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Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Neoral Oral Solution (Cyclosporine)
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Product Details
Description
Neoral oral solution is prescribed to prevent graft rejection in patients who have received liver, skin, kidney, heart, pancreas, small intestine, lung, or bone marrow transplant. Neoral should only be prescribed by healthcare providers experienced in transplant medicine.
Neoral is a potent immunosuppressant that lowers a patient’s immune system activity to not attack the transplanted organ.
Fact Table
Formula
C62H111N11O12
License
US FDA, EU EMA
Bioavailability
variable
Legal status
Rx-only
Chemical Name
Cyclosporine
Elimination half-life
variable (about 24 hours)
Dosage (Strength)
100mg/ml
Pregnancy
No Known Risk
Brands
Neoral
Protein binding
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PubChem CID
5284373
MedlinePlus
a682116
ChEBI
8435
ATC code
a601207
DrugBank
DB00091
KEGG
D00184
Routes of administration
Oral
Directions
Take Neoral exactly as prescribed by your doctor. The dose may be changed based on your blood levels of cyclosporine.
Never change the pharmacy you purchase without first discussing it with your transplant team.
Never change your formulation of cyclosporine without discussing it with your transplant team.
Ingredients
The active ingredient in Neoral is cyclosporine.
Cautions
Neoral can increase the risk of serious infection.
Tell your doctor if you have a history of kidney or liver problems.
Ask your doctor for a full list of side effects that applies to you.
Interactions
Neoral has many possible drug-drug interactions. Tell your transplant team about all drugs you are taking, including over-the-counter, herbals, and supplements.
Common drug-drug interactions with Neoral include:
- Allopurinol
- Amiodarone
- Amphotericin B
- Azithromycin
- Bosentan
- Bromocriptine
- Carbamazepine
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Colchicine
- Diclofenac
- Diltiazem
- Erythromycin
- Fenofibrate
- Fluconazole
- Gemfibrozil
- Gentamicin
- Itraconazole
- Ketoconazole
- Ketoconazole
- Melphalan
- Methotrexate
- Methylprednisolone
- Metoclopramide
- Naproxen
- Nefazodone
- Nicardipine
- Octreotide
- Oral contraceptives
- Orlistat
- Oxcarbazepine
- Phenobarbital
- Phenytoin
- Ranitidine
- Rifampin
- St. John's Wort
- Sulindac
- Tacrolimus
- Terbinafine
- Tobramycin
- Trimethoprim-Sulfamethoxazole
- Vancomycin
- Verapamil
- Voriconazole
Drug-drug interactions may decrease the levels of Neoral in the body and lead to transplant rejection.
Side Effects
Common side effects of Neoral include:
- Abdominal distress
- Diarrhea
- Dyspepsia
- Edema
- Female genital tract disease
- Gingival hyperplasia
- Headache
- Hirsutism
- Hypertension
- Increased serum creatinine
- Increased serum triglycerides
- Increased susceptibility to infection
- Leg cramps
- Nausea
- Paresthesia
- Renal insufficiency
- Tremor
- Upper respiratory tract infection
- Urinary tract infection
- Viral infection
References
Neoral Oral Solution [package insert]. East Hanover, NJ: Novartis; 2009.
Frequently Asked Questions about Neoral (Cyclosporine)
What is Neoral (Cyclosporine)?
Neoral is a brand name for the medication Cyclosporine. It is an immunosuppressive drug used to prevent organ rejection in transplant recipients and to treat certain autoimmune conditions.
How does Cyclosporine work?
Cyclosporine works by suppressing the immune system's response, preventing it from attacking transplanted organs or causing damage in autoimmune diseases.
What conditions are treated with Neoral?
Neoral is used to treat conditions such as organ transplant rejection, rheumatoid arthritis, psoriasis, and certain types of inflammatory bowel disease.
How is Neoral administered?
Neoral is available in both oral capsule and oral solution forms. The specific dosing and administration instructions will be provided by your healthcare provider based on your condition.
What are the common side effects of Neoral?
Common side effects of Neoral may include high blood pressure, kidney problems, tremors, headache, nausea, and increased hair growth. It's essential to discuss potential side effects with your healthcare provider.
Can Neoral interact with other medications?
Yes, Neoral can interact with various medications, including some antibiotics and antifungal drugs. It's essential to inform your healthcare provider about all the medications you are taking to avoid potential interactions.
How long do I need to take Neoral?
The duration of Neoral treatment varies depending on the condition being treated. For transplant recipients, it may be lifelong, while for autoimmune conditions, your doctor will determine the appropriate treatment duration.
Can I drink alcohol while taking Neoral?
It is generally recommended to limit or avoid alcohol while taking Neoral, as alcohol can interact with the medication and may exacerbate some of its side effects.
Can I become pregnant while on Neoral?
Neoral can be harmful to a developing fetus. If you are of childbearing age and sexually active, it's crucial to use effective contraception while taking Neoral and discuss family planning with your healthcare provider.
How often should I have blood tests while on Neoral?
Regular blood tests are essential to monitor the levels of Cyclosporine in your body, as well as to check for any potential side effects. The frequency of these tests will be determined by your healthcare provider.
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IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 9367
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