What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Matulane (Procarbazine)


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Generic Equivalent - Matulane (Procarbazine)

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  • Product Details


    MATULANE (Procarbazine) is a prescription chemotherapy medication that treats certain types of cancers. MATULANE should only be used under the close supervision of an oncologist.

    MATULANE is indicated for the treatment of Stage III and Stage IV Hodgkin’s disease. When treating Hodgkin’s disease, it should be used in combination with nitrogen mustard, vincristine, and prednisone (MOPP regimen).

    MATULANE can also be used off-lab to treat CNS tumors, Non-Hodgkin lymphomas, and primary CNS lymphoma.

    MATULANE works by preventing the replication of human cells by stopping the synthesis of DNA, RNA, and proteins. MATULANE targets cancer cells but can also affect non-cancerous cells.

    Fact Table




    US FDA



    Legal status


    Chemical Name


    Elimination half-life

    10 minutes

    Dosage (Strength)



    Not recommended


    Matulane, Natulan

    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth


    The oncologist determines the dosing of MATULANE. Take it exactly as prescribed.

    MATULANE is available as 50 mg capsules.


    The active ingredient in MATULANE is procarbazine.


    Common drug-drug interactions can include:

    • BCG
    • Cladribine
    • Deferiprone
    • Dipyrone
    • Echinacea
    • Fingolimod
    • Inactivated vaccines
    • Iohexol
    • Iomeprol
    • Iopamidol
    • Leflunomide
    • Lenograstim
    • Lipefilgrastim
    • Live vaccines
    • Natalizumab
    • Nivolumab
    • Palifermin
    • Pimecrolimus
    • Roflumilast
    • Sipuleucel-T
    • Tacrolimus
    • Tofacitinib
    • Upadacitinib
    • Varicitinib


    MATULANE is a chemotherapeutic medication. Only purchase from a trusted source and with the permission of your oncologist.

    MATULANE can cause suppression of bone marrow, are your doctor should monitor throughout treatment.

    Do not drink alcohol while taking MATULANE.

    There is a high risk of nausea, vomiting, and other gastrointestinal side effects while taking MATULANE.

    Side Effects

    MATULANE side effects may include:

    • Black, tarry stools
    • Bone, joint, and muscle pain
    • Confusion
    • Constipation
    • Diarrhea
    • Difficulty sleeping
    • Dizziness
    • Dry mouth
    • Fainting
    • Hair loss
    • Hallucinations
    • Headache
    • Low appetite
    • Nausea
    • Prickling or tingling of the hand or feet
    • Seizures
    • Sores in the mouth and throat
    • Stomach pain
    • Tremor
    • Vision changes
    • Vomiting
    • Yellowing of the skin or eyes


    1. Matulane [package insert]. Wilmington, NC: Leadiant Biosciences; 2019.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 11311

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