Linzess is a guanylate cyclase C agonist indicated in adults for the treatment of Irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC).
IBS-C - Take 290mcg orally once daily. CIC - Take 145mcg orally once daily. Take on a empty stomach, at least 30 minutes prior to the first meal of the day.
For elderly patients, although no dose adjustment is required the treatment should be carefully monitored and periodically re-assessed Linzess is contraindicated for patients with known or suspected mechanical gastrointestinal obstruction. Should prolonged (e.g. more than 1 week) or severe diarrhoea occur, medical advice should be sought and temporary discontinuation of linaclotide until diarrhoea episode is resolved may be considered.
Diarrhoea, mainly mild to moderate in intensity, occurring in less than 20% of patients. This may – as a consequence – lead to the occurrence of dehydration, hypokalaemia, blood bicarbonate decrease, dizziness, and orthostatic hypotension. Other common adverse reactions (>1%) were abdominal pain, abdominal distension and flatulence, rash.
Product Code: 13163
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