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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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MALARONE is a prescription medication that can treat and prevent malaria infections. It contains a combination of two drugs that are both active against malaria parasites.
MALARONE is often prescribed to travelers before they enter an area with high rates of malaria infection. It can also be used for treatment once an infection occurs.
MALARONE tablets contain 250 mg of atovaquone and 100 mg of proguanil. Smaller doses are available for pediatric patients.
Take MALARONE exactly as prescribed by your healthcare provider. MALARONE dosing depends on why it is being used:
The active ingredients in MALARONE are atovaquone and proguanil.
Atovaquone prevents the function of mitochondria in malarial cells.
Proguanil inhibits the critical enzyme dihydrofolate reductase.
When the malaria parasite enters the body, it has several different stages of development. During the initial infection, cells enter the liver before infecting red blood cells. MALARONE stops the development of malarial cells while they are in the liver.
MALARONE has many potential drug-drug interactions, and some of the most severe are with the following medications:
Speak with your doctor or pharmacist for a full list of drug interactions that may affect your treatment.
MALARONE should be used with caution in people with a history of liver or kidney. Your doctor should monitor these before treatment with MALARONE.
MALARONE may be less effective in patients who are obese (>100 kg).
Tell your doctor if you have diarrhea or vomiting during treatment with MALARONE, which may decrease absorption.
MALARONE side effects can include:
Malarone [package insert]. Research Park Triangle, NC: GlaxoSmithKline; 2008.