What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Malarone(Atovaquone + Proguanil)


Malarone(Atovaquone + Proguanil)

Prescription Required

Pediatric 62.5mg / 25mg
250mg / 100mg

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  • Product Details


    MALARONE is a prescription medication that can treat and prevent malaria infections. It contains a combination of two drugs that are both active against malaria parasites.

    MALARONE is often prescribed to travelers before they enter an area with high rates of malaria infection. It can also be used for treatment once an infection occurs.


    MALARONE tablets contain 250 mg of atovaquone and 100 mg of proguanil. Smaller doses are available for pediatric patients.

    Take MALARONE exactly as prescribed by your healthcare provider. MALARONE dosing depends on why it is being used:

    • Malaria prevention: Take one tablet by mouth once daily starting 1-2 days before entering an area with malaria and continue for seven days after leaving.
    • Malaria treatment: Take four tablets by mouth once daily for three days


    The active ingredients in MALARONE are atovaquone and proguanil.

    Atovaquone prevents the function of mitochondria in malarial cells.

    Proguanil inhibits the critical enzyme dihydrofolate reductase.

    When the malaria parasite enters the body, it has several different stages of development. During the initial infection, cells enter the liver before infecting red blood cells. MALARONE stops the development of malarial cells while they are in the liver. 


    MALARONE has many potential drug-drug interactions, and some of the most severe are with the following medications:

    • Antipsychotics
    • Dapsone
    • Efavirenz
    • Ethinyl estradiol (oral contraceptive)
    • Etoposide
    • Hepatitis C antivirals
    • Indinavir
    • Metoclopramide
    • Pyrimethamine
    • Rifamycin
    • Ritonavir
    • Tetracycline
    • Typhoid vaccine
    • Warfarin

    Speak with your doctor or pharmacist for a full list of drug interactions that may affect your treatment.


    MALARONE should be used with caution in people with a history of liver or kidney. Your doctor should monitor these before treatment with MALARONE.

    MALARONE may be less effective in patients who are obese (>100 kg).

    Tell your doctor if you have diarrhea or vomiting during treatment with MALARONE, which may decrease absorption.

    Side Effects

    MALARONE side effects can include:

    • Abdominal pain
    • Angioedema
    • Anorexia
    • Diarrhea
    • Dizziness
    • Pruritus
    • Hallucination
    • Headache
    • Increased liver enzymes
    • Nausea
    • Neutropenia
    • Urticaria
    • Vomiting
    • Weakness


    Malarone [package insert]. Research Park Triangle, NC: GlaxoSmithKline; 2008.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 1627

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