What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Moduretic (Amiloride/HCTZ)


Moduretic (Amiloride/HCTZ)

Prescription Required

5mg / 50mg

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  • Product Details


    Moduretic is a prescription that contains a combination of the drugs amiloride and hydrochlorothiazide.

    Your doctor may prescribe Moduretic to treat heart failure, hypertension, or both conditions.

    Hypertension is another term for high blood pressure. Hypertension is a chronic condition where the blood pushes too forcefully on the blood vessel walls. Over time, the increased pressure can cause organ damage, heart attack, or stroke.

    In heart failure, one or more chambers of the heart cannot squeeze hard enough to push blood through the blood vessels. Blood may pool in the limbs or lungs, impacting the quality of life.

    Fact Table




    US FDA


    Readily absorbed, 15–25%

    Legal status


    Chemical Name


    Elimination half-life

    6 to 9 hours

    Dosage (Strength)



    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth


    The ingredients in Moduretic 5-50 mg are amiloride and hydrochlorothiazide.

    The starting Moduretic dose is 1 tablet by mouth once daily. Your doctor may increase the dose to 2 tablets per day.


    Moduretic contains two active ingredients.

    Amiloride is a potassium-sparing diuretic. It works in the kidneys to promote the urination of extra fluid to decrease the workload on the heart.

    Hydrochlorothiazide is a thiazide diuretic. It also works in the kidneys to increase urination and decrease the fluid-load on the heart.


    Tell your doctor or pharmacist if you are taking any of the following:

    • Bile acid sequestrants
    • Cyclosporine
    • Dofetilide
    • Eplerenone
    • Lithium
    • Obinutuzumab
    • Potassium salts
    • Promazine
    • Spironolactone
    • Topiramate


    Tell your doctor if you have an allergy to sulfa (sulfonamide drugs) before taking Moduretic. 

    You may become more sensitive to the sun and artificial sunlight while taking this medicine.

    Your doctor should monitor for changes in your electrolytes while taking Moduretic.

    This is not a complete list of precautions. Talk to your doctor or pharmacist for more information.

    Side Effects

    The common side effect of Moduretic may include:

    • Dizziness
    • Headache
    • Hyperkalemia
    • Nausea
    • Skin rash
    • Weakness


    1. Amiloride and Hydrochlorothiazide [package insert]. Morgantown, WV: Mylan; 2020.

    Frequently Asked Questions about Moduretic (Amiloride/HCTZ)

    What is Moduretic (Amiloride/HCTZ)?

    Moduretic is a prescription medication that combines two active ingredients, Amiloride and Hydrochlorothiazide (HCTZ). It is classified as a diuretic and is used to treat high blood pressure (hypertension) and reduce fluid retention (edema) in certain medical conditions.

    How does Moduretic work to lower blood pressure and reduce fluid retention?

    Moduretic contains two components. Amiloride helps the kidneys remove excess salt and water from the body, which can lower blood pressure and reduce fluid buildup. Hydrochlorothiazide (HCTZ) further enhances water and salt removal by increasing urine production.

    Who is a candidate for Moduretic treatment?

    Moduretic may be prescribed to adults with high blood pressure or edema associated with conditions like heart failure or kidney problems. It should be prescribed by a healthcare provider after a thorough evaluation of your medical history and condition.

    What are the common side effects of Moduretic?

    Common side effects of Moduretic may include increased urination, dizziness, headache, muscle cramps, and changes in blood potassium levels. These side effects are typically mild and can be managed with your healthcare provider's guidance.

    How should I take Moduretic?

    Moduretic is usually taken orally as directed by your healthcare provider. It's essential to follow the prescribed dosage and instructions carefully. You may be advised to take it with or without food, and your doctor will determine the appropriate dose.

    Can Moduretic cure high blood pressure or edema?

    Moduretic can effectively manage high blood pressure and reduce fluid retention, but it does not cure these conditions. It helps control symptoms and reduce the risk of complications associated with high blood pressure or edema.

    Can I drink alcohol while taking Moduretic?

    It is advisable to limit alcohol consumption or avoid it altogether while taking Moduretic, as alcohol can enhance its blood pressure-lowering effects and increase the risk of side effects like dizziness.

    Are there any special considerations for pregnant or breastfeeding individuals?

    Moduretic may not be recommended during pregnancy or breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, consult with your healthcare provider to discuss the potential risks and benefits. Alternative treatments may be considered.

    What should I do if I miss a dose of Moduretic?

    If you miss a dose of Moduretic, take it as soon as you remember, unless it's close to your next scheduled dose. Do not double dose to make up for a missed one. Follow your regular dosing schedule.

    How often should I see my healthcare provider while taking Moduretic?

    Regular follow-up appointments with your healthcare provider are important while taking Moduretic. They will monitor your blood pressure, kidney function, and overall health to ensure that the medication is working effectively and without any complications.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 10125

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