A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Matulane (Procarbazine)
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Product Details
Description
MATULANE (Procarbazine) is a prescription chemotherapy medication that treats certain types of cancers. MATULANE should only be used under the close supervision of an oncologist.
MATULANE is indicated for the treatment of Stage III and Stage IV Hodgkin’s disease. When treating Hodgkin’s disease, it should be used in combination with nitrogen mustard, vincristine, and prednisone (MOPP regimen).
MATULANE can also be used off-lab to treat CNS tumors, Non-Hodgkin lymphomas, and primary CNS lymphoma.
MATULANE works by preventing the replication of human cells by stopping the synthesis of DNA, RNA, and proteins. MATULANE targets cancer cells but can also affect non-cancerous cells.
Fact Table
Formula
C12H19N3O
License
US FDA
Bioavailability
-
Legal status
Rx-only
Chemical Name
Procarbazine
Elimination half-life
10 minutes
Dosage (Strength)
50mg
Pregnancy
Not recommended
Brands
Matulane, Natulan
Protein binding
-
PubChem CID
4915
MedlinePlus
a682094
ChEBI
71417
ATC code
L01XB01
DrugBank
DB01168
KEGG
D08423
Routes of administration
By mouth
Directions
The oncologist determines the dosing of MATULANE. Take it exactly as prescribed.
MATULANE is available as 50 mg capsules.
Ingredients
The active ingredient in MATULANE is procarbazine.
Interactions
Common drug-drug interactions can include:
BCG
Cladribine
Deferiprone
Dipyrone
Echinacea
Fingolimod
Inactivated vaccines
Iohexol
Iomeprol
Iopamidol
Leflunomide
Lenograstim
Lipefilgrastim
Live vaccines
Natalizumab
Nivolumab
Palifermin
Pimecrolimus
Roflumilast
Sipuleucel-T
Tacrolimus
Tofacitinib
Upadacitinib
Varicitinib
Cautions
MATULANE is a chemotherapeutic medication. Only purchase from a trusted source and with the permission of your oncologist.
MATULANE can cause suppression of bone marrow, are your doctor should monitor throughout treatment.
Do not drink alcohol while taking MATULANE.
There is a high risk of nausea, vomiting, and other gastrointestinal side effects while taking MATULANE.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Prescription Required
