What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Migranal Nasal Spray (Dihydroergotamine)
Prescription Required
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Product Details
Description
Dihydroergotamine Mesylate is often prescribed for the treatment of migraines and headaches when other forms of treatment have not been successful. It is inhaled through the nostrils to provide quick relief of headaches as they start.
Dihydroergotamine Mesylate works by tightening the blood vessels in the brain, which leads to a decrease in pain signals. If blood vessels are too relaxed, this can push into the surrounding tissue and cause inflammation that leads to headaches.
Fact Table
Formula
C33H37N5O5
License
US FDA, EU EMA
Bioavailability
32%
Legal status
Rx-only
Chemical Name
Dihydroergotamine
Elimination half-life
9 hours
Dosage (Strength)
0.5mg
Pregnancy
Consult Doctor
Brands
Migranal, Trudhesa
Protein binding
93%
PubChem CID
10531
MedlinePlus
a603022
ChEBI
4562
ATC code
N02CA01
DrugBank
DB00722
KEGG
D07837
Routes of administration
Nasal
Directions
The standard dosage is to inhale one inhalation through the nose at the onset of symptoms. Repeat every hour as needed, do not exceed 3 mg per 24 hour period. Do not exceed 6 mg in a week.
Taking more than the recommended maximum can lead to rebound headache and worsening of pain and other symptoms.
Ingredients
The active ingredient is Dihydroergotamine Mesylate.
Interactions
There are many drug-drug interactions with this medication, including:
- Abametapir
- Alpha-/Beta-Agonists
- Alpha1-Agonists
- Bromocriptine
- Atazanavir
- Ceritinib
- Clarithromycin
- Cobicistat and cobicistat-containing coformulations
- Darunavir
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Levoketoconazole
- Lonafarnib
- Lopinavir
- Mifepristone
- Nefazodone
- Nelfinavir
- Ombitasvir-paritaprevir-ritonavir
- Ombitasvir-paritaprevir-ritonavir plus dasabuvir
- Posaconazole
- Ritonavir and ritonavir-containing coformulations
- Saquinavir
- Telithromycin
- Tucatinib
- Voriconazole
- Erythromycin
- Fosamprenavir
- Roxithromycin
- Triptans
- Tipranavir
- Nitroglycerin
Cautions
Tell your doctor if you have a history of valvular heart disease before taking this drug.
This medication has been associated with serious and life threatening ischemia.
Use caution if you have a prior history of stroke.
Side Effects
Dihydroergotamine mesylate nasal spray side effects can include:
- Altered sense of smell
- Asthgenia
- Burning sensation of the nose
- Diarrhea
- Drowsiness
- Dry nose
- Dysgeusia
- Ear discomfort
- Epistaxis
- Hot flash
- Nasal cavity pain
- Nasal congestion
- Nasal discomfort
- Nasal mucosal irritation
- Nasal sore
- Nasopharyngitis
- Nausea
- Pharyngitis
- Rhinitis
- Rhinorrhea
- Sinus discomfort
- Stiffness
- Vomiting
Tell your pharmacist and doctor if you experience any of the above while taking this medication.
References
Dihydroergotamine. East Hanover, New Jersey: Novartis; year.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10122
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