration

    By mouth

    Cautions

    The most common side effect while taking LINZESS is diarrhea, which can be severe in some patients. Patients with diarrhea have a high risk of dehydration while taking LINZESS. Symptoms of dehydration may include fainting, dizziness, low blood pressure, and electrolyte abnormalities.

    If you overdose and experience serious side effects and symptoms call your nearest doctor or pharmacist as soon as possible, it may have serious effects on your body. Keep these capsules at room temperature and away from moisture and heat.

    Side Effects

    Some of the most common adverse reactions from LINZESS may include:

    • Abdominal Distension
    • Abdominal Pain
    • Diarrhea
    • Flatulence
    • Headache
    • Viral Gastroenteritis

    If you experience severe diarrhea while taking LINZESS, tell your doctor. You may need to pause taking the medication. Ensure that you are hydrating during any and all episodes of diarrhea.

    References

    1. Linzess [package insert]. Irvine, CA: Allergan; 2017.


    Dr Conor Sheehy
    About Dr. Conor Sheehy (Page Author)

    Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13163

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