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Linzess (Linaclotide)
Also Known as Constella
Prescription Required
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Product Details
Description
LINZESS (Linaclotide) is a medication prescribed to either irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC). Patients with IBS-C and CIC have chronic symptoms of constipation and reduced passage of stool.
LINZESS works by attaching to guanylate cyclase-C (GC-C) on the surface of intestinal epithelium cells. The activation of GC-C receptors increases the compound cyclic guanosine monophosphate, which causes intestinal cells to excrete chloride and bicarbonate and pull fluid into the intestinal space. LINZESS may also help to stop muscle contractions of the abdomen that cause pain.
How long does it take LINZESS to work? Most patients have maximum relief of constipation by the second week of treatment.
Directions
Your doctor will prescribe a LINZESS dosage based on which condition is being treated. The usual dosages are:
- IBC-C: 290 micrograms (mcg) by mouth once daily
- CIC: 72 to 145 mcg by mouth once daily
Take LINZESS on an empty stomach at least 30 minutes before the first meal of the day. Do not crush, chew, or open LINZESS capsules; swallow whole.
Ingredients
The active ingredient in LINZESS is linaclotide.
Fact Table
Formula
C18H24O2
License
EU EMA, US FDA
Bioavailability
0.1%
Legal status
RX Only
Chemical Name
Linaclotide
Elimination half-life
13-20 hours
Dosage (Strength)
72mcg (30 or 90 capsules), 145mcg (30 or 90 capsules), 290mcg (28 or 84 capsules)
Pregnancy
Consult a doctor
Brands
Linzess
Protein binding
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PubChem CID
16158208
MedlinePlus
a613007
ChEBI
68551
ATC code
A06AX04
DrugBank
DB08890
KEGG
D09355
Routes of administration
By mouth
Cautions
The most common side effect while taking LINZESS is diarrhea, which can be severe in some patients. Patients with diarrhea have a high risk of dehydration while taking LINZESS. Symptoms of dehydration may include fainting, dizziness, low blood pressure, and electrolyte abnormalities.
If you overdose and experience serious side effects and symptoms call your nearest doctor or pharmacist as soon as possible, it may have serious effects on your body. Keep these capsules at room temperature and away from moisture and heat.Side Effects
Some of the most common adverse reactions from LINZESS may include:
- Abdominal Distension
- Abdominal Pain
- Diarrhea
- Flatulence
- Headache
- Viral Gastroenteritis
If you experience severe diarrhea while taking LINZESS, tell your doctor. You may need to pause taking the medication. Ensure that you are hydrating during any and all episodes of diarrhea.
References
- Linzess [package insert]. Irvine, CA: Allergan; 2017.
Frequently Asked Questions about Linzess (Linaclotide)
What does Linzess do?
Linzess is a prescription medication for adults with IBS-C (Irritable Bowel Syndrome with Constipation) and CIC (Chronic Idiopathic Constipation), and for children aged 6-17 years with FC (Functional Constipation). It contains linaclotide, which stimulates intestinal receptors to soften stools and induce bowel movements.
How to take Linzess?
Take Linzess in the morning on an empty stomach, at least 30 minutes before your first meal. Swallow the capsule whole and do not crush, chew, break, or open it.
How long does it take for Linzess to kick in?
The onset of action for Linzess varies, but some people may experience relief within a few days to a week of starting treatment.
What to avoid when taking Linzess?
Avoid using Linzess if you have a blockage in your intestines. Additionally, do not crush, chew, break, or open the capsule; swallow it whole.
Do you have a bowel movement every day with Linzess?
Linzess helps relieve constipation, but individual responses may vary. Regular bowel movements can occur, but it’s essential to follow your doctor’s guidance.
Why can't you take Linzess at night?
Taking Linzess in the morning on an empty stomach ensures optimal absorption and effectiveness. Nighttime dosing may interfere with this process.
What is the most common side effect of Linzess?
The most common side effect of Linzess is diarrhea. If severe or ongoing diarrhea occurs, contact your doctor promptly.
How long can you stay on Linzess?
The duration of Linzess treatment depends on your specific condition and your doctor’s recommendation. Regular follow-up with your healthcare provider is essential.
Does Linzess cause weight gain?
Weight gain is not a common side effect associated with Linzess.
Can you drink alcohol with Linzess?
There are no specific alcohol restrictions with Linzess, but it’s always best to consult your doctor regarding any potential interactions.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13163
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