What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Minivelle (Estradiol transdermal System)


Minivelle (Estradiol transdermal System)

Prescription Required

0.025mg (1 package of 8 patches)
0.025mg (1 package of 8 patches)
0.0375mg (1 package of 8 patches)
0.0375mg (1 package of 8 patches)
0.05mg (1 package of 8 patches)
0.075mg (1 package of 8 patches)
0.075mg (1 package of 8 patches)
0.1mg (1 package of 8 patches)

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  • Product Details


    Minivelle is an estrogen replacement product that is used for women undergoing menopause. It can help treat vasomotor symptoms like hot flashes and night sweats.

    Fact Table




    EU EMA


    Less than 5%

    Legal status


    Chemical Name


    Elimination half-life

    Oral: 13ÔÇô20 hours

    Dosage (Strength)

    0.025mg, 0.0375mg, 0.05mg, 0.075mg, 0.1mg


    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    Oral, sublingual, intranasal, topical/transdermal, vaginal, intramuscular or subcutaneous (as an ester), subdermal implant


    The standard dosage is Minivelle 0.375 mg twice weekly. The dose can be adjusted based on your response to the medication.


    The active ingredient in the Minivelle dose patch is estradiol. Estradiol is a synthetic estrogen product.


    Talk to your doctor if you experience any of the following while taking Minivelle.

    • Abametapir
    • Anastrozole
    • Cosyntropin
    • Dehydroepiandrosterone
    • Exemestane
    • Fexinidazole
    • Fusidic Acid
    • Growth hormone analogs
    • Hemin
    • Indium 111 capromab pendetide
    • Ospemifene
    • TiZANidine
    • Tranexamic acid


    Minivelle should not be used by people who have a history of clotting disorders, like a heart attack or stroke.

    Tell your doctor if you have a history of kidney disease, liver disease, or other long-term health conditions.

    Side Effects

    Some of the most common adverse reactions to this medication may include:

    • Abdominal distention
    • Abdominal pain
    • Abnormal uterine bleeding
    • Accidental injury
    • Acne vulgaris
    • Anxiety
    • Arthralgia
    • Asthenia
    • Back pain
    • Breakthrough bleeding
    • Breast hypertrophy
    • Breast tenderness
    • Bronchitis
    • Cervical polyp
    • Constipation
    • Depression
    • Dizziness
    • Dysmenorrhea
    • Dyspepsia
    • Edema
    • Endometrium disease
    • Fatigue
    • Flatulence
    • Flu-like symptoms
    • Fungal infection
    • Gastroenteritis
    • Headache
    • Hirsutism
    • Hot flashes
    • Hypertension
    • Intermenstrual bleeding
    • Leukorrhea
    • Limb pain
    • Mastalgia
    • Myalgia
    • Nasopharyngitis
    • Nausea
    • Neck pain
    • Nipple pain
    • Pain
    • Paranasal sinus congestion
    • Pharyngitis
    • Pruritus
    • Rhinitis
    • Sinus headache
    • Sinusitis
    • Skin rash
    • Upper respiratory tract infection
    • Urinary tract infection
    • Uterine pain
    • Vaginal discharge
    • Vaginal hemorrhage
    • Vaginal mycosis
    • Vulvovaginal candidiasis
    • Weight gain

    If you experience any of the above side effects, do not immediately stop your medication, but call your doctor and pharmacist. Certain side effects are temporary, but some may lost long term in certain people.


    Minivelle (Estradiol) Miami, FL: Noven Pharmaceuticals Inc.; 2012.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13583

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