What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Lumakras (Sotorasib)


Lumakras (Sotorasib)

Prescription Required


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  • Product Details


    Lumakras is a prescription medication for treating advanced or metastatic non-small cell lung cancer (NSCLC) with a specific genetic mutation called KRAS G12C. This mutation is present in about 13% of NSCLC cases and has historically been difficult to target with traditional treatments.

    Lumakras works by inhibiting the activity of the mutated KRAS protein, which is a gene responsible for the uncontrolled growth and spread of cancer cells. Lumakras attaches to the protein made by this gene mutation, rendering the protein inactive, which inhibits cancerous cell growth.

    Fact Table




    US DailyMed



    Legal status


    Chemical Name


    Elimination half-life

    5 hours

    Dosage (Strength)



    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth


    The usual dosage is 960 mg by mouth once daily. Lumakras should be taken with or without food.


    The active ingredient is Sotorasib.


    Common drug-drug interactions include:

    • Abemaciclib
    • Antihepaciviral Combination Products
    • Asunaprevir
    • Avacopan
    • Avanafil
    • Avapritinib
    • Axitinib
    • Bedaquiline
    • Elacestrant
    • Elbasvir and Grazoprevir
    • Encorafenib
    • Entrectinib
    • Fedratinib
    • Fexinidazole
    • Finerenone
    • Flibanserin
    • Ganaxolone
    • Lumateperone
    • Lurbinectedin
    • Mavacamten
    • Mobocertinib
    • Neratinib
    • Nirmatrelvir and ritonavir
    • Lovastatin
    • Simeprevir
    • Sonidegib
    • Tazemetostat
    • Topotecan


    Do not use Lumakras if you do not have the KRAS G12C mutation. It is not effective in treating other types of lung cancer.

    Tell your healthcare provider if you have a history of lung or breathing problems before using Lumakras. The medication can cause lung inflammation, which can be serious or life-threatening.

    Your healthcare provider should administer a liver function test every three weeks for the first three months of treatment.

    Side Effects

    Common side effects may include:

    • Edema
    • Skin rash
    • Decreased serum albumin
    • Decreased serum calcium
    • Decreased serum sodium
    • Abdominal pain
    • Decreased appetite
    • Diarrhea
    • Nausea
    • Vomiting
    • Increase in urinary protein
    • Decreased hemoglobin
    • Lymphocytopenia
    • Prolonged partial thromboplastin time
    • Hepatotoxicity
    • Increased serum alanine aminotransferase
    • Increased serum alkaline phosphatase
    • Increased serum aspartate aminotransferase
    • Fatigue
    • Arthralgia
    • Musculoskeletal pain
    • Cough
    • Dyspnea
    • Pneumonia
    • Cardiac failure
    • Gastric ulcer
    • Interstitial pulmonary disease
    • Pneumonitis
    • Respiratory failure


    1. Lumakras [package insert]. Thousand Oaks, CA: Amgen; 2021.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13778

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