Mekinist (Trametinib)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Mekinist (trametinib) is a prescription medication used for treating the following conditions:
- A type of skin cancer called melanoma that contains a certain type of abnormal gene and has spread to other parts of the body or cannot be surgically removed
- Preventing melanoma with a certain type of abnormal gene from coming back once it has been surgically removed
- Non-small cell lung cancer with a certain type of abnormal gene that has spread to other parts of the body
- Low-grade glioma, a type of brain tumor, with a certain type of abnormal gene in children who are at least 1 years old and require systemic treatment
- Thyroid cancer containing a certain type of abnormal gene that has advanced or spread to other parts of the body and could not be adequately treated with locoregional therapies
Mekinist is available as an oral tablet in 0.5 mg and 2 mg strengths. It is also available in a 4.7 mg oral solution.
Directions
Take Mekinist exactly as prescribed by your doctor. Carefully read the medication guide that comes with your prescription.
Mekinist dosing:
Your doctor will decide on an appropriate treatment plan and dose for you based on your condition, age, and body weight. The medication is recommended to be taken at least 1 hour before or 2 hours after a meal.
Mekinist storage:
Keep Mekinist tablets in their original container in the refrigerator between 2°C to 8°C (36°F to 46°F). Keep out of light and away from moisture. Do not throw away the desiccant packet that is in the bottle; it helps keep the medication dry.
Keep reconstituted Mekinist oral solution in the original bottle below 25°C (77°F); avoid freezing. Properly dispose of the oral solution after the “discard after” date that is written on the bottle.
Keep the medication out of reach of children.
If you have any questions or concerns regarding your Mekinist prescription, contact your doctor or pharmacist.
Ingredients
The active ingredient in Mekinist is trametinib.
Inactive ingredients in the tablets include colloidal silicon dioxide, croscarmellose sodium, hypromellose, magnesium stearate (vegetable source), mannitol, microcrystalline cellulose, sodium lauryl sulfate, hypromellose, iron oxide red (2 mg tablets), iron oxide yellow (0.5 mg tablets), polyethylene glycol, polysorbate 80 (2 mg tablets), and titanium dioxide.
Inactive ingredients in the oral solution include betadex sulfobutyl ether sodium, citric acid monohydrate, dibasic sodium phosphate, methylparaben, potassium sorbate, sucralose, and strawberry flavor.
Contraindications
There are no contraindications to Mekinist per the most recent Prescribing Information.
Cautions
- Before you begin treatment with Mekinist, tell your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Mekinist is associated with the following warnings and precautions:
- Development of new cancers
- Major bleeding events
- Inflammation of the colon and perforation of the gastrointestinal tract
- Blood clots
- Heart muscle disease
- Vision problems
- Lung problems
- Serious fever when taken with dabrafenib
- Serious skin problems
- High blood glucose levels
- Hemophagocytic lymphohistiocytosis
- Harm to an unborn baby; females of childbearing potential are advised to use effective contraception during treatment with Mekinist and for 4 months after taking the final dose.
Side Effects
Rash, diarrhea, and lymphedema are common Mekinist side effects. However, other side effects may also occur. Immediately contact your doctor if you experience side effects that bother you or won’t go away.
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Reference:
Mekinist. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14550
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