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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Motilium (Domperidone)

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Generic

What is a Generic?

Generic Equivalent - Motilium (Domperidone)

Prescription Required

Strength
Qty
10mg

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  • Product Details

    Description

    Motilium is a medication used to treat delayed gastric emptying that can cause symptoms like nausea, vomiting, bloating, fullness, and abdominal discomfort.

    Motilium works by blocking dopamine receptors in the gastrointestinal tract, which stimulates muscle contraction and increases food movement through the stomach and intestines.

    Motilium is not approved for use by the Food and Drug Administration in the United States but is available in other countries.


    Fact Table

    Formula

    C22H24ClN5O2

    License

    US DailyMed

    Bioavailability

    Oral: 13–17%

    Legal status

    Rx-Only

    Chemical Name

    Domperidone

    Elimination half-life

    7–9 hours

    Dosage (Strength)

    -

    Pregnancy

    Consult Doctor

    Brands

    Motilium

    Protein binding

    92%

    PubChem CID

    3151

    MedlinePlus

    -

    ChEBI

    31515

    ATC code

    A03FA03

    DrugBank

    DB01184

    KEGG

    D01745

    Routes of administration

    By mouth

    Directions

    The usual dosage of Motilium is 30-40 mg by mouth three to four times daily. It should be taken 15-30 minutes before meals. It is available in 10 mg tablets.

    Ingredients

    The active ingredient in Motilium is domperidone.

    Interactions

    Common drug-drug interactions with Motilium include:

    • Adagrasib
    • Anticholinergic Agents
    • Atazanavir
    • Bromocriptine
    • Ceritinib
    • Clarithromycin
    • Cobicistat and cobicistat-containing coformulations
    • Darunavir
    • Fosfomycin
    • Fusidic Acid (Systemic)
    • Haloperidol
    • Idelalisib
    • Indinavir
    • Itraconazole
    • Ketoconazole
    • Lefamulin
    • Levoketoconazole
    • Levoketoconazole
    • Levosulpiride
    • Lonafarnib
    • Lopinavir
    • Mifepristone
    • Monoamine Oxidase Inhibitors
    • Nefazodone
    • Nelfinavir
    • Nirmatrelvir-ritonavir
    • Ombitasvir-paritaprevir-ritonavir
    • Ombitasvir-paritaprevir-ritonavir plus dasabuvir
    • Ondansetron
    • Opioid Agonists
    • Pentamidine (Systemic)
    • Pimozide
    • Posaconazole
    • Posaconazole
    • QT-prolonging Agents
    • Ritonavir and ritonavir-containing coformulations
    • Saquinavir
    • Sertindole
    • Sirolimus
    • Telithromycin
    • Tucatinib
    • Voriconazole

    Cautions

    Tell your doctor if you have a history of liver disease or are currently taking medication that affects your heart rhythm. Motilium can cause changes in heart rhythm and potentially serious side effects.

    Motilium is not recommended for pregnant or breastfeeding women without consulting a healthcare professional.

    Motilium can cause increases in prolactin levels, which can cause low libido, headaches, breast discharge, and breast growth in males.

    Side Effects

    The most common adverse reactions may include:

    • Abdominal cramps
    • Acid regurgitation
    • Asthenia
    • Change in appetite
    • Constipation
    • Diarrhea
    • Dizziness
    • Galactorrhea not associated with childbirth
    • Gynecomastia
    • Headache
    • Heartburn
    • Hot flash
    • Increased serum cholesterol
    • Increased serum prolactin
    • Increased thirst
    • Insomnia
    • Irritability
    • Lethargy
    • Migraine
    • Nausea
    • Nervousness
    • Stomatitis
    • Xerostomia

    References

    1. Motilium [package insert]. Auckland, NZ: Johnson and Johnson; 2022.

    Dr Conor Sheehy
    About Dr. Conor Sheehy (Page Author)

    Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 10539

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