Description
LOZOL (Indapamide) is a prescription medication that can treat edema (swelling caused by fluid buildup) and hypertension (high blood pressure). LOZOL belongs to the thiazide-diuretic class of medications.
LOZOL works by causing the kidneys to release extra water and electrolytes into the urine. LOZOL blocks the passage of sodium ions, so sodium cannot re-enter the bloodstream. Chloride ions and water molecules follow the excreted sodium.
LOZOL treats edema and hypertension by reducing the amount of fluid in the bloodstream.
Directions
For edema, the starting dose is LOZOL 2.5 mg by mouth once daily. The dose may be increased to a maximum of 5 mg once daily.
For hypertension, the starting dose is LOZOL 1.25 mg by mouth once daily. The maximum dose is 5 mg once daily.
Ingredients
The active ingredient in LOZOL is indapamide.
Fact Table |
Formula |
C16H16ClN3O3S |
License |
- |
Bioavailability |
- |
Legal status |
RX Only |
Chemical Name |
Indapamide |
Elimination half-life |
14-18 hours |
Dosage (Strength) |
1.25mg (100 tablets), 2.5mg (100 tablets) |
Pregnancy |
Consult a doctor |
Brands |
Lozol |
Protein binding |
71-79% |
PubChem CID |
3702 |
MedlinePlus |
a684062 |
ChEBI |
5893 |
ATC code |
C03BA11 |
DrugBank |
DB00808 |
KEGG |
D00345 |
Routes of administration |
By mouth (tablets) |
Interactions
Tell your healthcare provider if you are taking any of the following medications:
- Amifostine
- Antihypertensive medications
- Bile acid sequestrants
- Dofetilide
- Lithium
- Loop diuretics
- Obinutuzumab
- Sodium phosphates
- Thiazide diuretics
- Topiramate
Cautions
LOZOL may cause photosensitivity (sensitivity to the sun). Use additional skin protection, like sunscreen, while taking LOZOL.
Do not use this medication if you have a documented history of sulfonamide ("sulfa") allergy.
Your healthcare provider should monitor your electrolyte levels while you are taking LOZOL. Hypokalemia (low potassium levels) have been reported, especially in older patients. There is also a risk that other electrolyte levels may decrease while taking LOZOL.
Side Effects
The most common (>5% of people) may include:
- Agitation
- Anxiety
- Back pain
- Dizziness
- Fatigue
- Headache
- Hypokalemia
- Infection
- Irritability
- Lethargy
- Malaise
- Muscle cramps
- Muscle spasm
- Nervousness
- Pain
- Paresthesia
- Rhinitis
- Tension
- Weakness
References
- Lozol [package insert].Bridgewater, NJ: Aventis; 2005.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13267