What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lynparza (Olaparib)
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Product Details
Description
LYNPARZA (Olaparib) is an oral chemotherapy medication prescribed to treat certain types of ovarian and breast cancers. LYNZPARZA is prescribed and managed by an oncologist.
People with cancer have cells that are replicating more often than they should. The replicating cells push into the surrounding tissue, causing damage and taking nutrients intended for other parts of the body.
LYNZPARZA works by preventing the replication of cancer cells, decreasing tumor growth.
Directions
The usual dose is 300 mg by mouth twice daily. LYNPARZA may be taken with or without food.
Ingredients
The active ingredient in LYNPARZA is olaparib.
Fact Table
Formula
C24H23FN4O3
License
AU, EU EMA, US FDA
Bioavailability
0.5-2 hours
Legal status
RX Only
Chemical Name
Olaparib
Elimination half-life
5-11 hours
Dosage (Strength)
150mg (112 tablets)
Pregnancy
Consult a doctor
Brands
Lynparza
Protein binding
82%
PubChem CID
23725625
MedlinePlus
a614060
ChEBI
83766
ATC code
L01XK01
DrugBank
DB09074
KEGG
D09730
Routes of administration
By mouth (tablets)
Interactions
Many different drugs can interact with LYNPARZA. Speak with your oncologist about all of the medications you are taking.
Example of drug interactions include:
- Amprenavir
- Aprepitant
- Atazanavir
- Boceprevir
- Bosentan
- Carbamazepine
- Ciprofloxacin
- Clarithromycin
- Crizotinib
- Darunavir/ritonavir
- Diltiazem
- Efavirenz
- Efavirenz
- Erythromycin
- Etravirine
- Fluconazole
- Fosamprenavir
- Imatinib
- Indiavir
- Itraconazole
- Ketoconazole
- Lopinavir/ritonavir
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Phenytoin
- Posaconazole
- Rifampicin
- Ritonavir
- Squinavir
- St. Join's Wort
- Telaprevir
- Telithromycin
- Verapamil
- Voriconazole
Cautions
The tablet and capsule forms are NOT interchangeable. Speak with your doctor if you need to switch from one formulation to another.
Do not drink grapefruit juice or Seville orange juice during treatment with Lynparza because they can increase the levels of the drug.
LYNPARZA is toxic to the developing fetus and should not be used by women who are pregnant. Women should not breastfeed while using this medication.
Myelodysplastic Syndrome/Acute Myeloid Leukemia (MDS/AML) is a rare, but fatal side effect of LYNPARZA. Your doctor should monitor for this condition.
Side Effects
Common LYNPARZA side effects can include:
- Anemia
- Arthralgia/myalgia
- Change in laboratory values
- Constipation
- Decreased appetite
- Diarrhea
- Dysgeusia
- Dyspepsia
- Fatigue
- Headache
- Influenza
- Leukopenia
- Nasopharyngitis
- Nausea
- Neutropenia
- Respiratory tract infection
- Stomatitis
- Upper respiratory infection
- Vomiting
References
- Lynparza [package insert]. Wilmington, DE: AstraZeneca; 2018.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13273
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