What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Matulane (Procarbazine)


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Generic Equivalent - Matulane (Procarbazine)

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  • Product Details


    MATULANE (Procarbazine) is a prescription chemotherapy medication that treats certain types of cancers. MATULANE should only be used under the close supervision of an oncologist.

    MATULANE is indicated for the treatment of Stage III and Stage IV Hodgkin’s disease. When treating Hodgkin’s disease, it should be used in combination with nitrogen mustard, vincristine, and prednisone (MOPP regimen).

    MATULANE can also be used off-lab to treat CNS tumors, Non-Hodgkin lymphomas, and primary CNS lymphoma.

    MATULANE works by preventing the replication of human cells by stopping the synthesis of DNA, RNA, and proteins. MATULANE targets cancer cells but can also affect non-cancerous cells.

    Fact Table




    US FDA



    Legal status


    Chemical Name


    Elimination half-life

    10 minutes

    Dosage (Strength)



    Not recommended


    Matulane, Natulan

    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth


    The oncologist determines the dosing of MATULANE. Take it exactly as prescribed.

    MATULANE is available as 50 mg capsules.


    The active ingredient in MATULANE is procarbazine.


    Common drug-drug interactions can include:

    • BCG
    • Cladribine
    • Deferiprone
    • Dipyrone
    • Echinacea
    • Fingolimod
    • Inactivated vaccines
    • Iohexol
    • Iomeprol
    • Iopamidol
    • Leflunomide
    • Lenograstim
    • Lipefilgrastim
    • Live vaccines
    • Natalizumab
    • Nivolumab
    • Palifermin
    • Pimecrolimus
    • Roflumilast
    • Sipuleucel-T
    • Tacrolimus
    • Tofacitinib
    • Upadacitinib
    • Varicitinib


    MATULANE is a chemotherapeutic medication. Only purchase from a trusted source and with the permission of your oncologist.

    MATULANE can cause suppression of bone marrow, are your doctor should monitor throughout treatment.

    Do not drink alcohol while taking MATULANE.

    There is a high risk of nausea, vomiting, and other gastrointestinal side effects while taking MATULANE.

    Side Effects

    MATULANE side effects may include:

    • Black, tarry stools
    • Bone, joint, and muscle pain
    • Confusion
    • Constipation
    • Diarrhea
    • Difficulty sleeping
    • Dizziness
    • Dry mouth
    • Fainting
    • Hair loss
    • Hallucinations
    • Headache
    • Low appetite
    • Nausea
    • Prickling or tingling of the hand or feet
    • Seizures
    • Sores in the mouth and throat
    • Stomach pain
    • Tremor
    • Vision changes
    • Vomiting
    • Yellowing of the skin or eyes


    1. Matulane [package insert]. Wilmington, NC: Leadiant Biosciences; 2019.

    Frequently Asked Questions about Matulane (Procarbazine)

    What is Matulane (Procarbazine)?

    Matulane is a prescription medication that contains the active ingredient procarbazine. It belongs to a class of drugs known as alkylating agents and is primarily used in the treatment of certain types of cancer, including Hodgkin's lymphoma.

    How does Matulane work?

    Matulane works by interfering with the DNA and RNA in cancer cells, preventing their growth and replication. It is particularly effective in targeting fast-growing cancer cells.

    What types of cancer can Matulane treat?

    Matulane is mainly used in the treatment of Hodgkin's lymphoma, a type of cancer that affects the lymphatic system. It may also be prescribed for other types of cancer at the discretion of a healthcare provider.

    Is Matulane available over-the-counter (OTC)?

    No, Matulane is not available over-the-counter. It is a prescription medication, and you must consult a healthcare provider to obtain it.

    How is Matulane administered?

    Matulane is typically administered orally in the form of capsules. The dosage and treatment regimen will be determined by your healthcare provider based on your specific condition.

    Are there any side effects associated with Matulane?

    Yes, like many cancer medications, Matulane can have side effects. Common side effects may include nausea, vomiting, loss of appetite, and changes in blood counts. It's essential to discuss potential side effects with your healthcare provider.

    Can I take other medications while on Matulane?

    It's crucial to inform your healthcare provider about all the medications, supplements, or herbal remedies you are taking, as some may interact with Matulane and affect its effectiveness.

    Is it safe to use Matulane during pregnancy or while breastfeeding?

    Matulane can harm an unborn baby, so it should not be used during pregnancy. If you are breastfeeding, consult your healthcare provider, as Matulane may pass into breast milk and could be harmful to a nursing infant.

    How often will I need to undergo medical tests while taking Matulane?

    Your healthcare provider will schedule regular medical tests to monitor your progress and check for any potential side effects or complications associated with Matulane treatment. Follow your provider's recommendations closely.

    Can Matulane be used in combination with other cancer treatments?

    Matulane is often used in combination with other cancer treatments, such as radiation therapy or chemotherapy. Your healthcare provider will determine the most suitable treatment plan for your specific cancer diagnosis.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 11311

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