What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Motilium (Domperidone)


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Generic Equivalent - Motilium (Domperidone)

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  • Product Details


    Motilium is a medication used to treat delayed gastric emptying that can cause symptoms like nausea, vomiting, bloating, fullness, and abdominal discomfort.

    Motilium works by blocking dopamine receptors in the gastrointestinal tract, which stimulates muscle contraction and increases food movement through the stomach and intestines.

    Motilium is not approved for use by the Food and Drug Administration in the United States but is available in other countries.

    Fact Table




    US DailyMed


    Oral: 13–17%

    Legal status


    Chemical Name


    Elimination half-life

    7–9 hours

    Dosage (Strength)



    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth


    The usual dosage of Motilium is 30-40 mg by mouth three to four times daily. It should be taken 15-30 minutes before meals. It is available in 10 mg tablets.


    The active ingredient in Motilium is domperidone.


    Common drug-drug interactions with Motilium include:

    • Adagrasib
    • Anticholinergic Agents
    • Atazanavir
    • Bromocriptine
    • Ceritinib
    • Clarithromycin
    • Cobicistat and cobicistat-containing coformulations
    • Darunavir
    • Fosfomycin
    • Fusidic Acid (Systemic)
    • Haloperidol
    • Idelalisib
    • Indinavir
    • Itraconazole
    • Ketoconazole
    • Lefamulin
    • Levoketoconazole
    • Levoketoconazole
    • Levosulpiride
    • Lonafarnib
    • Lopinavir
    • Mifepristone
    • Monoamine Oxidase Inhibitors
    • Nefazodone
    • Nelfinavir
    • Nirmatrelvir-ritonavir
    • Ombitasvir-paritaprevir-ritonavir
    • Ombitasvir-paritaprevir-ritonavir plus dasabuvir
    • Ondansetron
    • Opioid Agonists
    • Pentamidine (Systemic)
    • Pimozide
    • Posaconazole
    • Posaconazole
    • QT-prolonging Agents
    • Ritonavir and ritonavir-containing coformulations
    • Saquinavir
    • Sertindole
    • Sirolimus
    • Telithromycin
    • Tucatinib
    • Voriconazole


    Tell your doctor if you have a history of liver disease or are currently taking medication that affects your heart rhythm. Motilium can cause changes in heart rhythm and potentially serious side effects.

    Motilium is not recommended for pregnant or breastfeeding women without consulting a healthcare professional.

    Motilium can cause increases in prolactin levels, which can cause low libido, headaches, breast discharge, and breast growth in males.

    Side Effects

    The most common adverse reactions may include:

    • Abdominal cramps
    • Acid regurgitation
    • Asthenia
    • Change in appetite
    • Constipation
    • Diarrhea
    • Dizziness
    • Galactorrhea not associated with childbirth
    • Gynecomastia
    • Headache
    • Heartburn
    • Hot flash
    • Increased serum cholesterol
    • Increased serum prolactin
    • Increased thirst
    • Insomnia
    • Irritability
    • Lethargy
    • Migraine
    • Nausea
    • Nervousness
    • Stomatitis
    • Xerostomia


    1. Motilium [package insert]. Auckland, NZ: Johnson and Johnson; 2022.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 10539

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