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Lyumjev (Insulin)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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LYUMJEV (Insulin aspart) is a prescription insulin product that can treat high blood sugar in people with diabetes mellitus. LYUMJEV is indicated to treat both type 1 and type 2 diabetes.
People with diabetes are not able to regulate their levels of blood glucose. They either (1) cannot produce enough insulin from their pancreas, or (2) they can produce insulin, but their body is resistant to it.
LYUMJEV replaces the missing insulin and helps to improve glycemic control.
Fact Table
Formula
C257H383N65O77S6
License
US FDA
Bioavailability
~55–60%
Legal status
Prescription only (Rx)
Chemical Name
Insulin Lispro-aabc
Elimination half-life
~1 hour; onset within ~1 minute
Dosage (Strength)
100 units/mL (U-100), 200 units/mL (U-200)
Pregnancy
Category B – No evidence of risk in humans
Brands
Lyumjev
Protein binding
Low
PubChem CID
16129678
MedlinePlus
a620041
ChEBI
6932
ATC code
A10AB
DrugBank
DB15672
KEGG
D11756
Routes of administration
Subcutaneous injection
Directions
Inject LYUMJEV subcutaneously at mealtime, between one and three times daily.
LYUMJEV is rapid-acting insulin and should be taking at the start of a meal or within 20 minutes after starting the meal.
Rotate injection sites to decrease the risk of lipodystrophy.
Store LYUMJEV in the refrigerator until opening. Once opened, it can be stored at room temperature for 28 days.
Ingredients
Insulin Aspart is the active ingredient in LYUMJEV.
Interactions
Some medications can interfere with blood sugar and increase it or decrease it. Changes to blood sugar may require the dose of insulin to be adjusted. Use caution if you are taking any of the following:
Alcohol
Atypical Antipsychotics
Corticosteroids
Disopyramide
Diuretics
Estrogens/Progesterones
Fibrates
Fluoxetine
Isoniazid
Lithium
Monoamine Oxidase Inhibitors (MAOIs)
Niacin
Oral antidiabetic agents
Pentoxifylline
Phenothiazine derivatives
Pramlintide
Propoxyphene
Protease inhibitors
Salicylates
Somatostatin Analogues
Somatropin
Sulfonamide Antibiotics
Sympathomimetic agents
Thyroid replacement medication
Cautions
Hypoglycemia is a common and dangerous side effect of insulin treatment. Some of the signs and symptoms include:
Anxiety
Confusion
Dizziness
Fatigue
Hunger
Irritability
Pale skin
Sweating
Tremor
Tell your doctor about any changes to your diet or activity because the dose of insulin may need to be adjusted.
Monitor blood sugar frequently while taking insulin or other antidiabetic agents.
The doctor may monitor the function of your heart, kidneys, and liver while taking insulin.
Lyumjev is an ultra-rapid-acting insulin analog used to control blood sugar spikes during meals in people with type 1 or type 2 diabetes. It contains insulin lispro-aabc.
How is Lyumjev different from Humalog?
Both contain insulin lispro, but Lyumjev is formulated to work faster due to added excipients (like citrate and treprostinil) that enhance absorption.
How quickly does Lyumjev start working?
Lyumjev starts working in about 1 minute, peaks in ~1 hour, and lasts for 4 to 5 hours.
When should I take Lyumjev?
Lyumjev should be taken at the start of a meal or within 20 minutes after beginning to eat.
How is Lyumjev administered?
It can be injected under the skin (subcutaneously) or used via an insulin pump. It comes in KwikPens, vials, and cartridges.
Is Lyumjev used with other insulins?
Yes. Lyumjev is a mealtime (bolus) insulin, often used with a basal insulin (like Lantus, Tresiba, or Basaglar).
Can Lyumjev be used in children?
Yes. Lyumjev is approved for children 1 year and older with diabetes, under medical supervision.
What are common side effects of Lyumjev?
Common side effects include:
Low blood sugar (hypoglycemia) Redness or irritation at injection site Weight gain
In use: Store at room temperature (below 86°F / 30°C) for up to 28 days Do not freeze.
Can Lyumjev be mixed with other insulins?
No. Lyumjev should not be mixed with any other insulin in the same syringe or infusion reservoir.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.