What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Minivelle (Estradiol transdermal System)


Minivelle (Estradiol transdermal System)

Prescription Required

0.025mg (1 package of 8 patches)
0.025mg (1 package of 8 patches)
0.0375mg (1 package of 8 patches)
0.0375mg (1 package of 8 patches)
0.05mg (1 package of 8 patches)
0.075mg (1 package of 8 patches)
0.075mg (1 package of 8 patches)
0.1mg (1 package of 8 patches)

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  • Product Details


    Minivelle is an estrogen replacement product that is used for women undergoing menopause. It can help treat vasomotor symptoms like hot flashes and night sweats.

    Fact Table




    EU EMA


    Less than 5%

    Legal status


    Chemical Name


    Elimination half-life

    Oral: 13ÔÇô20 hours

    Dosage (Strength)

    0.025mg, 0.0375mg, 0.05mg, 0.075mg, 0.1mg


    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    Oral, sublingual, intranasal, topical/transdermal, vaginal, intramuscular or subcutaneous (as an ester), subdermal implant


    The standard dosage is Minivelle 0.375 mg twice weekly. The dose can be adjusted based on your response to the medication.


    The active ingredient in the Minivelle dose patch is estradiol. Estradiol is a synthetic estrogen product.


    Talk to your doctor if you experience any of the following while taking Minivelle.

    • Abametapir
    • Anastrozole
    • Cosyntropin
    • Dehydroepiandrosterone
    • Exemestane
    • Fexinidazole
    • Fusidic Acid
    • Growth hormone analogs
    • Hemin
    • Indium 111 capromab pendetide
    • Ospemifene
    • TiZANidine
    • Tranexamic acid


    Minivelle should not be used by people who have a history of clotting disorders, like a heart attack or stroke.

    Tell your doctor if you have a history of kidney disease, liver disease, or other long-term health conditions.

    Side Effects

    Some of the most common adverse reactions to this medication may include:

    • Abdominal distention
    • Abdominal pain
    • Abnormal uterine bleeding
    • Accidental injury
    • Acne vulgaris
    • Anxiety
    • Arthralgia
    • Asthenia
    • Back pain
    • Breakthrough bleeding
    • Breast hypertrophy
    • Breast tenderness
    • Bronchitis
    • Cervical polyp
    • Constipation
    • Depression
    • Dizziness
    • Dysmenorrhea
    • Dyspepsia
    • Edema
    • Endometrium disease
    • Fatigue
    • Flatulence
    • Flu-like symptoms
    • Fungal infection
    • Gastroenteritis
    • Headache
    • Hirsutism
    • Hot flashes
    • Hypertension
    • Intermenstrual bleeding
    • Leukorrhea
    • Limb pain
    • Mastalgia
    • Myalgia
    • Nasopharyngitis
    • Nausea
    • Neck pain
    • Nipple pain
    • Pain
    • Paranasal sinus congestion
    • Pharyngitis
    • Pruritus
    • Rhinitis
    • Sinus headache
    • Sinusitis
    • Skin rash
    • Upper respiratory tract infection
    • Urinary tract infection
    • Uterine pain
    • Vaginal discharge
    • Vaginal hemorrhage
    • Vaginal mycosis
    • Vulvovaginal candidiasis
    • Weight gain

    If you experience any of the above side effects, do not immediately stop your medication, but call your doctor and pharmacist. Certain side effects are temporary, but some may lost long term in certain people.


    Minivelle (Estradiol) Miami, FL: Noven Pharmaceuticals Inc.; 2012.

    Frequently Asked Questions about Minivelle

    What is Minivelle?

    Minivelle is a prescription medication that contains estradiol, a type of estrogen hormone. It is used as hormone replacement therapy (HRT) to treat menopausal symptoms in women, such as hot flashes, vaginal dryness, and night sweats.

    How does Minivelle work?

    Minivelle works by replenishing the declining levels of estrogen in the body that occur during menopause. By providing a controlled dose of estrogen through a patch applied to the skin, it helps alleviate menopausal symptoms.

    What forms does Minivelle come in?

    Minivelle is available in the form of transdermal patches, which are applied to the skin. These patches release a continuous, low dose of estrogen over a specific period, typically 3 to 4 days.

    Who can benefit from using Minivelle?

    Minivelle is primarily prescribed to women experiencing menopausal symptoms, including those who have had a hysterectomy. It can help relieve symptoms like hot flashes, vaginal dryness, and mood changes associated with menopause.

    Are there any side effects associated with Minivelle?

    Like any medication, Minivelle may have side effects. Common side effects can include skin irritation at the patch application site, breast tenderness, and nausea. It's essential to discuss potential side effects with your healthcare provider.

    Can I use Minivelle if I have a history of breast cancer?

    Women with a history of breast cancer should consult with their healthcare provider before considering Minivelle or any hormone replacement therapy. The decision to use HRT should be made on an individual basis, considering the risks and benefits.

    How should I apply Minivelle patches?

    Minivelle patches are typically applied to clean, dry, and unbroken skin on the lower abdomen or buttocks area. It's essential to follow the specific instructions provided with the medication for proper application.

    Can I swim or bathe while wearing Minivelle patches?

    Minivelle patches are designed to be water-resistant, so you can swim or bathe while wearing them. However, it's advisable to avoid prolonged exposure to hot water, saunas, or excessive sweating, as this may affect patch adhesion.

    Can I use Minivelle if I have a history of blood clots or cardiovascular issues?

    Women with a history of blood clots, stroke, or certain cardiovascular conditions may not be suitable candidates for Minivelle or other estrogen-based hormone therapies. It's crucial to discuss your medical history with your healthcare provider.

    Is Minivelle available over the counter (OTC)?

    No, Minivelle is a prescription medication and is not available over the counter. It should only be used under the supervision and guidance of a healthcare provider.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13583

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