A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Moduretic (Amiloride/HCTZ)
Also Known as .
Brand
Moduretic (Amiloride/HCTZ)
Prescription Required
Strength
Qty
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Moduretic is a prescription that contains a combination of the drugs amiloride and hydrochlorothiazide.
Your doctor may prescribe Moduretic to treat heart failure, hypertension, or both conditions.
Hypertension is another term for high blood pressure. Hypertension is a chronic condition where the blood pushes too forcefully on the blood vessel walls. Over time, the increased pressure can cause organ damage, heart attack, or stroke.
In heart failure, one or more chambers of the heart cannot squeeze hard enough to push blood through the blood vessels. Blood may pool in the limbs or lungs, impacting the quality of life.
Fact Table
Formula
C6H8ClN7O
License
US FDA
Bioavailability
Readily absorbed, 15–25%
Legal status
Rx-only
Chemical Name
Amiloride
Elimination half-life
6 to 9 hours
Dosage (Strength)
5/50mg
Pregnancy
Consult Doctor
Brands
Moduretic
Protein binding
~23%
PubChem CID
16231
MedlinePlus
a615029
ChEBI
2639
ATC code
C03DB01
DrugBank
DB00594
KEGG
D07447
Routes of administration
By mouth
Directions
The ingredients in Moduretic 5-50 mg are amiloride and hydrochlorothiazide.
The starting Moduretic dose is 1 tablet by mouth once daily. Your doctor may increase the dose to 2 tablets per day.
Ingredients
Moduretic contains two active ingredients.
Amiloride is a potassium-sparing diuretic. It works in the kidneys to promote the urination of extra fluid to decrease the workload on the heart.
Hydrochlorothiazide is a thiazide diuretic. It also works in the kidneys to increase urination and decrease the fluid-load on the heart.
Interactions
Tell your doctor or pharmacist if you are taking any of the following:
Bile acid sequestrants
Cyclosporine
Dofetilide
Eplerenone
Lithium
Obinutuzumab
Potassium salts
Promazine
Spironolactone
Topiramate
Cautions
Tell your doctor if you have an allergy to sulfa (sulfonamide drugs) before taking Moduretic.
You may become more sensitive to the sun and artificial sunlight while taking this medicine.
Your doctor should monitor for changes in your electrolytes while taking Moduretic.
This is not a complete list of precautions. Talk to your doctor or pharmacist for more information.
Side Effects
The common side effect of Moduretic may include:
Dizziness
Headache
Hyperkalemia
Nausea
Skin rash
Weakness
References
Amiloride and Hydrochlorothiazide [package insert]. Morgantown, WV: Mylan; 2020.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Prescription Required
