Description
Minivelle is an estrogen replacement product that is used for women undergoing menopause. It can help treat vasomotor symptoms like hot flashes and night sweats.
Fact Table |
Formula |
C18H24O2 |
License |
EU EMA |
Bioavailability |
Less than 5% |
Legal status |
Rx-Only |
Chemical Name |
Estradiol |
Elimination half-life |
Oral: 13–20 hours |
Dosage (Strength) |
0.025mg, 0.0375mg, 0.05mg, 0.075mg, 0.1mg |
Pregnancy |
Consult Doctor |
Brands |
Minivelle |
Protein binding |
~98% |
PubChem CID |
5816 |
MedlinePlus |
a603002 |
ChEBI |
5757 |
ATC code |
G03CA03 |
DrugBank |
DB00783 |
KEGG |
D00105 |
Routes of administration |
Oral, sublingual, intranasal, topical/transdermal, vaginal, intramuscular or subcutaneous (as an ester), subdermal implant |
Directions
The standard dosage is Minivelle 0.375 mg twice weekly. The dose can be adjusted based on your response to the medication.
Ingredients
The active ingredient in the Minivelle dose patch is estradiol. Estradiol is a synthetic estrogen product.
Interactions
Talk to your doctor if you experience any of the following while taking Minivelle.
- Abametapir
- Anastrozole
- Cosyntropin
- Dehydroepiandrosterone
- Exemestane
- Fexinidazole
- Fusidic Acid
- Growth hormone analogs
- Hemin
- Indium 111 capromab pendetide
- Ospemifene
- TiZANidine
- Tranexamic acid
Cautions
Minivelle should not be used by people who have a history of clotting disorders, like a heart attack or stroke.
Tell your doctor if you have a history of kidney disease, liver disease, or other long-term health conditions.
Side Effects
Some of the most common adverse reactions to this medication may include:
- Abdominal distention
- Abdominal pain
- Abnormal uterine bleeding
- Accidental injury
- Acne vulgaris
- Anxiety
- Arthralgia
- Asthenia
- Back pain
- Breakthrough bleeding
- Breast hypertrophy
- Breast tenderness
- Bronchitis
- Cervical polyp
- Constipation
- Depression
- Dizziness
- Dysmenorrhea
- Dyspepsia
- Edema
- Endometrium disease
- Fatigue
- Flatulence
- Flu-like symptoms
- Fungal infection
- Gastroenteritis
- Headache
- Hirsutism
- Hot flashes
- Hypertension
- Intermenstrual bleeding
- Leukorrhea
- Limb pain
- Mastalgia
- Myalgia
- Nasopharyngitis
- Nausea
- Neck pain
- Nipple pain
- Pain
- Paranasal sinus congestion
- Pharyngitis
- Pruritus
- Rhinitis
- Sinus headache
- Sinusitis
- Skin rash
- Upper respiratory tract infection
- Urinary tract infection
- Uterine pain
- Vaginal discharge
- Vaginal hemorrhage
- Vaginal mycosis
- Vulvovaginal candidiasis
- Weight gain
If you experience any of the above side effects, do not immediately stop your medication, but call your doctor and pharmacist. Certain side effects are temporary, but some may lost long term in certain people.
References
Minivelle (Estradiol) Miami, FL: Noven Pharmaceuticals Inc.; 2012.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13583