Description
Prolonged-release tablet. Mirabegron is indictaed for the symptomatic treatment of urgency, increased micturition frequency and/or urgency incontinence as may occur in adult patients with overactive bladder (OAB) syndrome.
| Fact Table |
| Formula |
C21H24N4O2S |
| License |
US FDA, EU EMA |
| Bioavailability |
29–35% |
| Legal status |
Rx-Only |
| Chemical Name |
Mirabegron |
| Elimination half-life |
50 hours |
| Dosage (Strength) |
25mg, 50mg |
| Pregnancy |
Not recommended |
| Brands |
Myrbetriq |
| Protein binding |
71% |
| PubChem CID |
9865528 |
| MedlinePlus |
a612038 |
| ChEBI |
65349 |
| ATC code |
G04BD12 |
| DrugBank |
DB08893 |
| KEGG |
D09535 |
| Routes of administration |
By mouth (tablets) |
Directions
The recommended dose is 50 mg once daily with or without food.The tablet is to be taken once daily, with liquids, swallowed whole and is not to be chewed, divided, or crushed.
The safety and efficacy of mirabegron in children below 18 years of age have not yet been established.
Ingredients
ACTIVE: Mirabegron
INACTIVE: polyethylene oxide, polyethylene glycol, hydroxypropyl cellulose, butylated hydroxytoluene, magnesium stearate, hypromellose, yellow ferric oxide and red ferric oxide (25 mg only)
Cautions
Mirabegron has not been studied in patients with end stage renal disease (GFR < 15 mL/min/1.73 m2 or patients requiring haemodialysis) and, therefore, it is not recommended for use in patient population with renal impairment. Data are limited in patients with severe renal impairment (GFR 15 to 29 mL/min/1.73 m2),a dose reduction to 25 mg is recommended in this population.
Mirabegron has not been studied in patients with severe hepatic impairment (Child-Pugh Class C) and, therefore, it is not recommended for use in this patient population.
Side Effects
COMMON: Urinary tract infection, Tachycardia, Nausea.
UNCOMMON:Vaginal infection, Cystitis, Palpitation, Dyspepsia, Gastritis, Urticaria, Rash, Pruritus, Joint swelling, Vulvovaginal pruritus,Blood pressure increased. RARE: Eyelid oedema, Lip oedema, Leukocytoclastic vasculitis, Purpura, Angioedema.
Frequently Asked Questions about Myrbetriq
What is Myrbetriq used for?
Myrbetriq is used to treat overactive bladder (OAB) symptoms, including frequent urination, urgency, and incontinence. It helps relax bladder muscles. It can also be used for neurogenic detrusor overactivity (NDO) in children with nerve damage.
Why is Myrbetriq so expensive?
Several factors contribute to its high cost, including patent laws, which prohibit the sale of a generic alternative, and unregulated pricing.
What is the side effect of Myrbetriq?
Myrbetriq can cause a range of side effects. Some common ones include headache, increased blood pressure, constipation, dizziness, diarrhea, and back pain. It's essential to consult your healthcare provider if you experience any unusual symptoms while taking this medication.
Is there a cheaper alternative to Myrbetriq?
Cheaper alternatives to Myrbetriq include Gemtesa, Oxybutynin, Tolterodine, and Botox injections into the bladder muscle.
Is it better to take Myrbetriq at night or in the morning?
Take Myrbetriq once daily at a consistent time that suits your routine and ensures you won't forget.
Can myrbetriq cause weight gain?
No, Myrbetriq doesn't cause weight gain as a side effect. Studies have not reported weight gain in people who took Myrbetriq. However, if you experience difficulty emptying your bladder (urinary retention), your weight may appear higher due to fluid retention.
Can I stop taking Myrbetriq?
Before discontinuing mirabegron, consult your doctor. If you abruptly stop taking this medication, it will take approximately 10 days for it to be completely eliminated from your body. During this time, there's a risk that your symptoms of an overactive bladder may reappear or worsen .
Does Myrbetriq affect sleep?
Myrbetriq does not typically affect sleep as a common side effect. However, some people may experience unusual tiredness or weakness while taking it. If you have concerns about your sleep patterns, consult your doctor for personalized advice.
Is Myrbetriq for long term use?
Yes, Myrbetriq is suitable for long-term use. However, always follow your doctor's guidance and monitor any potential side effects or changes in your condition during extended usage.
What should you not take with Myrbetriq?
Ketoconazole, Rifampin, Solifenacin succinate, Tamsulosin, Metformin, and Oral contraceptives should be avoided while taking Myrbetriq.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13162
Prescription Required
