What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Mytesi (Crofelemer)


Mytesi (Crofelemer)

Prescription Required


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  • Product Details


    Your doctor may prescribe Mytesi to treat non-infectious diarrhea in adult patients who have Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS) from HIV. The patient must be on antiretroviral therapy. 

    Mytesi works by inhibiting a protein in the intestines called cyclic adenosine monophosphate (cAMP)-stimulated cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. It also blocks calcium-activated chloride ion channels in the enterocyte luminal membrane.

    People with HIV/AIDS infection are at high risk for side effects like diarrhea when taking antiretrovirals. These types of medications are used to control HIV/AIDS infection.

    Fact Table




    US FDA


    Little or no absorption from the gut

    Legal status

    AU, US: Rx Only

    Chemical Name


    Elimination half-life

    Not Determined

    Dosage (Strength)



    No Known Risks



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth


    Take Mytesi 125 mg twice daily with or without food. The capsules have a coating and should not be crushed or chewed as it may affect the absorption of the drug. 


    The active ingredient in Mytesi is crofelemer. Do not crush or chew this capsule before taking it.


    There are no known significant drug-drug interactions with this Mystesi.

    Mytesi capsules are stored at room temperature.


    Before starting Myesi, your doctor or healthcare professional should confirm that your diarrhea is not from a bacterial, viral, or fungal infection.

    Tell your doctor if you have a history of liver problems while taking this drug. 

    Side Effects

    The most common adverse effects of Myesi can include the following:

    • Abdominal distension
    • Abdominal pain
    • Acne vulgaris
    • Anxiety
    • Constipation
    • Cough
    • Decreased white blood cell count
    • Depression
    • Dermatitis
    • Dizziness
    • Dyspepsia
    • Flatulence
    • Gastroenteritis
    • Giardiasis
    • Hemorrhoids
    • Herpes zoster
    • Increased liver enzymes
    • Nausea
    • Nephrolithiasis
    • Pollakiuria
    • Sinusitis
    • Urinary tract infection
    • Xerostomia

    Tell your doctor and pharmacist if you have any of the above reactions while taking this drug. Most side effects are temporary and will go away after stopping the drug for some time.


    Mytesi, San Francisco, CA: Napo Pharmaceuticals; 2018.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13584

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