What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lozol (Indapamide)
Prescription Required
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Product Details
Description
LOZOL (Indapamide) is a prescription medication that can treat edema (swelling caused by fluid buildup) and hypertension (high blood pressure). LOZOL belongs to the thiazide-diuretic class of medications.
LOZOL works by causing the kidneys to release extra water and electrolytes into the urine. LOZOL blocks the passage of sodium ions, so sodium cannot re-enter the bloodstream. Chloride ions and water molecules follow the excreted sodium.
LOZOL treats edema and hypertension by reducing the amount of fluid in the bloodstream.
Directions
For edema, the starting dose is LOZOL 2.5 mg by mouth once daily. The dose may be increased to a maximum of 5 mg once daily.
For hypertension, the starting dose is LOZOL 1.25 mg by mouth once daily. The maximum dose is 5 mg once daily.
Ingredients
The active ingredient in LOZOL is indapamide.
Fact Table
Formula
C16H16ClN3O3S
License
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Bioavailability
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Legal status
RX Only
Chemical Name
Indapamide
Elimination half-life
14-18 hours
Dosage (Strength)
1.25mg (100 tablets), 2.5mg (100 tablets)
Pregnancy
Consult a doctor
Brands
Lozol
Protein binding
71-79%
PubChem CID
3702
MedlinePlus
a684062
ChEBI
5893
ATC code
C03BA11
DrugBank
DB00808
KEGG
D00345
Routes of administration
By mouth (tablets)
Interactions
Tell your healthcare provider if you are taking any of the following medications:
- Amifostine
- Antihypertensive medications
- Bile acid sequestrants
- Dofetilide
- Lithium
- Loop diuretics
- Obinutuzumab
- Sodium phosphates
- Thiazide diuretics
- Topiramate
Cautions
LOZOL may cause photosensitivity (sensitivity to the sun). Use additional skin protection, like sunscreen, while taking LOZOL.
Do not use this medication if you have a documented history of sulfonamide ("sulfa") allergy.
Your healthcare provider should monitor your electrolyte levels while you are taking LOZOL. Hypokalemia (low potassium levels) have been reported, especially in older patients. There is also a risk that other electrolyte levels may decrease while taking LOZOL.
Side Effects
The most common (>5% of people) may include:
- Agitation
- Anxiety
- Back pain
- Dizziness
- Fatigue
- Headache
- Hypokalemia
- Infection
- Irritability
- Lethargy
- Malaise
- Muscle cramps
- Muscle spasm
- Nervousness
- Pain
- Paresthesia
- Rhinitis
- Tension
- Weakness
References
- Lozol [package insert].Bridgewater, NJ: Aventis; 2005.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13267
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