What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Nexlizet (Bempedoic acid and Ezetimibe)
Prescription Required
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Product Details
Description
Nexlizet (bempedoic acid and ezetimibe) is used with diet and a statin medication to treat adults with heterozygous familial hypercholesterolemia or atherosclerotic cardiovascular disease who need additional lowering of low-density lipoprotein cholesterol (LDL-C).
Fact Table
Formula
C19H36O5
License
US DailyMed, EU EMA
Bioavailability
-
Legal status
Rx-Only
Chemical Name
Bempedoic acid
Elimination half-life
21±11 hrs
Dosage (Strength)
180mg/10mg
Pregnancy
Contraindicated
Brands
Nexlizet
Protein binding
99.3%
PubChem CID
10472693
MedlinePlus
a620020
ChEBI
149601
ATC code
C10AX15
DrugBank
DB11936
KEGG
D10691
Routes of administration
By mouth
Directions
Nexlizet is available in a tablet that contains 180 mg of bempedoic acid and 10 mg of ezetimibe.
The dose is to take one tablet by mouth once daily. It can be taken with or without food.
The tablet should not be crushed or chewed. It should be swallowed whole.
If you are taking bile acid sequestrants, take Nexlizet at least 2 hours before or 4 hours after taking bile acid sequestrants.
Ingredients
The active ingredients in Nexlizet are bempedoic acid and ezetimibe.
Contraindications
Do not take Nexlizet if you are allergic to ezetimibe or any of the other ingredients in Nexlizet.
Cautions
- Before you start treatment with Nexlizet, inform your doctor:
- Of any medications you take. These include prescription and over-the-counter medications, vitamins, and herbal supplements. Avoid taking Nexlizet with simvastatin more than 20 mg or pravastatin more than 40 mg.
- Of your allergies.
- Of your medical conditions.
- If you are pregnant or plan to become pregnant.
- If you are breastfeeding or plan to breastfeed.
- Nexlizet can cause an increase in uric acid levels in the blood which can lead to gout.
- Nexlizet can cause tendon rupture. Call your doctor right away if you experience pain, swelling, or inflammation of your joints.
Side Effects
Nexlizet can cause side effects such as upper respiratory tract infection, the flu, bronchitis, stomach pain, back pain, joint pain, extremity pain, anemia, increased liver enzymes, diarrhea, tiredness, sinusitis, muscle spasms, and increased uric acid levels in the blood.
Tell your doctor right away if you experience negative side effects or your side effects won't go away.
Reference:
Nexlizet. Ann Arbor, MI: Esperion Therapeutics, Inc.; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13645
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